Can Red Blood Cell and Platelet Transfusions Have a Pathogenic Role in Bronchopulmonary Dysplasia?

Bahr, Timothy M.; Snow, Gregory L.; Christensen, Thomas R.; Davenport, Patricia; Henry, Erick; Tweddell, Sarah M.; Ilstrup, Sarah J.; Yoder, Bradley A.; Ohls, Robin K.; Sola-Visner, Martha C.; Christensen, Robert D.

doi:10.1016/j.jpeds.2023.113836

Cited by 2 publications

(2 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The pathogenesis of these adverse outcomes of ELGANs is incompletely known, but associations with red blood cell (RBC) transfusions have been observed [4][5][6][7][8][9][10][11][12][13][14]. Puia-Dumitrescu et al reported that neonates weighing < 1000 grams at birth admitted to the Duke University Medical Center received a median of eight RBC transfusions (25th and 75th percentiles; 5, 10) [15].…”

Section: Introductionmentioning

confidence: 99%

“…When adult red blood cells are transfused into ELGANs they might have a greater propensity to congest in tight portions of the microcirculation, resulting in reduced regional perfusion [19]. Another potential problem with transfusing adult blood to ELGANs is the proin ammatory propensity of adult blood, compared with more immunologically naïve cord blood [13,20,21].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Banked term umbilical cord blood to meet the packed red blood cell transfusion needs of extremely-low-gestational-age neonates: a feasibility analysis

Christensen,

Bahr,

Christensen

et al. 2023

J Perinatol

Self Cite

View full text Add to dashboard Cite

OBJECTIVES: To assess the feasibility of drawing, processing, safety-testing, and banking term umbilical cord blood to meet the packed red blood cell transfusion (RBC Tx) needs of extremely-low-gestational-age neonates (ELGANs).DESIGN: 1) Retrospectively analyze all ELGANs RBC Tx over the past three years, 2) Estimate local cord blood availability, 3) Assess interest in this project, and implementation barriers, through stakeholder surveys.RESULTS: In three years we cared for 266 ELGANs; 165 (62%) received ≥1 RBC Tx. Annual RBC Tx averaged 197 (95% CI, 152 -243). If 10% of our 10,353 annual term births had cord blood drawn and processed, and half of those tested were acceptable for Tx, collections would exceed the 95 th % upper estimate for need by >four-fold. Interest exceeded 97%. Identi ed barriers included FDA approval, training to collect cord blood, and cost. CONCLUSION: RBC Tx needs of ELGANS could be met by local cord blood collection.

show abstract