Can the Number of Radiofrequency Activations Predict Serious Adverse Events after Bronchial Thermoplasty? A Retrospective Case-Control Study

Yamamoto, Seigo; Iikura, Motoyasu; Kakuwa, Tamaki; Tsujimoto, Yoshie; Matsubayashi, Sachi; Nagano, Naoko; Suzuki, Toshiya; Sakamoto, Keita; Kobayashi, Konomi; Shiozawa, Ayako; Hashimoto, Masao; Ishii, Satoru; Suzuki, Manabu; Hojo, Masayuki; Hasebe, Terumitsu; Sugiyama, Haruhito

doi:10.1007/s41030-019-00103-7

Cited by 4 publications

(5 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to the research conducted by Shota Yamamoto et al, 21 this study also revealed that baseline lung function [baseline FEV1 and baseline FEV1% predicted] might exert certain influence on BT activation number. Moreover, correlation and regression studies showed that total BT activations were not associated with clinical response to BT, except for a weak correlation ACQ improvement in the third BT session.…”

Section: Discussionsupporting

confidence: 88%

Correlation of Activation Site and Number with the Clinical Response to Bronchial Thermoplasty

Wang

Long

Huang

et al. 2022

JAA

View full text Add to dashboard Cite

Objective To investigate the relation of activation site and number with clinical response to bronchial thermoplasty (BT) in refractory asthma patients. Methods This work included 106 consecutive refractory asthma patients completing three BT sessions in our hospital from May 2016 to May 2019. Procedure details included recording delivery sites and those in BT. Asthma Control Questionnaire (ACQ) scores and spirometric measurements were recorded 1-day before treatment and 6 months post-treatment to explore the effects of BT activation number and site on clinical response. Results ACQ score (3.19±1.14 vs 1.26±0.63), forced expiratory volume in 1 sec (FEV1)% predicted (55.53±21.66 vs 66.19±22.50), FEV1 (1.53±0.74 vs 1.93±0.82), and forced vital capacity (FVC) (2.49±0.86 vs 2.92±0.94) significantly increased after three BT sessions compared with pre-session. Major bronchial ablation did not significantly improve BT response in asthma patients. Multivariate logistic regression identified baseline ACQ score and baseline FEV1% predicted as independent factors affecting the clinical response to BT. Correlation and regression analysis revealed a significant linear relationship between baseline ACQ and ACQ improvement, as well as a linear relationship between the third session activation number and ACQ improvement. Based on subgroup analysis of activation number, cohort C (activations ≥ 200) had better lung function, lower non-responding rate, and better long-term effectiveness than the other two cohorts. The activation number in the third BT session showed the strongest predictive ability compared with the first two sessions. Conclusion Main bronchial ablation did not markedly affect clinical response to BT. Baseline ACQ and baseline FEV1% predicted were independent factors affecting clinical response to BT. Increasing the activation number might promote the therapeutic efficacy of BT, and the activation number in the third BT session correlated with and predicted the BT response.

show abstract

Section: Discussionsupporting

confidence: 88%

Correlation of Activation Site and Number with the Clinical Response to Bronchial Thermoplasty

Wang

Long

Huang

et al. 2022

JAA

View full text Add to dashboard Cite

show abstract

“…However, in any study, the cumulative number of activations performed during 3 BT sessions was not associated with histological changes on bronchial biopsy (6). Some authors have proposed that the number of RF activations during BT is not associated with severe adverse events after BT (39). In contrast, others have concluded that an increased number of RF activations during BT results in a more significant number of serious adverse events.…”

Section: Problems and Prospectsmentioning

confidence: 70%

Recent advances in bronchial thermoplasty for severe asthma: a narrative review

Wu¹,

Li²,

Zhang³

et al. 2022

Ann Transl Med

View full text Add to dashboard Cite

Background and Objective: Severe asthma refers to asthma that requires step 4 or 5 therapy recommended by Global Initiative for Asthma (GINA) to prevent it from becoming uncontrolled or remaining "uncontrolled" despite this therapy. The poor treatment effect of severe asthma has been perplexing clinicians, which reduces the quality of life (QoL) of patients with asthma, and increases the mortality of such patients, so improving the therapeutic effect of severe asthma is an urgent problem to be solved in the clinic. Bronchial thermoplasty (BT) is a new non-drug therapy for severe asthma that is difficult to control with medications. It has been approved for clinical practice in China and the United States. The article aims at providing a new treatment option for patients with severe asthma that is poorly controlled by medications, thus improving the QoL in these patients.Methods: An extensive literature search was performed in the PubMed database, with "bronchial thermoplasty" as the key term. The full texts of all potentially relevant articles were obtained, and relevant information was extracted.

show abstract

“…Yamamoto S. et al also revealed that increase in the number of radiofrequency activations during BT is related to a decrease in FEV 1 and %FEV 1 from baseline. The number of radiofrequency activations, however, is not associated with SAEs including pneumonia after BT [17]. The patient presented herein received a total of 294 effective activations which were more than the average activations in practice [13].…”

Section: Discussionmentioning

confidence: 90%

Puzzling onsets of pneumonia sequentially after each session of bronchial thermoplasty: a case report

Nong

Lin

2020

BMC Pulm Med

View full text Add to dashboard Cite

Background: Bronchial thermoplasty (BT) is a novel bronchoscopic intervention for severe persistent asthma. An increase in transient respiratory adverse events associated with BT were noted over the treatment periods, however, these events appear sporadic and should not always recur in a single individual and BT-related pneumonia has rarely been reported. Case presentation: We present a case of uncontrolled severe asthma who developed puzzling pneumonia sequentially after each session of BT procedures. After each operation of three sequential BT procedures, she developed cough and purulent expectoration when her chest radiology showed new infiltrates right in the treatment regions. After empirical use of antibacterial agents plus physiotherapy and postural sputum drainage, her symptoms vanished and chest imaging resumed normal. Conclusion: The originality of our case report is related to the recurrence of pneumonia after three sequential BT procedures. To date, similar report has not been available in the literature. We hope to prompt alerts for post-BT respiratory infections, although most of them, along with other adverse events, are mild and tractable.

show abstract

Can the Number of Radiofrequency Activations Predict Serious Adverse Events after Bronchial Thermoplasty? A Retrospective Case-Control Study

Cited by 4 publications

References 21 publications

Correlation of Activation Site and Number with the Clinical Response to Bronchial Thermoplasty

Correlation of Activation Site and Number with the Clinical Response to Bronchial Thermoplasty

Recent advances in bronchial thermoplasty for severe asthma: a narrative review

Puzzling onsets of pneumonia sequentially after each session of bronchial thermoplasty: a case report

Contact Info

Product

Resources

About