Can the Use of Antibiotics Alter the Susceptibility to Allergic Diseases?

Lee, So Yeon

doi:10.4168/aair.2018.10.5.425

Cited by 3 publications

(4 citation statements)

References 16 publications

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“…As part of this concept, there is growing evidence that the increased prevalence of allergic diseases can be attributed to increased exposure to antibiotics. (4) In particular, the antibiotic prescription rate for all pediatric patients increased from 34.8% in 2010 to 70.4% in 2014 in Korea. (5) Therefore, it is necessary to investigate the relationship between increasing exposure to antibiotics and the development of AD.…”

Section: Months(3)mentioning

confidence: 99%

Effect of early-life antibiotic exposure and IL-13 polymorphism on atopic dermatitis phenotype

Park

Lee

et al. 2021

Preprint

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Background: Although atopic dermatitis (AD) is associated with certain gene variants, the rapidly increasing incidence of AD suggests that environmental factors contribute to disease development. In this study, we investigated the association of AD incidence and phenotype with antibiotic exposure within 6 months of age, considering the dose administered and genetic risk. Methods: This study included 1,637 children from the COCOA birth cohort. Pediatric allergists assessed the presence of AD at each visit and obtained information about antibiotic exposure for more than 3 days. IL-13 (rs20541) polymorphism was genotyped by the TaqMan method. We stratified the AD phenotypes into 4 groups and used multinomial logistic regression models for analysis. Results: Antibiotic exposure within 6 months of age was found to increase the risk of AD within 3 years of life (aOR=1.40, 95%, CI 1.09–1.81) in dose-dependent manner. Antibiotic exposure more than twice increased the risk of the early-persistent AD phenotype (aOR=2.50, 95% CI 1.35–4.63). There was a weak interaction between genetic polymorphisms and environmental factors on the development of AD (p for interaction=0.06). Children with the IL-13 (rs20541) GA+ AA genotype have a higher risk of the early-persistent AD phenotype when exposed to antibiotics more than twice than those with the IL-13 (rs20541) GG genotype and without exposure to antibiotics (aOR=4.73, 2.01–11.14). Conclusion: Antibiotic exposure within 6 months was related to the incidence of early-persistent AD and a dose-dependent increase in the incidence of AD in childhood, whose effect was modified by the IL-13 (rs20541) genotype.

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Section: Months(3)mentioning

confidence: 99%

Effect of early-life antibiotic exposure and IL-13 polymorphism on atopic dermatitis phenotype

Park

Lee

et al. 2021

Preprint

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“…Antibiotic exposure during maternal pregnancy or early life 67 68 69 70 71 and cesarean delivery 57 72 73 can increase the prevalence of asthma in children by affecting the gut microbiota and other mechanisms. Anti-parasitic therapy is also shown to be associated with increased prevalence of asthma.…”

Section: Environmental and Microbial Exposurementioning

confidence: 99%

Important Role of Immunological Responses to Environmental Exposure in the Development of Allergic Asthma

Lin

Ren

Xiao

et al. 2020

Allergy Asthma Immunol Res

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Allergic asthma is a public health problem that affects human health and socioeconomic development. Studies have found that the prevalence of asthma has significantly increased in recent years, which has become particularly pronounced in developed countries. With rapid urbanization in China in the last 3 decades, the prevalence of asthma has increased significantly in urban areas. As changes in genetic backgrounds of human populations are limited, environmental exposure may be a major factor that is responsible for the increased prevalence of asthma. This review focuses on environmental components of farms and rural areas that may have protective effects in reducing the development of asthma. Farm and rural related microorganism- and pathogen-associated molecular patterns are considered to be important environmental factors that modulate host's innate and adaptive immune system to induce protection effects later in life. Environmental microbial-related immunotherapy will also be discussed as the future research direction for the prevention of allergic asthma.

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“…As part of this concept, there is growing evidence that the increased prevalence of allergic diseases can be attributed to increased exposure to antibiotics. 3 Previous studies have demonstrated that the composition and function of the gut microbiome at 6 months of age could affect the course of AD in early childhood 4 and antibiotic administration aggravates clinical signs in a mouse model of AD. 5 No other studies have analyzed the severity and natural course of AD according to the frequency of early-life antibiotic exposure.…”

Section: Introductionmentioning

confidence: 99%

“…This hypothesis states that the Western lifestyle not only limits infection and microbial exposure but also alters the colonization of the gut microbiome, thereby disrupting the development of the immune system and leading to allergic disease. As part of this concept, there is growing evidence that the increased prevalence of allergic diseases can be attributed to increased exposure to antibiotics 3 . Previous studies have demonstrated that the composition and function of the gut microbiome at 6 months of age could affect the course of AD in early childhood 4 and antibiotic administration aggravates clinical signs in a mouse model of AD 5 .…”

Section: Introductionmentioning

confidence: 99%

Effect of early‐life antibiotic exposure and IL‐13 polymorphism on atopic dermatitis phenotype

Park

Lee

et al. 2021

Pediatric Allergy Immunology

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Can the Use of Antibiotics Alter the Susceptibility to Allergic Diseases?

Cited by 3 publications

References 16 publications

Effect of early-life antibiotic exposure and IL-13 polymorphism on atopic dermatitis phenotype

Effect of early-life antibiotic exposure and IL-13 polymorphism on atopic dermatitis phenotype

Important Role of Immunological Responses to Environmental Exposure in the Development of Allergic Asthma

Effect of early‐life antibiotic exposure and IL‐13 polymorphism on atopic dermatitis phenotype

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