Can pregnancy rate be improved in gonadotropin-releasing hormone (GnRH) antagonist cycles by administering GnRH agonist before oocyte retrieval? A prospective, randomized study

Schächter, M; Friedler, Shevach; Ron-El, Raphaël; Zimmerman, Ariel L.; Strassburger, D.; Bern, O.; Raziel, Arieh

doi:10.1016/j.fertnstert.2007.07.1316

Cited by 84 publications

(89 citation statements)

References 23 publications

(25 reference statements)

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“…While, the number of oocytes collected were similar in both arms, a significantly higher proportion of them were mature (70%vs 57%, p = 0.04), and fertilization rate were significantly higher (63%vs 55%, p = 0.01) in the FSH dual-trigger group. Similar to Schachter et al [34] study, the increment in ongoing pregnancy or live birth rates with co-trigger was short of statistical significance (52%vs 44%, p = 0.3). When the results are pooled the beneficial effect of FSH surge is at the verge of significance (Figure 2).…”

supporting

confidence: 77%

“…Griffin et al [33] retrospectively reported significantly increased live birth rates with dual trigger despite similar numbers of oocytes being collected following hCG alone. In a RCT involving 211 patients stimulated with a GnRH ant protocol, Schachter et al [34] reported similar number of oocytes collected and fertilization rate with dual trigger and hCG trigger. However, despite clinically significant trends in implantation (17%vs 21%, p = 0.34) and ongoing pregnancy rates (22%vs 36%, p = 0.07) favoring dual trigger, differences were short of statistical significance.…”

mentioning

confidence: 93%

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A Brief History of GnRH Agonist Trigger and Directions for Future Research

2014

JFIV Reprod Med Genet

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supporting

confidence: 77%

mentioning

confidence: 93%

A Brief History of GnRH Agonist Trigger and Directions for Future Research

2014

JFIV Reprod Med Genet

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“…1) illustrating the mechanisms of exclusion for certain studies in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement [20]. The search strategy retrieved 326 potentially eligible studies and subsequently excluded 321 studies with the following reasons: 308 were not relevant to the contents we interested; two were cohort studies and 1 used casecontrol design; five were with different experiment designs [21][22][23][24][25], the time interval referred to hCG-to-intrauterine insemination (IUI) or hMG-to-hCG rather than hCG-tooocyte retrieval; three were missing test group or control group [12,26,27]; one was missing available outcome data [10]; one was duplicate publication [17]. Finally, 5 RCTs [13,16,17,28,29] totaling 895 participants were included in this meta-analysis.…”

Section: Literature Search Resultsmentioning

confidence: 99%

The time interval between hCG priming and oocyte retrieval in ART program: a meta-analysis

Wang

Zhang

Wang

et al. 2011

J Assist Reprod Genet

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Objective To evaluate the relationship between different hCG priming-to-oocyte retrieval intervals and assisted reproductive technology (ART) outcome. Methods We systematically searched PubMed, EMBASE, the Cochrane Library, Science Citation Index, Chinese biomedicine (CBM) literature database, and Chinese Journal Full-text Database for randomized controlled trials (RCTs) published up to November 2010. Data was extracted from the studies by two independent reviewers. Statistical analysis was performed with Cochrane Collaboration's Review Manager (RevMan) 5.0.2. From extracted data, Risk Ratio (RR) with 95% confidence interval (CI) was calculated. Results 5 RCTs totaling 895 participants were included. Oocyte maturation rate was higher in the long interval group compared with short interval group (RR, 0.67; 95% CI, 0.62-0.73). There were no significant difference between the two groups with regard to fertilization rate (RR, 0.99; 95% CI, 0.94-1.04), implantation rate (RR, 0.91; 95% CI, 0.40-2.04), and pregnancy rate (RR, 0.79; 95% CI, 0.58-1.08). Conclusion The percentage of mature (MII) oocytes can be increased by prolonging the interval between hCG priming and oocyte retrieval. The prolonged interval could not increase the fertilization rate, implantation rate, and pregnancy rate. Although there was evidence to confirm the results, they still need to be confirmed by large-sample, multicenter, randomized controlled trials. The time interval dependent mechanisms responsible for ART performance need to be elucidated.

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“…The GnRH antagonist cetrorelix (Cetrotide; MerckKGaA) was used for pituitary suppression and was initiated on stimulation day 5 or 6. Final oocyte maturation was induced with 250 mcg of recombinant hCG (Ovitrelle®; MerckKGaA) plus 0.2 mg of triptorelin (Gonapeptyl daily®; Ferring Pharmaceuticals, Saint Prex, Switzerland), referred to as a Bdual trigger [ 9], when at least two follicles reached a diameter of 18 mm. The patients underwent transvaginal ultrasound-guided oocyte retrieval at 35 h after trigger, followed by intracytoplasmic sperm injection (ICSI).…”

Section: Study Protocolmentioning

confidence: 99%

Ratio of progesterone-to-number of follicles as a prognostic tool for in vitro fertilization cycles

Roque

Valle

Sampaio

et al. 2015

J Assist Reprod Genet

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Purpose To establish a ratio of the P level to the number of follicles (P/F ratio) on the day of human chorionic gonadotropin (hCG) administration and to evaluate whether this ratio is associated with in vitro fertilization (IVF) outcome. Methods This study was conducted between January 2012 and June 2013. A total of 337 patients with cleavage-stage day-3 fresh embryo transfer with P levels ≤1.5 ng/mL on the day of hCG administration were included in the study. The main outcome was ongoing pregnancy rate. Result(s) The P/F ratio was calculated according to the equation (P[ng/mL]/number of follicles) on the day of final oocyte maturation. Using ROC, we established a cut-off level of 0.075 for the P/F ratio. The area under the curve (AUC) (0.756; 95 % confidence interval [CI]: 0.704-0.807) indicated that it was a good prognostic test. In group 1 (patients under 36 years old), the ongoing pregnancy rates were 57 and 30 % for patients with P/F ratios≤.075 and>.075, respectively, (p= 0.003). In group 2 (patients between 36 and 39 years old), the ongoing pregnancy rates were 58 % and 17 % (p=0.001) for patients with P/F ratios ≤.075 and>.075, respectively. In group 3 (patients≥40 years old), the ongoing pregnancy rates were 41.7 and 10.9 % (p=0.001) for patients with P/F ratios≤.075 and>.075, respectively. Conclusions The P/F ratio is a good prognostic test for predicting IVF outcome that can correlate the P level with ovarian response.

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Can pregnancy rate be improved in gonadotropin-releasing hormone (GnRH) antagonist cycles by administering GnRH agonist before oocyte retrieval? A prospective, randomized study

Cited by 84 publications

References 23 publications

A Brief History of GnRH Agonist Trigger and Directions for Future Research

A Brief History of GnRH Agonist Trigger and Directions for Future Research

The time interval between hCG priming and oocyte retrieval in ART program: a meta-analysis

Ratio of progesterone-to-number of follicles as a prognostic tool for in vitro fertilization cycles

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