Can tissue transglutaminase be a marker of idiopathic inflammatory myopathies?

Gendek, Ewa G.; Kędziora, J; Gendek-Kubiak, Hanna

doi:10.1016/j.imlet.2004.11.017

Cited by 7 publications

(9 citation statements)

References 19 publications

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“…However, during muscle development, there is a transient expression of this protein (7). All these data suggest that TG2 over-expression is a common feature of generalized IIM (2). In DM and in PM, a TG2 over-expression has been detected by immunocytochemistry in the endomysial connective tissue and in sarcolemma, sometimes decorating degenerative muscle fibers; data of TG 2 overexpression in IIM has also been confirmed by semiquantitative real-time RT-PCR technique (8).…”

Section: Introductionmentioning

confidence: 65%

“…More recently, an increased TG2 immunostaining has been evidenced also in capillary endothelia of guinea pig quadriceps muscles injected with serum of patients with DM (2). All these data suggest that TG2 over-expression is a common feature of generalized IIM (2).…”

Section: Introductionmentioning

confidence: 74%

“…More recently, Gendek et al reported an intense TG2 immunostaining in endomuscular vessels of guinea pig quadriceps injected with DM patients serum, suggesting that this phenomenon may be a sign of a local protective reaction against the inflammation spreading since cross-linking of extracellular matrix proteins (2). To date, if TG2 expression in skeletal muscle fibres may represent a proinflammatory event or an attempt to create extracellular barriers to limit the immunopathological process is still debated.…”

Section: Discussionmentioning

confidence: 99%

“…However, the complement involvement in PM has not been excluded (2). In s-IBM muscle, cytotoxic CD8 + T cells and macrophages focally surround and invade non-necrotic muscle fibres: biopsy tissues reveal abnormal muscle fibers showing rimmed vacuoles, endomysial inflammation, intracellular amyloid deposition and abundant tubulofilaments within the vacuolated muscle fibers (3).…”

Section: Introductionmentioning

confidence: 99%

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Expression of transglutaminase 2 does not differentiate focal myositis from generalized inflammatory myopathies

Macaione¹,

Aguennouz

Mazzeo

et al. 2007

Acta Neurologica Scandinavica

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show abstract

Section: Introductionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Expression of transglutaminase 2 does not differentiate focal myositis from generalized inflammatory myopathies

Macaione¹,

Aguennouz

Mazzeo

et al. 2007

Acta Neurologica Scandinavica

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show abstract

“…An elevated expression of TG2 has been found in muscle tissue from patients with myositis compared to normal muscle, and TG2 is suggested to be a marker of idiopathic inflammatory myopathies (56)(57)(58). There have been reports of an increased frequency of gluten-sensitivity among patients with myositis but screening for autoantibodies against TG2 in serum has so far been negative and needs to be further investigated.…”

Section: Glutenmentioning

confidence: 99%

Nutrition and Polymyositis and Dermatomyositis

Loell¹,

Lundberg²

2008

Nutrition and Rheumatic Disease

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Chronic muscle inflammation in polymyositis or dermatomyositis causes muscle weakness and fatigue.• The chronic inflammation could lead to a catabolic state and additional loss of muscle mass.• The chronic muscle inflammation could induce a metabolic myopathy.• Body weight may not be reliable to measure muscle loss, rather measurement of body composition is recommended. • For patients with polymyositis or dermatomyositis it is important to provide the body with the right amount of macronutrients and trace elements for maintenance and improvement of body functions. • One recommendation is supplementation with calcium and vitamin D.• Another recommendation is regular physical exercise that during limited periods can be combined with supplements such as creatine, if done under the care of a physician.

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Celiac disease and antibodies associated with celiac disease in patients with inflammatory myopathy

Selva-O’Callaghan

Casellas²,

Torres

et al. 2006

Muscle and Nerve

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Celiac disease is usually associated with autoimmune disorders and has occasionally been reported in patients with inflammatory myopathies. Our aim was to determine the presence of celiac disease and antibodies associated with celiac disease in patients with inflammatory myopathies and to investigate their relationship. Serum antigliadin, anti–tissue transglutaminase, and antiendomysial antibodies were determined in 51 patients with inflammatory myopathies. HLA‐DQ2 and ‐DQ8 alleles were studied to assess their complementary diagnostic value. Jejunal biopsy was performed in patients with moderate to high levels of antigliadin antibodies. Patients with jejunal histology consistent with celiac disease initiated a gluten‐free diet. Seventeen patients (31%) were positive for antigliadin antibodies, which were significantly more frequent in patients with inclusion‐body myositis than dermatomyositis (P < 0.001). Positive status to HLA‐DQ2 and/or ‐DQ8 did not differ between antigliadin‐positive (75% and 12.5%) or ‐negative (60% and 15%) patients. Three of five jejunal biopsies were diagnostic for celiac disease with histological normalization after a gluten‐free diet. Thus, celiac disease is more prevalent in patients with inflammatory myopathies than in the general population. Positive status to HLA‐DQ2 allele, which is known to be more frequent in patients with inflammatory myopathies, could explain the high prevalence of antigliadin antibodies in this population. The diagnostic value of HLA‐DQ2 or ‐DQ8 haplotypes to detect celiac disease in patients with inflammatory myopathy is limited. Muscle Nerve, 2006

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Can tissue transglutaminase be a marker of idiopathic inflammatory myopathies?

Cited by 7 publications

References 19 publications

Expression of transglutaminase 2 does not differentiate focal myositis from generalized inflammatory myopathies

Expression of transglutaminase 2 does not differentiate focal myositis from generalized inflammatory myopathies

Nutrition and Polymyositis and Dermatomyositis

Celiac disease and antibodies associated with celiac disease in patients with inflammatory myopathy

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