Can pleural adenosine deaminase (ADA) levels in pleural tuberculosis predict the presence of pulmonary tuberculosis? A CT analysis

Koh, Myung Je; Lee, In Jae; Kim, Joohee

doi:10.1016/j.crad.2016.02.011

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…Although indication for thoracoscopy should be further investigated, we expect that our strategy is feasible in real clinical practice. In addition, Koh et al have reported that TPE patients with pulmonary involvement shows higher ADA level than those without 40 . Based on this finding, we expect that the bias resulting from exclusion of many TPE cases with pulmonary involvement would be little.…”

Section: Discussionmentioning

confidence: 99%

Investigating the appropriate adenosine deaminase cutoff value for the diagnosis of tuberculous pleural effusion in a country with decreasing TB burden

Kim

Shin

et al. 2022

Sci Rep

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As the burden of tuberculosis (TB) in South Korea decreases while that of malignancy increases with an aging society, the composition of etiology for pleural effusion is changing. The aim of this study was to investigate the diagnostic value of adenosine deaminase (ADA) for diagnosis of tuberculous pleural effusion (TPE) in this circumstance. Medical records of patients who underwent medical thoracoscopy from May 2015 to September 2020 in Incheon St. Mary Hospital, Korea were retrospectively reviewed. TPE was diagnosed if one of the following criteria was met: (1) granuloma in pleura, (2) positive TB polymerase chain reaction or culture in pleural fluid or tissue with non-specific pathologic findings in pleura, or (3) bacteriologically confirmed pulmonary TB with non-specific pathologic findings in pleura. A total of 292 patients, including 156 with malignant pleural effusion (MPE), 52 with TPE, and 84 with other benign effusion, were analyzed. Among 206 patients with lymphocyte dominant pleural effusion, the area under receiver characteristic curve of ADA for diagnosis of TPE was 0.971. The sensitivity and specificity of a current cutoff value of 40 IU/L were 1.00 and 0.61, respectively, whereas those of a raised cutoff value of 70 IU/L were 0.93 and 0.93, respectively. Among 54 patients with ADA levels of 40–70 IU/L, 30 (55.6%) patients were diagnosed as MPE, 21 (38.9%) as other benign effusion, and only 3 (5.6%) as TPE. Caution is needed in clinical diagnosis of TPE with current ADA cutoff value in countries with decreasing TB incidence, due to many false positive cases.

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Section: Discussionmentioning

confidence: 99%

Investigating the appropriate adenosine deaminase cutoff value for the diagnosis of tuberculous pleural effusion in a country with decreasing TB burden

Kim

Shin

et al. 2022

Sci Rep

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“…Thus, increased pulmonary ADA activity on exposure to aerosolized petroleum hydrocarbons is a consequential effect of the removal of lung's extracellular adenosine [63]. The depleted adenosine impaired adenosinergic signal transduction of the bronchi and alveoli by accumulating alveoli monocytes and macrophages during exposure to aerosols of fractionated petroleum hydrocarbons [66]. Some studies had reported that patients suffering from Chronic Obstructive Pulmonary Disease (COPD), squamous carcinoma, contagious pleuroparenchymal tuberculosis, and bronchopneumonia had uncontrollable production of ADA activity [67e69].…”

Section: Discussionmentioning

confidence: 99%

Diet from Mantisa religiosa-egg case abolishes pulmonary dysfunctions triggered by sub-acute exposure to aerosolized-petroleum hydrocarbons in rat model

Akintunde

Obisesan

Akinsete

et al. 2019

Clinical Nutrition Experimental

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Can pleural adenosine deaminase (ADA) levels in pleural tuberculosis predict the presence of pulmonary tuberculosis? A CT analysis

Cited by 2 publications

References 17 publications

Investigating the appropriate adenosine deaminase cutoff value for the diagnosis of tuberculous pleural effusion in a country with decreasing TB burden

Investigating the appropriate adenosine deaminase cutoff value for the diagnosis of tuberculous pleural effusion in a country with decreasing TB burden

Diet from Mantisa religiosa-egg case abolishes pulmonary dysfunctions triggered by sub-acute exposure to aerosolized-petroleum hydrocarbons in rat model

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