2011
DOI: 10.1258/ijsa.2011.010464
|View full text |Cite
|
Sign up to set email alerts
|

Can plasma HHV8 viral load be used to differentiate multicentric Castleman disease from Kaposi sarcoma?

Abstract: We measured plasma human herpesvirus 8 (HHV8) DNA load in consecutive patients presenting with HIV-associated multicentric Castleman disease (MCD) and in contemporaneous patients who had Kaposi sarcoma (KS), lymphoma or other diagnoses. All 11 patients with MCD had detectable plasma HHV8 DNA compared with 18 (72%) of 25 patients with KS, none with lymphoma and one of 38 patients with other diagnoses. Detectable plasma HHV8 DNA levels were higher among MCD patients, median (interquartile range [IQR]) = 43,500 (… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

2
13
1

Year Published

2012
2012
2021
2021

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 15 publications
(16 citation statements)
references
References 30 publications
(46 reference statements)
2
13
1
Order By: Relevance
“…This study has explored the role of plasma KSHV as a tumour marker in KSHV‐associated diseases. The use of plasma KSHV as a diagnostic marker in PLWH appears to be limited and this larger study contradicts previous reports that suggested that the KSHV viral load was able to differentiate between the three main KSHV‐associated pathologies [5–7]. These earlier publications suggested that the highest KSHV viral levels were detected in those with KSHV‐associated lymphomas, then in those with MCD, and the lowest levels were found in those with KS.…”
Section: Discussioncontrasting
confidence: 94%
See 1 more Smart Citation
“…This study has explored the role of plasma KSHV as a tumour marker in KSHV‐associated diseases. The use of plasma KSHV as a diagnostic marker in PLWH appears to be limited and this larger study contradicts previous reports that suggested that the KSHV viral load was able to differentiate between the three main KSHV‐associated pathologies [5–7]. These earlier publications suggested that the highest KSHV viral levels were detected in those with KSHV‐associated lymphomas, then in those with MCD, and the lowest levels were found in those with KS.…”
Section: Discussioncontrasting
confidence: 94%
“…As a diagnostic biomarker, it has been postulated that the KSHV viral load is able to differentiate between different KSHV‐associated pathologies, with the highest levels in KSHV‐associated lymphomas, then in MCD, and the lowest levels in KS [5–7]. Numerous published studies have shown that KSHV is almost always detectable in the blood of patients with active MCD and that levels of KSHV DNA correlate with symptomatic disease [8–14].…”
Section: Introductionmentioning
confidence: 99%
“…This represents the highest KSHV viral load on record (Table 1). By comparison KS patients (Polstra et al, 2003, Sayer et al, 2011) typically have a mean KSHV viral load of 1000 copies / ml (range 151 – 26,915), PEL patients (Simonelli et al, 2009) of 10,284 copies / ml (range 2,558 – 36,300) and MCD (Simonelli et al, 2009) of 4,400 copies / ml (range 600 – 1,678,000). KS malignancies are AIDS defining, but rarely associated with high-level virus replication.…”
Section: Resultsmentioning
confidence: 99%
“…At present, it is generally believed that interleukin‐6 (IL‐6) produced by the lymph nodes plays a very important role in the occurrence and development of CD . Several studies reported that the occurrence of MCD in adults was closely related to HHV8 infection in AIDS patients , but controversy exists between MCD and HHV8 in patients without HIV infection . Recently, Sandrine Leroy et al found that MCD was closely related to HHV8 infection in a meta‐analysis of 32 children with a history of MCD.…”
Section: Discussionmentioning
confidence: 99%
“…Pediatr Blood Cancer DOI 10.1002/pbc Several studies reported that the occurrence of MCD in adults was closely related to HHV8 infection in AIDS patients [11,12], but controversy exists between MCD and HHV8 in patients without HIV infection [13]. Recently, Sandrine Leroy et al [14] found that MCD was closely related to HHV8 infection in a meta-analysis of 32 children with a history of MCD.…”
Section: Discussionmentioning
confidence: 99%