Can sealing promote healing?: A systematic review and meta-analysis highlighting the adjunctive role of tissue sealant application during urethroplasty for hypospadias

Singh, Apoorv; Anand, Sachit; Goel, Prabudh; Yadav, Devendra Kumar; Bajpai, Minu

doi:10.1016/j.jpurol.2021.07.011

Cited by 13 publications

(11 citation statements)

References 19 publications

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“…Our analysis showed that conventional dressings are associated with higher risk of re-operations, without any significant differences with respect to urethroplasty and wound-related complications between the two dressing categories. These results are substantially in accordance with a recently published systematic review and meta-analysis, that highlighted no additional benefit of tissue sealant application during hypospadias repair 8 . The overall complication rates were comparable among the sealant and no sealant treatment groups, although significant reduction in the occurrence of some specific complications, including urethrocutaneous fistula, wound-related complications and complications involving the neourethra was observed with sealant application 8 .…”

Section: Discussionsupporting

confidence: 92%

“…Various types of dressings ranging from glove-finger and adhesive tape-based to tissue sealants and ozonated products have been explored by surgeons across the world 7 . Tissue sealants are one such option that has gained significant attention in the recent years 8 . Application of tissue sealant can provide an additional coverage to the suture line and reduce the risk of post-operative complications 8 .…”

Section: Introductionmentioning

confidence: 99%

“…Tissue sealants are one such option that has gained significant attention in the recent years 8 . Application of tissue sealant can provide an additional coverage to the suture line and reduce the risk of post-operative complications 8 . Various studies have shown mutually opposite results and have generated a debate among hypospadiologists regarding tissue sealants' application during hypospadias repair 7,8 .…”

Section: Introductionmentioning

confidence: 99%

“…Application of tissue sealant can provide an additional coverage to the suture line and reduce the risk of post-operative complications 8 . Various studies have shown mutually opposite results and have generated a debate among hypospadiologists regarding tissue sealants' application during hypospadias repair 7,8 . More recently, new products, such as ozonated oily-based gel, are gaining wide acceptance for topical use in difficult wound lesions, such as diabetic foot or trophic ulcers 9 .…”

Section: Introductionmentioning

confidence: 99%

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The Role of Postoperative Dressing in Hypospadias Surgery: A Systematic Review and Meta-analysis of the Pediatric Literature

et al. 2023

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Introduction: This study aimed to describe the available dressings and their management in patients undergoing hypospadias repair and compare post-operative outcomes with and without dressing and between the different dressing types. Materials and Methods: A comprehensive electronic literature search of PubMed, Embase, and Cochrane Library was conducted to obtain studies, published in the period 1990-2021, reporting on the dressing used following hypospadias surgery. All information regarding the dressing were considered as primary end points whereas surgical outcomes were assessed as secondary outcomes. Results: Thirty-one studies containing 1790 subjects undergoing hypospadias repair were included. Dressings were divided into 3 categories: non-adherent to the wound, adherent to the wound and glue-based dressings. Most authors preferred to remove/change the dressing in the ward and the median time of removal/change was 6.56 post-operative days. The dressing removal appeared as the most frequent factor generating parental anxiety. The median rate of wound-related complications was 8.18%, of urethroplasty complications 9.08% and of re-operations 8.18%. Metanalysis of outcomes showed higher risk of re-operations using conventional dressing, with no differences in urethroplasty and wound-related complications rates between conventional and glue-based dressings. Furthermore, use of dressing reported increased risk of wound-related complications compared with no dressing, without significant differences regarding occurrence of urethroplasty complications and re-operations. Conclusions: The current evidence confirmed that there is no difference in outcomes of hypospadias repair depending on a certain dressing type. To date, surgeon’s preference remains the main factor determining the choice for a specific dressing or for no dressing at all.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Role of Postoperative Dressing in Hypospadias Surgery: A Systematic Review and Meta-analysis of the Pediatric Literature

et al. 2023

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“…And the study describing the number of withdrawals or loss of follow-up cases and explaining the reasons was worth 1 point. The measurement of the researcher agreement was done using kappa statistics [ 22 ]. Based on the kappa values, the level of agreement was defined as almost perfect (0.81–1.00), substantial (0.61–0.80), moderate (0.41–0.60), fair (0.21–0.40), slight (0.00–0.20), and poor (<0.00).…”

Section: Methodsmentioning

confidence: 99%

Clinical Evidence and Potential Mechanisms of Complementary Treatment of Ling Gui Zhu Gan Formula for the Management of Serum Lipids and Obesity

Sun

Liu

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. This study aims to evaluate the clinical effects of Ling Gui Zhu Gan formula (LGZG), a famous TCM formula, for the management of serum lipids and obesity and preliminarily elucidates the bioactive components and the potential mechanism. Methods. Cluster analysis was adopted to investigate the TCM herbs and their frequency of occurrence for treating hyperlipidemia and obesity in an academic experience database of Chinese famous TCM doctors (http://www.gjmlzy.com:83). Then, relevant randomized controlled trials (RCTs) about LGZG supplementation in improving lipid levels and obesity were retrieved and analyzed. Lastly, the integration of network pharmacology, as well as greedy algorithms, which are theoretically well founded for the set cover in computer science, was exploited to identify the bioactive components of LGZG and to reveal potential mechanisms for attenuation or reversal of hyperlipidemia and obesity. Results. Based on the cluster analysis of 104 cases in TCM academic experience database, four TCM herbs in LGZG showed high-use frequency for treating hyperlipidemia and obesity. Meta-analysis on 19 randomized controlled trials (RCTs) with 1716 participants indicated that LGZG supplementation significantly decreased the serum levels of total triglycerides, total cholesterol, low-density lipoprotein cholesterol, BMI, and body weight and increased high-density lipoprotein cholesterol, compared with clinical control groups. No serious adverse effect was detected in all studies. Twenty-one bioactive components of LGZG, mainly flavonoids (i.e., naringenin, kaempferol, and kumatakenin), saponins (i.e., hederagenin), and fatty acids (i.e., eicosenoic acid), had the potential benefits possibly by regulating multiple targets such as PTPN1, CYP19A1, and ESR2, as well as a few complex pathways including the TNF signaling pathway, PPAR signaling pathway, arachidonic acid metabolism, fat digestion, and absorption. Conclusion. The present study has proved the clinical value of LGZG as a complementary treatment for attenuation or reversal of hyperlipidemia and obesity. More high-quality clinical and experimental studies in the future are demanded to verify its effects and the precise mechanism of action.

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The role of tissue adhesives and sealants in colorectal anastomotic healing—a scoping review

Valsamidis,

Rasmussen,

Eriksen

et al. 2023

Int J Colorectal Dis

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Can sealing promote healing?: A systematic review and meta-analysis highlighting the adjunctive role of tissue sealant application during urethroplasty for hypospadias

Cited by 13 publications

References 19 publications

The Role of Postoperative Dressing in Hypospadias Surgery: A Systematic Review and Meta-analysis of the Pediatric Literature

The Role of Postoperative Dressing in Hypospadias Surgery: A Systematic Review and Meta-analysis of the Pediatric Literature

Clinical Evidence and Potential Mechanisms of Complementary Treatment of Ling Gui Zhu Gan Formula for the Management of Serum Lipids and Obesity

The role of tissue adhesives and sealants in colorectal anastomotic healing—a scoping review

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