2011
DOI: 10.1002/cncr.26317
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Can radicality of surgery be safely modulated on the basis of MRI and PET/CT imaging in locally advanced cervical cancer patients administered preoperative treatment?

Abstract: BACKGROUND:The goal of this study was to prospectively analyze the diagnostic performances of magnetic resonance imaging (MRI) and positron emission tomography (PET)/computed tomography (CT) in predicting pathologically assessed residual disease in a large, single-institution series of locally advanced cervical cancer (LACC) patients triaged to neoadjuvant treatments followed by radical surgery. METHODS: Between April 2007 and March 2010, 96 patients with histologically documented cervical cancer (any histolog… Show more

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Cited by 39 publications
(33 citation statements)
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References 29 publications
(35 reference statements)
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“…The use of MR imaging enables a more appropriate triaging of patients to hysterectomy if the tumor is confined to the cervix and < 4 cm in size, or chemo-radiation if tumor size exceeds 4 cm or parametrial invasion is present. Although recent multi-institutional trials have raised concerns about the accuracy of cross-sectional imaging in the staging of early cervical cancer (stage < IIB), MRI still remains the best imaging technique for assessment of tumor size, with a high negative predictive value in excluding parametrial invasion (22-26). …”
Section: Introductionmentioning
confidence: 99%
“…The use of MR imaging enables a more appropriate triaging of patients to hysterectomy if the tumor is confined to the cervix and < 4 cm in size, or chemo-radiation if tumor size exceeds 4 cm or parametrial invasion is present. Although recent multi-institutional trials have raised concerns about the accuracy of cross-sectional imaging in the staging of early cervical cancer (stage < IIB), MRI still remains the best imaging technique for assessment of tumor size, with a high negative predictive value in excluding parametrial invasion (22-26). …”
Section: Introductionmentioning
confidence: 99%
“…Therefore, this study confirms previous reported data that MRI cannot accurately predict the presence of RD after primary CRT, disallowing the option of avoiding or modulating completion surgery exclusively based on radiology. 9,19 In this scenario, the exact role of positron emission tomography/CT is also a matter of great discussion. It may be more accurate for the detection of microscopic residual cervical cancer than MRI, but available studies are limited by low numbers of analyzed patients.…”
Section: Discussionmentioning
confidence: 99%
“…Laparoscopy reduces significant procedure-related morbidity and expedites recovery. 9 Besides, image magnification, proper dissection in critical areas, and lower blood loss are additional advantages. 29 On the other hand, several important oncological concerns have limited the widespread use of laparoscopyVpossible inadequate staging, port-site metastasis, and cancer cell dissemination.…”
Section: Discussionmentioning
confidence: 99%
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“…They proposed an analysis to compare the value of MRI with clinical examination in staging of uterus cervical carcinoma (UCC), which remains the second most commonly diagnosed cancer among female patients and the effective approaches towards UCC rely heavily on the precise pre-surgical staging [5][6][7][8]. The conventional International Federation of Gynecology and Obstetrics (FIGO) system based on clinical examination is being applied worldwide for UCC staging.…”
mentioning
confidence: 99%