Can the choice of diet undermine the potential genetic risk of AT1R 1166A&gt;C gene polymorphism?

Božina, Tamara; Lovrić, Jasna; Šimičević, Livija; Merkler, Ana; Božina, Mislav; Jelaković, Bojan; Sertić, Jadranka

doi:10.1016/j.gene.2018.09.004

Cited by 2 publications

(3 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Results of the studies reporting the role of AT1R gene A/C polymorphism as a risk factor for myocardial infarction are controversial. Some studies have reported a positive association, while other studies could not find this association [9,10,22,23]. This controversy may be due to differences in study populations, genetic background, study design, reporting bias, and publishing bias.…”

Section: Discussionmentioning

confidence: 99%

“…Various studies have suggested that the A/C1166 polymorphism of AT1R is a major risk factor for cardiovascular disorders. The AT1R mediate most harmful action of angiotensin II including the process of vascular hypertrophy, sodium retention, cardiac remodeling, hypertension and fibrinogenesis [22]. Results of the studies reporting the role of AT1R gene A/C polymorphism as a risk factor for myocardial infarction are controversial.…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown that AT1R expression is markedly increased in the CC homozygotes in comparison to AA and AC genotype carriers [24]. The C allele and the AC/CC genotypes are associated with significantly increased risk of CHD [9,10,22]. CC genotype get a risk of 1.74-fold of essential hypertension in Indian population and it has found that the AT1R gene might serve as a predictive marker for the hypertension susceptibility and causes the risk of hypertension stratification [25].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)

et al. 2019

View full text Add to dashboard Cite

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case-control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd's ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%