Can the upper inner side of the thigh become a new option for insulin injection?

Yuan, Jingyun; Chen, Yan; Xuan, Yanting; Cao, Lihong; Zhu, Jing; Wang, Fenrong; Zhou, Xiaona; Ye, Qing; Liao, Liping; Zheng, Yun; Zhou, Qun; Chen, Xiaohui; Chen, Min; Zhou, Weibin

doi:10.1185/03007995.2016.1174107

Cited by 6 publications

(7 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This effect is probably to a large extent determined by differences in SBF between the injection sites, but differences in insulin degradation might also be a factor of importance [ 9 , 114 ]. Commonly used regions for SC injection include the upper arm/deltoid, abdomen, outer thighs, and buttocks [ 13 ]. As insulin is absorbed fastest from the abdomen, slower from the arm followed by thighs and buttocks, choice of injection region may for many insulin preparations influence the metabolic response to insulin [ 67 , 111 , 115 , 118 , 122 – 125 , 130 , 131 ].…”

Section: Physiological Factors and Factors Related To The Injectiomentioning

confidence: 99%

Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on Variability

Gradel

Porsgaard

Lykkesfeldt

et al. 2018

Journal of Diabetes Research

130

100

View full text Add to dashboard Cite

Variability in the effect of subcutaneously administered insulin represents a major challenge in insulin therapy where precise dosing is required in order to achieve targeted glucose levels. Since this variability is largely influenced by the absorption of insulin, a deeper understanding of the factors affecting the absorption of insulin from the subcutaneous tissue is necessary in order to improve glycaemic control and the long-term prognosis in people with diabetes. These factors can be related to either the insulin preparation, the injection site/patient, or the injection technique. This review highlights the factors affecting insulin absorption with special attention on the physiological factors at the injection site. In addition, it also provides a detailed description of the insulin absorption process and the various modifications to this process that have been utilized by the different insulin preparations available.

show abstract

Section: Physiological Factors and Factors Related To The Injectiomentioning

confidence: 99%

Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on Variability

Gradel

Porsgaard

Lykkesfeldt

et al. 2018

Journal of Diabetes Research

130

100

View full text Add to dashboard Cite

show abstract

“…Glargine insulin should not be mixed with any other insulin due to unique low pH of its diluents (A2). [438182]…”

Section: Preinjection Readinessmentioning

confidence: 99%

“…[82] Use same site at the same time each day and rotate injection site to avoid glucose variability and LH (same time same site rule).…”

Section: Injection Site and Techniquementioning

confidence: 99%

Forum for injection technique and therapy expert recommendations, India: The Indian recommendations for best practice in insulin injection technique, 2017

Tandon

Kalra

Balhara

et al. 2017

Indian J Endocr Metab

View full text Add to dashboard Cite

Health-care professionals in India frequently manage injection or infusion therapies in persons with diabetes (PWD). Patients taking insulin should know the importance of proper needle size, correct injection process, complication avoidance, and all other aspects of injection technique from the first visit onward. To assist health-care practitioners in their clinical practice, Forum for Injection Technique and Therapy Expert Recommendations, India, has updated the practical advice and made it more comprehensive evidence-based best practice information. Adherence to these updated recommendations, learning, and translating them into clinical practice should lead to effective therapies, improved outcomes, and lower costs for PWD.

show abstract

“…For instance, automatic injection of epinephrine is used to quickly treat severe allergic reactions 1 . Insulin is administered both by syringe and by insulin pump at a low dose rate to spread the drug over a long period of time 2 – 5 . The slow injection rate resembles the situation at which insulin is gradually released from the pancreas.…”

Section: Introductionmentioning

confidence: 99%

“…Although drug injections have been administered in a similar manner for a long time, the guideline for drug injection has been continuously updated based on clinical trials for better treatment with overcoming technical limitations 1 , 2 , 6 – 9 . The most dominant limitation is considerable variation in the absorption and action of drug from patient to patient, but more importantly from injection to injection for the same patient 10 – 13 .…”

Section: Introductionmentioning

confidence: 99%

Effective method for drug injection into subcutaneous tissue

Kim

Park

Lee

2017

Sci Rep

View full text Add to dashboard Cite

Subcutaneous injection of drug solution is widely used for continuous and low dose drug treatment. Although the drug injections have been administered for a long time, challenges in the design of injection devices are still needed to minimize the variability, pain, or skin disorder by repeated drug injections. To avoid these adverse effects, systematic study on the effects of injection conditions should be conducted to improve the predictability of drug effect. Here, the effects of injection conditions on the drug permeation in tissues were investigated using X-ray imaging technique which provides real-time images of drug permeation with high spatial resolution. The shape and concentration distribution of the injected drug solution in the porcine subcutaneous and muscle tissues are visualized. Dynamic movements of the wetting front (WF) and temporal variations of water contents in the two tissues are quantitatively analyzed. Based on the quantitative analysis of the experimental data, the permeability of drug solution through the tissues are estimated according to permeation direction, injection speed, and tissue. The present results would be helpful for improving the performance of drug injection devices and for predicting the drug efficacy in tissues using biomedical simulation.

show abstract

Can the upper inner side of the thigh become a new option for insulin injection?

Abstract: The upper inner thigh might be a new option for insulin injection rotation.

Cited by 6 publications

References 16 publications

Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on Variability

Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on Variability

Forum for injection technique and therapy expert recommendations, India: The Indian recommendations for best practice in insulin injection technique, 2017

Effective method for drug injection into subcutaneous tissue

Contact Info

Product

Resources

About