Can shear wave ultrasound elastography be a useful tool for determining the tumor extent of basal cell carcinomas pre‐operatively? A preliminary study

Ünal, Mehmet; İslamoğlu, Zeynep Gizem Kaya; Öztürk, Mehmet; Uysal, Emine; İslamoğlu, Necat

doi:10.1111/srt.12769

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…However, this infiltration of tumor cells into the normal tissue changes the structure, therefore the stiffness of this region increases, as the shear wave propagates through this structure, its propagation velocity changes. In 2020, Unal et al 15 found a progressive decrease in stiffness of central BCC, marginal BCC and perilesional normal skin. In our study, E ave and E sd measured at RTM were indeed greater than OSM on the same margin specimens, but the difference between RTM and OSM for these two parameters was not statistically significant, probably because the patient's age, sunshine exposure time and the location of skin all had a greater effect on the stiffness of the skin 16 .…”

Section: Discussionmentioning

confidence: 99%

Usefulness of Shear Wave Elastography in Determining the Tumor Extent of Basal Cell Carcinomas

Liang

Feng

Wang

et al. 2022

J of Ultrasound Medicine

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Objectives-The purpose of this study was to investigate the value of shear wave elastography (SWE) in determining tumor extent of basal cell carcinomas (BCC), and thereby determine the optimal surgical margins (OSM).Methods-10 patients (40 surgical margins) with BCC were collected, the visual observation boundaries (VOB) were marked, and the SWE parameters of soft tissues were measured 1 mm intervals in "3, 6, 9, 12" clock directions, starting from VOB. Then tumors were resected with a 5 mm surgical margin outward expansion of VOB. All specimens were examined pathologically 1 mm intervals from VOB in four clock directions. With the positive margins furthest from the tumor as the real tumor boundaries (RTB) and the negative margins closest to the tumor as the optimal surgical margins (OSM). The SWE parameters were compared between these two groups.Results-The elasticity ratio (E ratio ) of average young's modulus between region of interest and adjacent normal soft tissue had statistically significant differences between groups (P = .000), while other parameters show no difference. The E ratio of RTB and OSM were 1.22 AE 0.14 and 0.99 AE 0.07. The area under the ROC curve was .947. Taking 1.075 as the threshold of E ratio for the diagnosis of tumor extent, the sensitivity, specificity and accuracy were 87.5%, 90.0% and 90.0%. The surgical margins designed according to OSM were better than those designed according to VOB + 5 mm (P = .000).Conclusions-The E ratio of SWE is helpful in determining tumor extent of BCC. This is beneficial for surgical margin designing.

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Section: Discussionmentioning

confidence: 99%

Usefulness of Shear Wave Elastography in Determining the Tumor Extent of Basal Cell Carcinomas

Liang

Feng

Wang

et al. 2022

J of Ultrasound Medicine

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“…Recently, elastography has been proven useful in the differentiation of malignant and benign skin lesions, preoperative assessment of the depth and border of skin cancers, and the predication of lymph node involvement. 29 , 30 , 31 In theory, elastography is also potentially useful in quantitatively differentiating high‐risk BCC and cSCC. However, there were some limitations in the clinical practice of elastography.…”

Section: Discussionmentioning

confidence: 99%

High‐frequency ultrasound for differentiation between high‐risk basal cell carcinoma and cutaneous squamous cell carcinoma

Chen

Yan

Zhu

et al. 2021

Skin Research and Technology

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Background:The similar visual appearance of high-risk basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) may cause confusion for diagnosis.High-frequency ultrasound (HFUS) may provide additional intralesional information and thus help to distinguish them. Method:In this retrospective study, we analyzed the clinical characteristics, HFUS grayscale, and color Doppler flow imaging (CDFI) features of pathologically confirmed high-risk BCC and cSCC lesions (n = 65 vs n = 68). Subsequently, discrimination models based on the significant HFUS features were established. Results:Between high-risk BCC and cSCC lesions, the HFUS grayscale features of the lesion size (10.0 mm vs 17.4 mm), thickness (3.1 mm vs 5.9 mm), internal hyperechoic spots (80.0% vs 23.5%), and posterior acoustic shadowing (16.9% vs 66.2%) were statistically different (all p < 0.001). As for the CDFI features, high-risk BCC lesions mainly appeared as pattern II (47.7%), while cSCC lesions mainly appeared as pattern III (66.2%). Based on the above five features, an optimal discrimination model was established with a sensitivity of 91.2%, a specificity of 87.7%, and an accuracy of 89.5%. Conclusion:HFUS features, including size, thickness, internal hyperechoic spots, posterior acoustic shadowing, and Doppler vascularity pattern, are useful for differential diagnosis between high-risk BCC and cSCC.

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Can shear wave ultrasound elastography be a useful tool for determining the tumor extent of basal cell carcinomas pre‐operatively? A preliminary study

Cited by 2 publications

References 6 publications

Usefulness of Shear Wave Elastography in Determining the Tumor Extent of Basal Cell Carcinomas

Usefulness of Shear Wave Elastography in Determining the Tumor Extent of Basal Cell Carcinomas

High‐frequency ultrasound for differentiation between high‐risk basal cell carcinoma and cutaneous squamous cell carcinoma

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