Can temporal fluctuation in spatial wall shear stress gradient initiate a cerebral aneurysm? A proposed novel hemodynamic index, the gradient oscillatory number (GON)

Shimogonya, Yuji; Ishikawa, Takuji; Imai, Yohsuke; Matsuki, Noriaki; Yamaguchi, Takami

doi:10.1016/j.jbiomech.2008.10.006

Cited by 131 publications

(112 citation statements)

References 18 publications

(17 reference statements)

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Section: Discussionmentioning

confidence: 72%

“…GON is the temporal fluctuation of the SWSSG over the cardiac cycle. 7 The formation of our patient's aneurysm at the area with high GON indicated cyclic mechanical stretching of the arterial wall as its possible cause.Kulcsár's group recently reported that CFD using preaneurysmal arterial geometry demonstrated an area with high WSS and high positive SWSSG at the location of future aneurysm formation in three of 3 bifurcation intracranial aneurysms. 5 Chen and colleagues reported that CFD calculation of the hypothetical healthy geometry of 22 cases revealed the greater correlation of future aneurysm formation with WSS and GON than SWSSG 6 and very low correlation with OSI.…”

mentioning

confidence: 72%

“…Calculation of CFD was about 3 hours using a 3.1-GHz CPU. We obtained WSS magnitude, 11 SWSSG magnitude, 4 oscillatory shear index (OSI), 12 and GON 7 based on their definitions shown in the appendix. We compared streamlines around the location of the future aneurysm before and after its formation and investigated whether there was an "area with high WSS and SWSSG" or an "area with high GON."…”

Section: Case Reportmentioning

confidence: 99%

“…Definitions of wall shear stress (WSS), 11 spatial WSS gradient (SWSSG), 4 oscillatory shear index (OSI), 12 and gradient oscillatory number (GON) 7 :…”

Section: Appendixmentioning

confidence: 99%

“…1 Although an area of relatively low and rotating wall shear stress (WSS) may cause an aneurysm to form, 2 high WSS is a more likely cause. 3 Recently proposed initiating causes of intracranial aneurysms include high WSS and high spatial WSS gradient (SWSSG) 4 -6 or high gradient oscillatory number (GON), 6,7 the index for the temporal fluctuation of the SWSSG over the cardiac cycle.…”

Section: Introductionmentioning

confidence: 99%

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MR-based Computational Fluid Dynamics with Patient-specific Boundary Conditions for the Initiation of a Sidewall Aneurysm of a Basilar Artery

et al. 2015

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We performed 3-dimensional cine phase-contrast magnetic resonance-based computational fluid dynamics for a basilar artery that developed a sidewall aneurysm over a 25-month period. There was an area with high gradient oscillatory number in the location of the future aneurysm ostium and an area with high wall shear stress (WSS) and high spatial WSS gradient at the distal edge of the future aneurysm. These could be biomarkers for development of intracranial aneurysms.Keywords: computational fluid dynamics, hemodynamics, intracranial aneurysms, magnetic resonance fluid dynamics, wall shear stress (WSS) IntroductionHemodynamics is thought to play very important roles in the initiation, progression, and rupture of intracranial aneurysms. The formation and regression of a flow-related cerebral aneurysm has been reported. 1 Although an area of relatively low and rotating wall shear stress (WSS) may cause an aneurysm to form, 2 high WSS is a more likely cause.3 Recently proposed initiating causes of intracranial aneurysms include high WSS and high spatial WSS gradient (SWSSG) 4 -6 or high gradient oscillatory number (GON), 6,7 the index for the temporal fluctuation of the SWSSG over the cardiac cycle.We performed 3-dimensional (3D) cine phasecontrast (PC) magnetic resonance (MR)-based computational fluid dynamics (CFD) with patient-specific boundary conditions for a basilar artery that developed a sidewall aneurysm at the ventral aspect of its distal portion over a 25-month period, and we investigated whether an area with high WSS and SWSSG or an area with high GON was present in and around the location of the aneurysm before it formed to predict future development of intracranial aneurysms. Case ReportOur institutional review board approved this study, and we obtained informed consent from the subject.An 88-year-old woman with heaviness of the head underwent MR examination including 3D time-of-flight (TOF) MR angiography (MRA) using *Corresponding author, Phone: +81-52-719-3154, Fax: +81-52-719-1509, E-mail: isoda@met.nagoya-u.ac.jp Magn Reson Med Sci, Vol. 14, No. 2, pp. 139-144, 2015 ©2015 (0.37 © 1 © 0.5 mm 3 with ZIP); bandwidth, 41.67 kHz; and imaging time, 5 min 29 s. Three-dimensional TOF MRA showed a 4-mm aneurysm at the bifurcation of the right middle cerebellar artery (MCA), a 3-mm aneurysm at the M1 segment of the left MCA, and ventral curving of the basilar artery without a distinct aneurysm (Fig. 1A, B). Because of the patient's age, her doctors determined that she should be followed closely without therapy.She underwent follow-up MR examination including 3D TOF MRA and 3D cine PC MR imaging 25 months after the initial examination. Imaging parameters for 3D TOF MRA were the same as those used previously; parameters for 3D cine PC MR imaging 8 were: TR/TE/NEX, 5.3 ms/2.3 ms/ 1; FA, 12 degrees; slab orientation, transaxial; FOV, 160 © 160 © 30 mm 3 ; matrix, 160 © 160 © 30 (160 © 160 © 60 with ZIP); voxel size, 1 © 1 © 1 mm 3 (1 © 1 © 0.5 mm 3 with ZIP); bandwidth, 62.5 kHz; number of phases, 20; velocit...

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Section: Discussionmentioning

confidence: 72%

mentioning

confidence: 72%

Section: Case Reportmentioning

confidence: 99%

“…Definitions of wall shear stress (WSS), 11 spatial WSS gradient (SWSSG), 4 oscillatory shear index (OSI), 12 and gradient oscillatory number (GON) 7 :…”

Section: Appendixmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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MR-based Computational Fluid Dynamics with Patient-specific Boundary Conditions for the Initiation of a Sidewall Aneurysm of a Basilar Artery

et al. 2015

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Vascular Geometric Singularities, Hemodynamic Markers and Pathologies

Deplano

Guivier-Curien

2022

Biological Flow in Large Vessels

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Topological flow structures and stir mixing for steady flow in a peripheral bypass graft with uncertainty

Gambaruto

Moura

Sequeira

2010

Numer Methods Biomed Eng

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SUMMARYWith growing focus on patient-specific studies, little attempt has yet been made to quantify the modelling uncertainty. Here uncertainty in both geometry definition obtained from in vivo magnetic resonance imaging scans and mathematical models for blood are considered for a peripheral bypass graft. The approximate error bounds in computed measures are quantified from the flow field in steady state simulations with rigid walls assumption.A brief outline of the medical image filtering and segmentation procedures is given, as well as virtual model reconstruction and surface smoothing. Diversities in these methods lead to variants of the virtual model definition, where the mean differences are within a pixel size. The blood is described here by either a Newtonian or a non-Newtonian Carreau constitutive model.The impact of the uncertainty is considered with respect to clinically relevant data such as wall shear stress. This parameter is locally very sensitive to the surface definition; however, variability in the topology has an effect on the core flow field and measures to study the flow structures are detailed and comparison performed. Integrated effect of the Lagrangian dynamics of the flow is presented in the form of stir mixing, which also has a strong clinical relevance.

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Can temporal fluctuation in spatial wall shear stress gradient initiate a cerebral aneurysm? A proposed novel hemodynamic index, the gradient oscillatory number (GON)

Cited by 131 publications

References 18 publications

MR-based Computational Fluid Dynamics with Patient-specific Boundary Conditions for the Initiation of a Sidewall Aneurysm of a Basilar Artery

MR-based Computational Fluid Dynamics with Patient-specific Boundary Conditions for the Initiation of a Sidewall Aneurysm of a Basilar Artery

Vascular Geometric Singularities, Hemodynamic Markers and Pathologies

Topological flow structures and stir mixing for steady flow in a peripheral bypass graft with uncertainty

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