Can tDCS enhance treatment of aphasia after stroke?

Holland, Rachel; Crinion, Jenny

doi:10.1080/02687038.2011.616925

Cited by 125 publications

(110 citation statements)

References 106 publications

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“…It may turn out that treatment features such as spacing of training [86] and opportunities for consolidation during sleep [87] could be as important as the specific materials used in intervention. An exciting recent development concerns the use of brain stimulation techniques-transcranial magnetic stimulation or transcranial direct current stimulation-as adjuncts to enhance language therapy [88,89].…”

Section: The Clinical Interface: Some Key Questionsmentioning

confidence: 99%

When words fail us: insights into language processing from developmental and acquired disorders

Bishop

Nation

Patterson

2014

Phil. Trans. R. Soc. B

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Acquired disorders of language represent loss of previously acquired skills, usually with relatively specific impairments. In children with developmental disorders of language, we may also see selective impairment in some skills; but in this case, the acquisition of language or literacy is affected from the outset. Because systems for processing spoken and written language change as they develop, we should beware of drawing too close a parallel between developmental and acquired disorders. Nevertheless, comparisons between the two may yield new insights. A key feature of connectionist models simulating acquired disorders is the interaction of components of language processing with each other and with other cognitive domains. This kind of model might help make sense of patterns of comorbidity in developmental disorders. Meanwhile, the study of developmental disorders emphasizes learning and change in underlying representations, allowing us to study how heterogeneity in cognitive profile may relate not just to neurobiology but also to experience. Children with persistent language difficulties pose challenges both to our efforts at intervention and to theories of learning of written and spoken language. Future attention to learning in individuals with developmental and acquired disorders could be of both theoretical and applied value.

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Section: The Clinical Interface: Some Key Questionsmentioning

confidence: 99%

When words fail us: insights into language processing from developmental and acquired disorders

Bishop

Nation

Patterson

2014

Phil. Trans. R. Soc. B

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“…The recent results obtained from TES experiments offer exciting possibilities for the enhancement and treatment of normal or impaired abilities, respectively [12][13][14]. These characteristics increase the likelihood of future use of TES with different populations, outside of the clinic and laboratory, in the home, office, and in educational institutes.…”

mentioning

confidence: 99%

Using transcranial electrical stimulation to enhance cognitive functions in the typical and atypical brain

Kadosh

2013

Translational Neuroscience

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Transcranial electrical stimulation (TES) includes methods such as transcranial direct current stimulation, transcranial random noise stimulation, and transcranial alternating current stimulation. These methods provide novel ways of enhancing human cognitive abilities for restorative purposes, or for general cognitive enhancement, by modulating neuronal activity. I discuss here the basic principles behind these methods and provide some illustrations of their efficacy in cognitive enhancement in those with typical and atypical brain function. Next, I outline some future directions for research that are have been largely neglected, such as the issue of individual differences, cognitive side effects, the efficacy of TES for use with healthy elderly populations, children with atypical development, and sports. The results observed thus far with TES as well as its future possibilities have significant implications for both basic and translational neuroscience.

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“…They showed favorable effects in speech performance for several weeks to a few months [reviews in [21,27]]. Only one study coupled ipsilesional anodal tDCS to language therapy in chronic nonfluent aphasia and observed improved speech/language performance for 1 week to 2 months [28].…”

Section: Introductionmentioning

confidence: 99%

Noninvasive Brain Stimulation for Treatment of Right- and Left-Handed Poststroke Aphasics

Heiss

Hartmann²,

Rubi-Fessen³

et al. 2013

Cerebrovasc Dis

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Background: Accumulating evidence from single case studies, small case series and randomized controlled trials seems to suggest that inhibitory noninvasive brain stimulation (NIBS) over the contralesional inferior frontal gyrus (IFG) of right-handers in conjunction with speech and language therapy (SLT) improves recovery from poststroke aphasia. Application of inhibitory NIBS to improve recovery in left-handed patients has not yet been reported. Methods: A total of 29 right-handed subacute poststroke aphasics were randomized to receive either 10 sessions of SLT following 20 min of inhibitory repetitive transcranial magnetic stimulation (rTMS) over the contralesional IFG or 10 sessions of SLT following sham stimulation; 2 left-handers were treated according to the same protocol with real rTMS. Language activation patterns were assessed with positron emission tomography prior to and after the treatment; 95% confidence intervals for changes in language performance scores and the activated brain volumes in both hemispheres were derived from TMS- and sham-treated right-handed patients and compared to the same parameters in left-handers. Results: Right-handed patients treated with rTMS showed better recovery of language function in global aphasia test scores (t test, p < 0.002) as well as in picture-naming performance (ANOVA, p = 0.03) than sham-treated right-handers. In treated right-handers, a shift of activation to the ipsilesional hemisphere was observed, while sham-treated patients consolidated network activity in the contralesional hemisphere (repeated-measures ANOVA, p = 0.009). Both left-handed patients also improved, with 1 patient within the confidence limits of TMS-treated right-handers (23 points, 15.9-28.9) and the other patient within the limits of sham-treated subjects (8 points, 2.8-14.5). Both patients exhibited only a very small interhemispheric shift, much less than expected in TMS-treated right-handers, and more or less consolidated initially active networks in both hemispheres. Conclusion: Inhibitory rTMS over the nondominant IFG appears to be a safe and effective treatment for right-handed poststroke aphasics. In the 2 cases of left-handed aphasics no deterioration of language performance was observed with this protocol. However, therapeutic efficiency is less obvious and seems to be more related to the dominance pattern prior to the stroke than to the TMS intervention.

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Can tDCS enhance treatment of aphasia after stroke?

Cited by 125 publications

References 106 publications

When words fail us: insights into language processing from developmental and acquired disorders

When words fail us: insights into language processing from developmental and acquired disorders

Using transcranial electrical stimulation to enhance cognitive functions in the typical and atypical brain

Noninvasive Brain Stimulation for Treatment of Right- and Left-Handed Poststroke Aphasics

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