Can serum fibrosis markers predict medium/large oesophageal varices in patients with liver cirrhosis?

Level of γ-glutamyltransferase in 2-Year-old Children With Biliary Atresia Associates With Progression of Portal Hypertension

“…This study links serum GGT levels at age 2 to future platelet counts, perhaps as a surrogate for the development of portal hypertension and its clinical consequences. [5][6][7][8] Because the sequelae of portal hypertension in BA SNL often occurs slowly, 9 larger long-term studies are needed to identify if GGT levels at age 2 predict sentinel clinical events during childhood, adolescence, and young adulthood. Finally, if validated, GGT levels may ultimately participate in modeling the natural history, and evaluating the response to therapeutic interventions, in BA SNL patients.…”

Towards Noninvasive Detection of Oesophageal Varices

“…Conflicting results have been demonstrated. Galal et al [23] assessed the ability of serum hyaluronic acid to predict medium-to-large oesophageal varices and showed the sensitivity, specificity, positive and negative predictive values, and diagnostic accuracy at a cutoff of 207  μ g/L to be 94%, 77.8%, 88.7%, 87.5%, and 88.3%, respectively. Körner et al [24] showed no association between concentrations of hyaluronic acid or laminin and grade of oesophageal varices, and a further study by Bahr et al [25] confirmed the lack of association of serum laminin to size of oesophageal varices.…”

Hyaluronic acid as a non-invasive biomarker of liver fibrosis

“…HA levels were elevated in cirrhotic patients, and were higher compared to non-cirrhotic HCC patients (111). HA levels were further elevated in cirrhotic HCC patients compared to non-cirrhotic HCC patients (110,111).…”

“…Moreover, it is mandatory to determine ways to effectively disseminate knowledge of the assays and procedures from current experts to trainees. Lower expression of HA associated with lower levels of TGF-β1 Liver stiffness was measured by transient elastography using Fibroscan Table 4: HA: hyaluronic acid; HCC: hepatocellular carcinoma; HCV: hepatitis C virus; IQR: interquartile range; NPV: negative predictive value; PPV: positive predictive value Serum HA was measured by Corgenix (Broomfield, CO) (101,105,110,111) Serum HA was measured by ELISA (Osteomedical, Bünde, Germany) (102) Serum HA was measured by ELISA (Echelon Biosciences Inc., Salt Lake City, UT) (106, 113) Serum HA was measured by ELISA (R&D Systems, Minneapolis, MN) (108) Serum HA was measured by ELISA (Shanghai High Medical Biotech, Shanghai, China) (HA reference value: <104.9 ng/mL) (109) ELF assessed by Siemens Bayer ADVIA Centaur® CP Immunoassay System (Tarrytown, NY) (112) Fibrosis assessed in biopsy by Metavir (101,105,109) Fibrosis assessed in biopsy Scheuer classification (102,103,112) Fibrosis assessed in biopsy by Chinese criteria for fibrosis (F0-4) (108)  Hyaluronic acid (HA) is a non-invasive biomarker, used alone or in combination with other markers to determine the degree of fibrosis.…”

“…HA and PIIINP were serum markers of fibrogenesis in a sample of 63 ALD patients and 57 heavy drinkers without apparent ALD (100). Table 4 describes studies in individuals with other types of liver diseases (101)(102)(103)(104)(105)(106)(107)(108)(109)(110)(111)(112)(113). Several of these studies involve heterogeneous liver disease populations, comprising of patients suffering from viral, autoimmune, chemical-induced, drug-induced or alcohol-induced liver injury.…”