Can preoperative gonadotropin and testosterone levels predict the success of varicocelectomy?

Ok, Fesih; Erdoğan, Ömer; Durmuş, Emrullah

doi:10.1111/and.13887

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…The total sperm count and the ratio of the progressively motile was used to determine total progressively motile sperm count (TPMSC = total sperm number (10 6 /ejaculate) × progressive motility (PR, %); PR, progressive (a + b motility)] [ 15 ]. In post-operative semen analysis, we defined semen parameter improvement as a greater than 50% increase in total motile sperm count (TMSC) within six months of surgery [ 15 ]. Semen analysis was conducted repeatedly and assessed in accordance with WHO guidelines [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

Nomogram for Predicting Semen Parameters Improvement after Microscopic Varicocelectomy in Infertile Men with Abnormal Semen Parameters

Liu

Pan

et al. 2022

JPM

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Objectives: Information on the prediction of improved semen parameters following varicocelectomy is scarce and mostly contradictory. Therefore, we developed and validated a nomogram to predict whether abnormal semen parameters in infertile men could improve following microscopic varicocelectomy (MSV). Methods: From January 2018 to December 2021, 460 consecutive patients who underwent MSV were included. Of them, 336 patients as a development cohort at the Xiang Hua institution. As a validation cohort, Hu Nan Center (124 patients) was used. Clinicopathologic patient information was recorded. The likelihood ratio test using Akaike’s information criteria was employed as the stopping rule, and multivariate logistic regression was utilized to create a prediction model with regression coefficients. The effectiveness of this prediction model was evaluated based on its ability of discrimination, calibration, and clinical utility. Results: The initial total progressively motile sperm count (TPMSC) and vein diameter were predictors of this model. The model demonstrated strong discrimination for the validation cohort, with an area under the receiver operating characteristic (AUROC) of 0.925 (p < 0.001), and strong calibration (unreliability test, p = 0.522). The decision curve study proved the model’s clinical applicability. Conclusion: According to our research, the improvement of semen parameters in infertile men following MSV was significantly predicted by greater vein diameter and higher initial TPMSC. This nomogram aids in individualized decision-making on the varicocele preoperative treatment plan and may help to enhance the therapeutic result.

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Section: Methodsmentioning

confidence: 99%

Nomogram for Predicting Semen Parameters Improvement after Microscopic Varicocelectomy in Infertile Men with Abnormal Semen Parameters

Liu

Pan

et al. 2022

JPM

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“…In COVID-19 patients with severe inflammation, there is an increase in the inflammatory response and a decrease in the immune response. These responses are shown in the blood test results, including the leukocyte count, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) (Ok et al 2021. Vaccination is necessary for COVID-19 management to reduce the number of COVID-19 cases.…”

Section: Introductionmentioning

confidence: 99%

COVID-19 Disease Severity and Blood Test Results in Unvaccinated and Vaccinated Patients at Bhayangkara Hospital, Denpasar, Indonesia

Chanif Lutfiyati Muyasaroh,

Ngurah Intan Wiratmini,

Anak Agung Sagung Alit Sukmaningsih

2023

FMI

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Highlights: This original research report on the differences in disease severity and blood test results between unvaccinated and vaccinated COVID-19 patients is quite novel, as the COVID-19 pandemic was still happening when this study was carried out. This original research report offers information on the advantages of the COVID-19 vaccines and provides data that the public may use as scientific evidence to counter hoaxes. Abstract The COVID-19 pandemic caused by SARS-CoV-2 is an unprecedented event in human history. Vaccines are a safe, long-term solution for addressing the COVID-19 pandemic. This study aimed to investigate the differences in disease severity and blood test results between unvaccinated and vaccinated COVID-19 patients. This study used an analytical observational method with purposive sampling. A total of 90 COVID-19 patients at Bhayangkara Hospital, Denpasar, Indonesia, were divided into three groups: unvaccinated group (V0), two-dose vaccinated group (Vp), and three-dose vaccinated group (Vb). Primary data were collected from July to December 2022, while secondary data were collected from January 2021 to June 2022. The data were analyzed using the Kruskal-Wallis test followed by the Mann-Whitney test, as well as one-way ANOVA test followed by Tukey's honestly significant difference (HSD) test with a confidence interval (CI) of 95% and α of 5%. The results revealed significant differences in disease severity (p<0.001). V0 had a higher percentage of severe (36.7%) and critical (6.7%) symptoms than Vp (severe=10.0%; critical, n=0) and Vb (severe and critical, n=0). The follow-up tests revealed significant differences in disease severity between V0 and Vp (p<0.001), V0 and Vb (p<0.001), as well as Vp and Vb (p=0.001). Blood test results revealed significant differences in lymphocytes (p=0.005), monocytes (p<0.001), monocyte-to-lymphocyte ratio (MLR) (p<0.001), and eosinophils (p=0.037). The follow-up tests revealed significant differences in these four indicators between V0 and Vb, in all parameters except for lymphocytes between V0 and Vp, and in lymphocytes only between Vp vs Vb. In conclusion, unvaccinated patients had a higher percentage of severe and critical symptoms than vaccinated patients. The blood test results revealed significant differences in lymphocytes, monocytes, MLR, and eosinophils. Unvaccinated patients had lower lymphocyte counts, higher MLR levels, and higher monocyte counts than vaccinated patients.

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“…To date, there have been many studies dedicated to the analysis of factors (predictors) affecting microsurgical varicocelectomy outcomes. 15 – 17 However, most of these studies are of a retrospective and prospective uncontrolled nature, and the results of most of them are conflicting, which do not allow unequivocal conclusions to be drawn. 18 In this review, we tried to collect and systematize all the evidence on the predictors of microsurgical varicocelectomy efficacy in male infertility treatment.…”

Section: Introductionmentioning

confidence: 99%

Predictors of microsurgical varicocelectomy efficacy in male infertility treatment: critical assessment and systematization

Shomarufov

Bozhedomov

Сорокин

et al. 2022

Asian Journal of Andrology

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In this review, we tried to systematize all the evidence (from PubMed [MEDLINE], Scopus, Cochrane Library, EBSCO, Embase, and Google Scholar) from 1993 to 2021 on the predictors of microsurgical varicocelectomy efficacy in male infertility treatment. Regarding the outcomes of varicocele repair, we considered semen improvement and pregnancy and analyzed them separately. Based on the 2011 Oxford CEBM Levels of Evidence, we assigned a score to each trial that studied the role of the predictor. We systematized the studied predictors based on the total points, which were, in turn, calculated based on the number and quality of studies that confirmed or rejected the studied predictor as significant, into three levels of significance: predictors of high, moderate, and low clinical significance. Preoperative total motile sperm count (TMSC) coupled with sperm concentration can be a significant predictor of semen improvement and pregnancy after varicocelectomy. In addition, for semen improvement alone, scrotal Doppler ultrasound (DUS) parameters, sperm DNA fragmentation index (DFI), and bilateral varicocelectomy are reliable predictors of microsurgical varicocelectomy efficacy.

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Can preoperative gonadotropin and testosterone levels predict the success of varicocelectomy?

Cited by 4 publications

References 32 publications

Nomogram for Predicting Semen Parameters Improvement after Microscopic Varicocelectomy in Infertile Men with Abnormal Semen Parameters

Nomogram for Predicting Semen Parameters Improvement after Microscopic Varicocelectomy in Infertile Men with Abnormal Semen Parameters

COVID-19 Disease Severity and Blood Test Results in Unvaccinated and Vaccinated Patients at Bhayangkara Hospital, Denpasar, Indonesia

Predictors of microsurgical varicocelectomy efficacy in male infertility treatment: critical assessment and systematization

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