Can the Use of the Radial Artery Be Expanded to All Patients with Different Surgical Grafting Techniques? Early Clinical and Angiographic Results in 600 Patients

Al‐Ruzzeh, Sharif; Modine, Thomas; Athanasiou, Thanos; Mazrani, Waseem; Azeem, Fazil; Nakamura, Koki; Bustami, Mahmoud; Ilsley, Charles; Amrani, Mohamed

doi:10.1111/j.0886-0440.2005.05003.x

Cited by 17 publications

(9 citation statements)

References 26 publications

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“…To minimise or eliminate bias from differences in learning curves, surgeons, centres, and conduits, we gained experience, before starting the trial, from non-selective use of the off-pump technique in more than 500 unselected patients,2 using different types of arterial and venous grafts 31 32…”

Section: Discussionmentioning

confidence: 99%

Effect of off-pump coronary artery bypass surgery on clinical, angiographic, neurocognitive, and quality of life outcomes: randomised controlled trial

Al‐Ruzzeh

George

Bustami

et al. 2006

BMJ

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165

110

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Objective To compare the clinical, angiographic, neurocognitive, and quality of life outcomes of off-pump coronary artery bypass surgery with conventional coronary artery bypass grafting surgery using cardiopulmonary bypass. Design Randomised controlled clinical trial. Setting Tertiary cardiothoracic centre in Middlesex, England. Participants 168 patients (27 women) requiring primary isolated coronary artery bypass grafting surgery. Interventions Patients were randomised to conventional coronary artery bypass grafting surgery using cardiopulmonary bypass (n = 84) or off-pump coronary artery bypass surgery (n = 84), carried out by one surgeon. Angiographic examination was carried out at three months postoperatively. Neurocognitive tests were carried out at baseline and at six weeks and six months postoperatively. Main outcome measures Clinical outcome, graft patency at three months, neurocognitive function at six weeks and six months, and health related quality of life. Results Graft patency was evaluated by angiography in 151 (89.9%) patients and was similar between the cardiopulmonary bypass and off-pump groups (risk difference − 1%, 95% confidence interval − 5% to 4%), with the off-pump group considered the treatment group. Patients in the off-pump group required fewer blood transfusions (1.7 units v 1.0 unit, P = 0.02), shorter duration of mechanical ventilation (7.7 hours v 3.9 hours, P = 0.03), and shorter hospital stay (10.8 days v 8.9 days). Scores for neurocognitive function showed a significant difference in three memory subtests at six weeks and two memory subtests at six months in favour of the off-pump group. Conclusions Patients who underwent off-pump coronary artery bypass surgery showed similar patency of grafts, better clinical outcome, shorter hospital stay, and better neurocognitive function than patients who underwent conventional coronary artery bypass grafting surgery using cardiopulmonary bypass.

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Section: Discussionmentioning

confidence: 99%

Effect of off-pump coronary artery bypass surgery on clinical, angiographic, neurocognitive, and quality of life outcomes: randomised controlled trial

Al‐Ruzzeh

George

Bustami

et al. 2006

BMJ

Self Cite

165

110

View full text Add to dashboard Cite

show abstract

“…Similar results were shown in retrospective assessment of 600 patients, where 93 (15.5%) were restudied, with 92.5% of RA grafts patency rate, and all occluded grafts were related to the coronary arteries with less severe obstructions, 56. 3% + 15.4 (P <0.001) [28].…”

Section: Resultsmentioning

confidence: 94%

Revascularização miocárdica com artéria radial: influência da anastomose proximal na oclusão a médio e longo prazo

Carneiro¹,

Platania²,

Dallan³

et al. 2009

Rev Bras Cir Cardiovasc

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Revascularização miocárdica com artéria radial: influência da anastomose proximal na oclusão a médio e longo prazo Coronary artery bypass grafting using the radial artery: influence of proximal anastomosis site in mid-term and long-term graft patency Abstract Objective: To determine whether the proximal anastomosis interferes or not in mid-and long-term patency of these grafts.Methods: One hundred twenty-three out of 481 patients who had undergone surgery using radial artery (RA) were restudied. The mean age was 58. 39CARNEIRO, LJ ET AL -Coronary artery bypass grafting using the radial artery: influence of proximal anastomosis site in mid-term and long-term graft patency Bras Cir Cardiovasc 2009; 24(1): 38-43 Rev

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“…Previous studies demonstrated that patency rates of bypass grafts might be lower when the bypass conduit was used as an aorto-coronary fashion than when it was used as a composite graft based on the LITA 78. Contradictory results also existed that the patency of the radial artery (RA) was lower when it was used as a composite graft based on the LITA compared to aorto-coronary grafts 2324. However, a previous systematic review demonstrated that the best evidence suggests that the site of proximal anastomosis has little or no effect on RA graft patency following CABG 25…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Plasma Metabolome Profiles Between the Internal Thoracic Artery and Ascending Aorta in Patients Undergoing Coronary Artery Bypass Graft Surgery Using Gas Chromatography Time-of-Flight Mass Spectrometry

Kim

Jang

et al. 2019

J Korean Med Sci

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Background The left internal thoracic artery (LITA) has been used as the first conduit of choice in coronary artery bypass grafting (CABG) because of excellent long-term patency and outcomes. However, no studies have examined substances other than nitric oxide that could be beneficial for the bypass conduit, native coronary artery or ischemic myocardium. This study was conducted to evaluate differences in metabolic profiles between the LITA and ascending aorta using gas chromatography-time of flight-mass spectrometry (GC-TOF-MS). Methods Twenty patients who underwent CABG using the LITA were prospectively enrolled. Plasma samples were collected simultaneously from the LITA and ascending aorta. GC-TOF-MS based untargeted metabolomic analyses were performed and a 2-step volcano plot analysis was used to identify distinguishable markers from two plasma metabolome profiles. Semi-quantitative and quantitative analyses were performed using GC-TOF-MS and enzyme-linked immunosorbent assay, respectively, after selecting target metabolites based on the metabolite set enrichment analysis. Results Initial volcano plot analysis demonstrated 5 possible markers among 851 peaks detected. The final analysis demonstrated that the L-cysteine peak was significantly higher in the LITA than in the ascending aorta (fold change = 1.86). The concentrations of intermediate metabolites such as L-cysteine, L-methionine and L-cystine in the ‘cysteine and methionine metabolism pathway' were significantly higher in the LITA than in the ascending aorta (2.0-, 1.4- and 1.2-fold, respectively). Quantitative analysis showed that the concentration of hydrogen sulfide (H 2 S) was significantly higher in the LITA. Conclusion The plasma metabolome profiles of the LITA and ascending aorta were different, particularly higher plasma concentrations of L-cysteine and H 2 S in the LITA.

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Can the Use of the Radial Artery Be Expanded to All Patients with Different Surgical Grafting Techniques? Early Clinical and Angiographic Results in 600 Patients

Abstract: The use of the RA can be expanded to all patients with different surgical grafting techniques and provides satisfactory clinical and angiographic outcomes.

Cited by 17 publications

References 26 publications

Effect of off-pump coronary artery bypass surgery on clinical, angiographic, neurocognitive, and quality of life outcomes: randomised controlled trial

Effect of off-pump coronary artery bypass surgery on clinical, angiographic, neurocognitive, and quality of life outcomes: randomised controlled trial

Revascularização miocárdica com artéria radial: influência da anastomose proximal na oclusão a médio e longo prazo

Comparison of the Plasma Metabolome Profiles Between the Internal Thoracic Artery and Ascending Aorta in Patients Undergoing Coronary Artery Bypass Graft Surgery Using Gas Chromatography Time-of-Flight Mass Spectrometry

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