Can proteomics‐based diagnostics aid clinical psychiatry?

Abstract

Despite major advances in infrastructure and instrumentation, proteomics-driven translational applications have not yet yielded the results that the scientific community has envisaged. In this viewpoint, the perspective of proteomics-based diagnostics in the field of clinical psychiatry is explored. The challenges that proteomics faces in the context of translational approaches are outlined and directions toward a successful clinical implementation are provided. Additional challenges that psychiatric disorders pose for clinical proteomics are highlighted and the potential of proteomics-based, blood tests for psychiatric disorders is being assessed. Proteomics offers a valuable toolkit for clinical translation that needs to be handled in a pragmatic manner and with realistic expectations.

Unraveling the Serum Metabolomic Profile of Post-partum Depression

“…The aim of this work was to identify molecular signatures for PPD by comparing the serum metabolomic profiles of women with PPD vs. control subjects. Multi-omics approaches have the potential to shed light on molecular mechanisms of psychiatric disorders in a high-throughput and data-driven manner (Filiou, 2015). Metabolomic analyses provide valuable information for dissecting neuropsychiatric conditions, as the metabolome correlates directly with the phenotype and is very sensitive to environmental stressors and changes (Quinones and Kaddurah-Daouk, 2009; Turck and Filiou, 2015).…”