Can Reflux Symptom Index and Reflux Finding Score Be Used to Guide the Treatment of Secretory Otitis Media in Adults?

Pang, Kaiyun; Di, Yuanzhi; Li, Guodong; Li, Jianfeng; Xin, Li; Sun, Lu

doi:10.1159/000505929

Cited by 4 publications

(3 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This not only further proved that LPRD can be involved in the occurrence and progression of OME by affecting ET function, but also suggested that the simple RSI score could be used as a reference for anti-reflux therapy in adult OME patients. As the ET dysfunction evaluated by TMM method had been proved to be associated with ineffective conservative treatments ( 4 , 5 ), the clinical research conducted by Pang et al had proved the potential advantages of acid-suppressive drugs in OME patients with abnormal RSI results ( 22 ). Our results further suggested that the mechanism may be attributed to the prevention of LPRD in disrupting ET patency.…”

Section: Discussionmentioning

confidence: 99%

Laryngopharyngeal reflux as a potential cause of Eustachian tube dysfunction in patients with otitis media with effusion

et al. 2022

View full text Add to dashboard Cite

ObjectiveTo explore the association between laryngopharyngeal reflux disease (LPRD)-related symptoms and the Eustachian tube (ET) function in adult patients with otitis media with effusion (OME).Materials and methodsA total of 105 adult patients with OME were retrospectively studied. All these patients had undergone tubomanometry (TMM) test for the affected ears before treatments. The LPRD-related symptoms were all assessed by the Reflux Symptom Index (RSI) scale.ResultsAmong the 105 included patients, the numbers of subjects with only one and both two ears affected were 65 (57.1%) and 40 (42.9%), respectively. Therefore, a total of 145 affected ears were studied. For these affected ears, a linear regression analysis that included sex, age, BMI, smoking history, drinking history, RSI value, and the condition of the contralateral ear suggested that only RSI value was significantly associated with TMM value (P < 0.001), with the correlation coefficient of −0.112. Among the 9 symptoms in RSI scale, affected ears with the following symptoms (vs. affected ears without) showed significantly lower TMM values: excess throat mucus or postnasal drip, difficulty swallowing food, liquids, or pills, and sensations of something stuck in your throat or a lump in your throat (all P < 0.05).ConclusionLPRD may disrupt ET function in adult OME patients. A higher RSI score is independently predictive for a bad ET patency in such patients and is indicative for an additional anti-reflux therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Laryngopharyngeal reflux as a potential cause of Eustachian tube dysfunction in patients with otitis media with effusion

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Although we demonstrated significant findings, there are several limitations that should be considered in future research. First, GERD and chronic OME were identified only by the diagnostic code without information such as severity of reflux, reflux symptom index, reflux finding score, or physical examination findings [23] . However, we tried to improve the diagnostic accuracy of GERD by including patients who underwent at least one of the following tests: esophageal 24-hour pH monitoring, upper gastrointestinal endoscopy, and laryngoscopy, and who were prescribed anti-GERD medication for >4 weeks.…”

Section: Discussionmentioning

confidence: 99%

Association of gastroesophageal reflux disease with increased risk of chronic otitis media with effusion in adults

2021

View full text Add to dashboard Cite

This study aimed to evaluate the risk of developing chronic otitis media with effusion (OME) in individuals with gastroesophageal reflux disease (GERD).A retrospective propensity score-matched cohort study was performed using data from the Korea National Health Insurance Service. The GERD group (n = 3532) included certain individuals who had been diagnosed with GERD between January 2002 and December 2005. A comparison control group (n = 14,128) was calculated by 1:4 propensity score matching considering age, sex, and comorbidities and year of enrollment. Each patient was monitored until 2013. Survival analysis, the Log-rank test, and Cox proportional hazard regression models were used to calculate the incidence, survival rate, and hazard ratio (HR) of chronic OME for each group.Among the 17,660 individuals included in the study population (53.2% men), the overall incidence of chronic OME during the 11-year follow-up was 1.84-fold higher in the GERD group than in the non-GERD group (1.8 vs 3.0 per 1000 person-year; adjusted HR 1.84; 95% confidence interval [CI], 1.46–2.31). Moreover, the adjusted HRs of developing chronic OME (allergic rhinitis, 1.69 [95% CI, 1.37–2.10]; asthma, 1.29 [95% CI, 1.02–1.64]; chronic rhinosinusitis, 1.61 [95% CI, 1.26–2.05]) were greater in study population with comorbidities.From long-term follow-up, the prevalence of chronic OME in adults was 1.84 times higher in the GERD group compared with the non-GERD group. Specifically, it found that allergic rhinitis, asthma, or chronic rhinosinusitis showed increase the risk of developing chronic OME than those without these conditions.

show abstract

“…Although we demonstrated significant findings, there are several limitations that should be considered in future research. First, GERD and chronic OME were identified only by the diagnostic code without information such as severity of reflux, reflux symptom index, reflux finding score or physical examination findings [23] . However, we tried to improve the diagnostic accuracy of GERD by including patients who underwent at least one of the following tests: esophageal 24-hour pH monitoring, upper gastrointestinal endoscopy, and laryngoscopy, and who were prescribed anti-GERD medication for more than 4 weeks.…”

Section: Discussionmentioning

confidence: 99%

Association of gastroesophageal reflux disease with increased risk of chronic otitis media with effusion in adults

2021

View full text Add to dashboard Cite

This study aimed to evaluate the risk of developing chronic otitis media with effusion (OME) in individuals with gastroesophageal reflux disease (GERD).A retrospective propensity score-matched cohort study was performed using data from the Korea National Health Insurance Service. The GERD group (n = 3532) included certain individuals who had been diagnosed with GERD between January 2002 and December 2005. A comparison control group (n = 14,128) was calculated by 1:4 Propensity Score (PS) matching considering age, sex, and comorbidities and year of enrolment. Each patient was monitored until 2013. Survival analysis, the log-rank test, and Cox proportional hazard regression models were used to calculate the incidence, survival rate, and hazard ratio (HR) of chronic OME for each group.Among the 17,660 individuals included in the study population (53.2% male), the overall incidence of chronic OME during the 11year follow-up was 1.84-fold higher in the GERD group than in the non-GERD group (1.8 vs 3.0 per 1000 person-year; adjusted HR 1.84; 95% confidence interval [CI], 1.46-2.31). Moreover, the adjusted HRs of developing chronic OME (allergic rhinitis, 1.69 [95% CI, 1.37-2.10]; asthma, 1.29 [95% CI, 1.02-1.64]; chronic rhinosinusitis, 1.61 [95% CI, 1.26-2.05]) were greater in study population with comorbidities.From long-term follow-up, the prevalence of chronic OME in adults was 1.84 times higher in the GERD group compared with the non-GERD group. Specifically, it found that allergic rhinitis, asthma, or chronic rhinosinusitis showed increase the risk of developing chronic OME than those without these conditions.

show abstract

Can Reflux Symptom Index and Reflux Finding Score Be Used to Guide the Treatment of Secretory Otitis Media in Adults?

Cited by 4 publications

References 20 publications

Laryngopharyngeal reflux as a potential cause of Eustachian tube dysfunction in patients with otitis media with effusion

Laryngopharyngeal reflux as a potential cause of Eustachian tube dysfunction in patients with otitis media with effusion

Association of gastroesophageal reflux disease with increased risk of chronic otitis media with effusion in adults

Association of gastroesophageal reflux disease with increased risk of chronic otitis media with effusion in adults

Contact Info

Product

Resources

About