Can simulation measurements be used to predict the irradiated lung volume in the tangential fields in patients treated for breast cancer?

Bornstein, Bruce A.; Cheng, Chee Wai; Rhodes, Lois M.; Rashid, Harunor; Stomper, Paul C.; Siddon, Robert L.; Harris, Jay R.

doi:10.1016/0360-3016(90)90282-o

Cited by 101 publications

(38 citation statements)

References 9 publications

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“…The corresponding lung from an atlas could have been used as a template, provided, the atlas takes into account the factors that influence the volume and hence the area of the different slices of the lung. Registration becomes expensive due to the fact that lung volume varies with respect to several factors [14][15][16] and the lung size and shape differs between slices. Hence, in this work to reconstruct the convex border of the lung with severe pathology, the other lung from the same slice is used.…”

Section: Literature Surveymentioning

confidence: 99%

A Novel Supervised Approach for Segmentation of Lung Parenchyma from Chest CT for Computer-Aided Diagnosis

et al. 2012

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Segmentation of lung parenchyma from the chest computed tomography is an important task in analysis of chest computed tomography for diagnosis of lung disorders. It is a challenging task especially in the presence of peripherally placed pathology bearing regions. In this work, we propose a segmentation approach to segment lung parenchyma from chest. The first step is to segment the lungs using iterative thresholding followed by morphological operations. If the two lungs are not separated, the lung junction and its neighborhood are identified and local thresholding is applied. The second step is to extract shape features of the two lungs. The third step is to use a multilayer feed forward neural network to determine if the segmented lung parenchyma is complete, based on the extracted features. The final step is to reconstruct the two lungs in case of incomplete segmentation, by exploiting the fact that in majority of the cases, at least one of the two lungs would have been segmented correctly by the first step. Hence, the complete lung is determined based on the shape and region properties and the incomplete lung is reconstructed by applying graphical methods, namely, reflection and translation. The proposed approach has been tested in a computeraided diagnosis system for diagnosis of lung disorders, namely, bronchiectasis, tuberculosis, and pneumonia. An accuracy of 97.37 % has been achieved by the proposed approach whereas the conventional thresholding approach was unable to detect peripheral pathology-bearing regions. The results obtained prove to be better than that achieved using conventional thresholding and morphological operations.

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Section: Literature Surveymentioning

confidence: 99%

A Novel Supervised Approach for Segmentation of Lung Parenchyma from Chest CT for Computer-Aided Diagnosis

et al. 2012

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“…Simu las yon fil min de tan jan si yel ala nın ar ka ke na rı ile ön gö ğüs du va rı ara sın da ki dik me sa fe olan san tral ak ci ğer me sa fe si (CLD) öl çül müştür. 17 Rad yo te ra pi tek ni ği nin ak ci ğer hac mi ne et ki si bü yük oran da CLD'ye bağ lı bu lun muştur. CLD 1.5 cm ol du ğun da tan jan si yel alan da ki ak ci ğer hac mi yak la şık ola rak %6, CLD 2.5 cm iken, ışın lanan akci ğer hac mi yak la şık %16, CLD 3.5 cm ol du ğun da ışın lanan ip si la te ral ak ci ğer hac mi %26 ola rak hesap lan mış tır.…”

Section: Tar Tiş Maunclassified

“…CLD 1.5 cm ol du ğun da tan jan si yel alan da ki ak ci ğer hac mi yak la şık ola rak %6, CLD 2.5 cm iken, ışın lanan akci ğer hac mi yak la şık %16, CLD 3.5 cm ol du ğun da ışın lanan ip si la te ral ak ci ğer hac mi %26 ola rak hesap lan mış tır. 17 Bu me sa fe nin 3 cm'den faz la ol ma sı özel lik le sol me me de önem li de re ce de kalp ve ak ciğer hac mi nin ışın lan ma sı na ne den ol mak ta dır.…”

Section: Tar Tiş Maunclassified

Evaluation of Conventional Radiotherapy and Conformal Radiotherapy Technique in Terms of Dose Distribution Following Breast Conserving Therapy

Mayadağlı¹,

Gocen²,

Aksu³

et al. 2011

Turkiye Klinikleri J Med Sci

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Ö ÖZ ZE ET T A Am ma aç ç: : "Meme kanseri'' kadınlarda görülen en sık malign tümör çeşidi olup kansere bağlı ölüm nedenleri arasında ikinci sırada yer almaktadır. Meme kanserinde adjuvan radyoterapinin, lokal kontrolün yanında sağkalımı da artırdığı gösterilmiştir. Meme kanserinde erken tanı ve geliştirilen tedavi modaliteleri ile sağkalımdaki artma sonucu, tedavilere bağlı gelişen yan etki görülme sıklığı da artmıştır. Çalışmamızda meme radyoterapisinde kullanılan konvansiyonel 2 boyutlu radyoterapi (2DRT) ile 3 boyutlu konformal radyoterapi (3DRT) planlama tekniklerinde hedef meme dokusu ve çevre dokularının aldığı dozların karşılaştırılması amaçlanmıştır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Meme koruyucu cerrahi sonrası radyoterapi (RT) için başvuran 21 hastaya 2DRT planlanmıştır. Hastaların 2DRT planlama için simülatör cihazında çizimleri yapılmıştır. Hasta aynı gün bilgisayarlı tomografi (BT) simülatöre alınmıştır. 2DRT için çizilen tedavi alan girişleri ve kontür alınan kesit 3D plan üzerinde de gösterilmiştir. Hedef hacimleri belirlendikten sonra her hasta için iki RT planı yapılmıştır. 2DRT; hacmi ve dozu değiştirilmeden 3DRT'ye çevrilmiştir. B Bu ul lg gu ul la ar r: : Çalışmamızda düşük ve yüksek doz alan meme hacminin 2DRT planlama kolunda daha fazla olduğu, hedef dozu (50 Gy) alan meme hacminin ise 3DRT planlama kolunda standart verilere daha yakın olduğu görülmüştür. 3DRT kolunda hedef doz memeye daha iyi uygulanırken meme dokusundaki doz daha homojen olarak saptanmıştır. 2DRT kolunda meme doz dağılımı en belirgin konturdan alındığından doz dağılımı bu konturda normal iken memenin üst ve alt kısmında doku kalınlığının azalması nedeniyle hedef dozun üstüne toksik dozlara ulaşmaktadır. S So on nu uç ç: : 2DRT planlamada memeye uygun dozu vermek ve toksisiteyi değerlendirmek klinisyenler için zor bir karardır. Bu nedenle mümkün olduğunca meme tedavisinin 3DRT ile planlanması önerilmektedir.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Radyoterapi; meme tümörleri; sağkalım oranı A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Breast cancer is the most common cancer type among women and is the second leading cause of cancer-related deaths. Adjuvant radiotherapy has been shown to improve survival as well as local control. Frequency of adverse effects related to treatment has increased as the result of early diagnosis and developing treatment modalities in breast cancer. In our study, we compared the doses received by target breat tissue and neighbouring tissues in conventional 2-dimensional radiotherapy (2DRT) and 3-dimensional conformal radiotherapy (3DRT) planning techniques used in breast radiotherapy. M Ma a--t te er ri ia al l a an nd d M Me et th ho od ds s: : 2DRT was planned for 21 patients who were admitted for radiotherapy (RT) following breast conserving surgery. Drawings were done in simulator device for 2DRT planning. The patient was taken to computed tomography (CT) simulator on the same day. Treatment region entries drawn for 2DRT and the section that ...

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“…0026 mm. A CLD of 1.5 cm predicted that approximately 6% of the ipsilateral lung would be included in the tangential field, a CLD of 2.5 cm, approximately 16%, and a CLD of 3.5 cm, approximately 26% of the ipsilateral lung 18 .…”

Section: Patients Characteristicsmentioning

confidence: 99%

Institutional Validation of Posterior Margin Delineation For Conformal Radiotherapy of Breast Cancer Regarding Set-Up Errors Nemrock Experience

Abdelrahman

Safwat

2012

Kasr-Al-Aini J.of Clin. Onc. and Nuc. Med.

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Background and Aim of the Work: The benefit of post-operative loco-regional radiotherapy for high risk breast cancer patients in combination with systemic chemotherapy has been well established over the past two decades however radiation toxicity on normal tissues still constitute a significant clinical problem. Standard tangential breast radiotherapy does not only treat portions of the chest wall, but also exposes lung and heart tissue to radiation The aim of this work is to evaluate set-up error at our department (NEMROCK) in 3-D conformal radiotherapy of the post-operative irradiation of breast cancer in the anterior-posterior direction and compare this error to the added margin beyond pectoral fascia using the middle of the rib or rib/pleural interface deep margin method. Methodology:The maximum & minimum vertical distances between the pectoral fascia and the middle of the rib were measured on CT cuts for 30 patients and compared to the set-up error in the Maximum Lung Distance (MLD) after 2 weeks of irradiation by comparing Electronic portal images (EPI) to the Digitally Reconstructed Radiograph (DRR). results: The set-up error ranged from 2 to 6 mm with a mean value of 3.99 +/-2.99 mm. The maximum vertical distances between the pectoral fascia and the middle of the rib ranged from 1.83 cm. to 4.02 cm. with a mean value of 2.8695 +/-3.033 cm. The minimum vertical distances between the pectoral fascia and the middle of the rib ranged from 13 mm. to 14.3 mm and a mean of 13.26 +/-0. 0026 mm. conclusion: The use of the middle of the rib or rib/pleural interface as a deep margin may be an over estimation of the truly required margin. The use of 5-7 mm. margins beyond the pectoral fascia (or according to each institute set-up error) is more reasonable.

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Can simulation measurements be used to predict the irradiated lung volume in the tangential fields in patients treated for breast cancer?

Cited by 101 publications

References 9 publications

A Novel Supervised Approach for Segmentation of Lung Parenchyma from Chest CT for Computer-Aided Diagnosis

A Novel Supervised Approach for Segmentation of Lung Parenchyma from Chest CT for Computer-Aided Diagnosis

Evaluation of Conventional Radiotherapy and Conformal Radiotherapy Technique in Terms of Dose Distribution Following Breast Conserving Therapy

Institutional Validation of Posterior Margin Delineation For Conformal Radiotherapy of Breast Cancer Regarding Set-Up Errors Nemrock Experience

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