Can Subclinical Rickets Cause SCFE? A Prospective, Pilot Study

Arkader, Alexandre; Woon, Regina P.; Gilsanz, Vicente

doi:10.1097/bpo.0000000000000562

Cited by 9 publications

(9 citation statements)

References 32 publications

(33 reference statements)

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“…On the other hand, Arkader et al. ( 2015 ) reported that all patients diagnosed with SCFE between the ages of 9 and 14 years had normal vitamin D levels. In their series of 15 cases with SCFE, Madhuri et al.…”

Section: Discussionmentioning

confidence: 99%

Obesity-related metabolic and endocrine disorders diagnosed during postoperative follow-up of slipped capital femoral epiphysis

et al. 2018

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Background and purposePatients with slipped capital femoral epiphysis (SCFE) are phenotypically overweight or obese and may therefore require clinical follow-up of obesity-related disorders. We evaluated obesity-related disorders such as dyslipidemia, type 2 diabetes mellitus (DM), and vitamin-D deficiency during the postoperative period in patients with SCFE.Patients and methods51 patients who were operated and followed-up for SCFE and 62 healthy adolescents without SCFE (control group) were included in this retrospective study. Patients’ BMI, serum lipid profile (total cholesterol, LDL-C, HDL-C, triglyceride), fasting blood glucose, HbA1c, and serum vitamin D levels were evaluated.ResultsAt the time of surgery, 45 patients in the SCFE group were overweight or obese (BMI >25). At the latest follow-up, 42 patients in the SCFE group and 53 patients in the control group were overweight/obese. Abnormal serum lipid profile and ratio of total dyslipidemia were similar between the groups. 8 patients had abnormal HbA1c levels in the SCFE group and mean HbA1c levels were significantly higher in the SCFE group (p = 0.03). All patients and controls had low levels of vitamin D.InterpretationAlthough serum lipid profile and vitamin D levels were detected as similar in SCFE and control groups, the potential risk of type 2 DM identified via abnormal HbA1c levels was significantly higher in patients with SCFE. We recommend that patients diagnosed with SCFE should be considered as potential candidates for type 2 DM; thus follow-up after surgical treatment should include not only orthopedic outcomes but also evaluation of future risk for DM.

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Section: Discussionmentioning

confidence: 99%

Obesity-related metabolic and endocrine disorders diagnosed during postoperative follow-up of slipped capital femoral epiphysis

et al. 2018

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“…Hypothyroidism has been shown to be one of the predominant laboratory findings 36 . Although some reports point to differences in bone mineralization testing results 38,39 (i.e., vitamin D, calcium, and parathyroid hormone) or renal osteodystrophy as a cause 37 , routine screening with these tests is typically not necessary and may not be discriminative in patients with or without SCFEs 74-76 . Other atypical presentations, including Klinefelter syndrome, have been reported 77 .…”

Section: Diagnosismentioning

confidence: 99%

“…Although some reports point to differences in bone mineralization testing results 38,39 (i.e., vitamin D, calcium, and parathyroid hormone) or renal osteodystrophy as a cause 37 , routine screening with these tests is typically not necessary and may not be discriminative in patients with or without SCFEs [74][75][76] .…”

Section: Differential Diagnosismentioning

confidence: 99%

Diagnosis and Management of Unstable Slipped Capital Femoral Epiphysis

Cazzulino

Allahabadi

et al. 2021

JBJS Reviews

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An unstable slipped capital femoral epiphysis (SCFE) is characterized by the inability to walk and is associated with a high risk of osteonecrosis.» An unstable SCFE is less common than a stable SCFE; however, the demographics are similar in both groups of patients with SCFE.» The diagnosis of an unstable SCFE is characterized by a history of antecedent pain and the inability to walk on examination, and it is confirmed by radiographic assessment.

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“…A study of 20 consecutive children from Los Angeles with SCFE and found no vitamin D deficiency, regardless of obesity status. The majority of the children studied were Hispanic (17 of 20), but the time of year when the vitamin D levels were collected was not given (21). In Vellore, India, all children with SCFE had significantly lower vitamin D levels than the controls (22).…”

Section: Scfementioning

confidence: 99%

Seasonal Variation in Slipped Capital Femoral Epiphysis: New Findings Using a National Children’s Hospital Database

Loder

Schneble

2019

Journal of Pediatric Orthopaedics

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Can Subclinical Rickets Cause SCFE? A Prospective, Pilot Study

Abstract: Although obese children are known to have lower levels of vitamin D and a higher prevalence of SCFE, we found no correlation between low vitamin D and the development of SCFE in this subset of patients.

Cited by 9 publications

References 32 publications

Obesity-related metabolic and endocrine disorders diagnosed during postoperative follow-up of slipped capital femoral epiphysis

Obesity-related metabolic and endocrine disorders diagnosed during postoperative follow-up of slipped capital femoral epiphysis

Diagnosis and Management of Unstable Slipped Capital Femoral Epiphysis

Seasonal Variation in Slipped Capital Femoral Epiphysis: New Findings Using a National Children’s Hospital Database

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