Can pulmonary sclerosing haemangioma be accurately diagnosed by intra‐operative frozen section?

Chan, Alex; Chan, John K.

doi:10.1046/j.1365-2559.2002.01461.x

Cited by 30 publications

(28 citation statements)

References 19 publications

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“…A previous study showed intraoperative frozen sections were able to avert extensive surgical resection in two-thirds of patients with pulmonary sclerosing hemangioma. 19 Our experience showed an error rate of 25% and a deferred rate of 31%, which were higher than those described for lymphoma and carcinoid (error rate, 18%; deferred rate, 10%). 20 This resulted in nearly half of our patients undergoing unnecessary extensive surgical procedures.…”

Section: Discussioncontrasting

confidence: 51%

Pulmonary sclerosing hemangioma: pitfalls in management

Low

Teo

Eng

et al. 2011

Asian Cardiovasc Thorac Ann

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Pulmonary sclerosing hemangioma is a rare benign tumor for which surgical excision is curative with an excellent prognosis. It often mimics malignancy, making it a diagnostic and management challenge. We reviewed the clinical, radiological, and histopathological characteristics as well as the surgical management of our patients to assess the potential pitfalls in management. All 19 patients who underwent surgical biopsy between January 1999 and December 2009 with a final histopathological diagnosis of pulmonary sclerosing hemangioma were reviewed retrospectively. The median age was 48 years, 89.5% were female, 89.5% were Chinese, and 68.4% were asymptomatic. There were no specific diagnostic radiological characteristics; 1 of 3 patients who underwent combined positron-emission and computed tomography had a false-positive result. Preoperative attempts at establishing a diagnosis were successful in 20% of patients who had invasive procedures. Intraoperative frozen-section evaluation for pulmonary sclerosing hemangioma had an error rate of 25% and a deferred rate of 31%, resulting in nearly half of our patients undergoing unnecessary extensive surgical procedures. We hope to heighten awareness of this diagnosis, thereby increasing the index of suspicion and minimizing errors in diagnosis.

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Section: Discussioncontrasting

confidence: 51%

Pulmonary sclerosing hemangioma: pitfalls in management

Low

Teo

Eng

et al. 2011

Asian Cardiovasc Thorac Ann

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“…With technical improvements and a better understanding of frozen artefacts, the impact of the artefacts can be reduced. Furthermore, in the case of uncertainty, it is recommended to seek consultation from colleagues, request more tissue samples or defer the diagnosis …”

Section: Discussionmentioning

confidence: 99%

Pulmonary sclerosing pneumocytoma remains a diagnostic challenge using frozen sections: a clinicopathological analysis of 59 cases

Yang

Lee

2017

Histopathology

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“…In frozen section, it is possible that pathologists can diagnose SP in the majority of cases with available clinical information. However, pathologists should pay attention to intraoperatively diagnose in some atypical cases …”

Section: Discussionmentioning

confidence: 99%

Imprint cytologic and immunocytochemical findings of sclerosing pneumocytoma

Ohara

Mizuno

Yorita

2016

Diagnostic Cytopathology

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To the best of our knowledge, there is no description on immunocytochemical study of sclerosing pneumocytoma (SP) using a cell transfer method. In this article, we report imprint cytological and immunocytochemical findings of SP. Three cases of SP possessing both imprint cytological and histological materials were examined. All tumors showed well-defined margin grossly. On microscopic examination, the tumor consisted of surface and stromal round cells. Cytologically, surface and stromal round cells showed fragments or clusters of papillary configuration with low N/C ratio and cell clusters of small to medium-sized cells with high N/C ration. Immunocytochemically, surface cells showed the positive reaction for surfactant apoprotein A (SPA), but stromal round cell exhibited the negative reaction for SPA. Cytologists and pathologists should steadily recognize cytological findings of surface and stromal round cells of SP. Immunocytochemistry of SPA may be useful in the discrimination of both cells. Diagn. Cytopathol. 2017;45:274-278. © 2016 Wiley Periodicals, Inc.

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Can pulmonary sclerosing haemangioma be accurately diagnosed by intra‐operative frozen section?

Cited by 30 publications

References 19 publications

Pulmonary sclerosing hemangioma: pitfalls in management

Pulmonary sclerosing hemangioma: pitfalls in management

Pulmonary sclerosing pneumocytoma remains a diagnostic challenge using frozen sections: a clinicopathological analysis of 59 cases

Imprint cytologic and immunocytochemical findings of sclerosing pneumocytoma

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