Can placental growth factor in maternal circulation identify fetuses with placental intrauterine growth restriction?

Benton, Samantha J.; Hu, Yuxiang; Xie, Fang; Küpfer, K.; Lee, Seok-Won; Magee, Laura A.; Dadelszen, Peter von

doi:10.1016/j.ajog.2011.09.019

Cited by 103 publications

(60 citation statements)

References 31 publications

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“…It is not clear why FGR, secondary to poor placentation, 153,155 can yield similar changes in circulating proangiogenic and antiangiogenic factors without stimulating maternal hypertension and proteinuria. This again emphasizes the interaction of fetal and maternal factors, and the likelihood that a more appropriate interpretation is the predominance of maternal or preponderance of placental features in preeclampsia, rather than dichotomy of these factors in the genesis of preeclampsia.…”

Section: Extending the Definition And Diagnosis Of Preeclampsia Usingmentioning

confidence: 99%

“…38,133,154 When placental pathology is used to define an FGR outcome, a stronger association with lower circulating PlGF is observed. 153 These findings lead us to postulate that low maternal circulating PlGF concentration reflects placental dysfunction resulting in clinical manifestations of preeclampsia and FGR.…”

Section: Does Low Circulating Plgf In Preeclampsia Reflect Abnormal Pmentioning

confidence: 99%

“…38 Most interestingly, low-PlGF concentrations are also observed in the circulation of women with growth restricted fetuses without preeclampsia. 38,133,153 Smallness for gestational age can be used as a crude proxy to assign FGR outcomes, which will include pregnancies complicated by poor placentation. Hence, studies have found women who deliver a small for gestational age infant more likely to have lower circulating PlGF concentrations.…”

Section: Does Low Circulating Plgf In Preeclampsia Reflect Abnormal Pmentioning

confidence: 99%

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Redefining Preeclampsia Using Placenta-Derived Biomarkers

et al. 2013

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Section: Extending the Definition And Diagnosis Of Preeclampsia Usingmentioning

confidence: 99%

Section: Does Low Circulating Plgf In Preeclampsia Reflect Abnormal Pmentioning

confidence: 99%

Section: Does Low Circulating Plgf In Preeclampsia Reflect Abnormal Pmentioning

confidence: 99%

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Redefining Preeclampsia Using Placenta-Derived Biomarkers

et al. 2013

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“…Recent studies [62,63] suggest that differences in maternal PlGF concentrations may have the ability to discriminate between fetuses with placental IUGR and constitutionally small fetuses. Placental vascular insufficiency in late pregnancy may be anticipated by maternal low detectable PlGF levels on discovery of SGA status.…”

Section: Prediction Of Complications Of Placental Diseasementioning

confidence: 99%

Update on the Pathophysiological Implications and Clinical Role of Angiogenic Factors in Pregnancy

2015

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Angiogenic markers are now being incorporated into clinical practice for the screening, diagnosing, and monitoring of preeclampsia. Pregnancy requires both vasculogenesis and angiogenesis in the fetal compartment and angiogenesis in the maternal compartment. Abnormal angiogenesis in the placenta determines impaired remodeling of the maternal spiral arteries and placental underperfusion that may ultimately lead to fetal growth restriction and maternal preeclampsia. The dysregulation of angiogenesis in the placenta and maternal-fetal circulation has emerged as one of the main pathophysiological features in the development of placental insufficiency and its clinical consequences. Abnormal angiogenesis has also been related to other obstetric and fetal conditions such as peripartum cardiomyopathy and fetal cardiac defects. This opens up new challenges for our understanding of angiogenic involvement in maternal cardiovascular function and fetal cardiac development, and it offers new clinical opportunities. This review summarizes the current knowledge of the pathophysiological implications and the clinical role of angiogenic factors in pregnancy.

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“…자간전증 환자의 경우, 같은 임신주수의 임신부와 비교했을 때 PlGF 수치가 비정상적으로 낮고, PlGF 수치는 약한 자간전증에서보 다 심각한 자간전증에서 더 낮은 것으로 알려져 있다 [7]. 또한, 다른 연 구에서는 저체중아를 분만한 산모에게서 역시 낮은 PlGF 수치를 나타 냈다고 보고했다 [7,8]. 그러나 이러한 PlGF를 이용한 스크리닝검사는 널리 임상적으로 이용되기에 정확하게 입증되지 않았다.…”

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The association of serum placental growth factor with pregnancies complicated by preeclampsia and small for gestational age

Lee

Yang

Park

et al. 2012

Korean J Obstet Gynecol

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ObjectivePlacental growth factor (PlGF) is one of the many angiogenic factors, which is decreased in placenta and serum during preeclampsia (PE) and also associated with pregnancies complicated by small for gestational age. In this study, we compared serum PlGF levels with different groups (controls, PE patients, pregnant women with small for gestational age [SGA]) and evaluated the usefulness of PlGF for diagnosis. MethodsSerum samples were collected at the time of delivery from 40 women with uncomplicated pregnancies, 30 women with PE, 30 women with pregnancies complicated by SGA fetuses. Serum PlGF level was measured in all the samples using Triage PlGF test. We used the Kruskal-Wallis test and receiver operator characteristic curve analysis. ResultsMaternal serum PlGF concentrations in pregnancies complicated by PE (21.17 ±15.27 pg/mL) were significantly lower than those in uncomplicated pregnancies (133.70 ±158.80 pg/mL, P<0.01) and PlGF concentrations were decreased in pregnancies complicated by SGA fetuses (95.65 ± 210.36 pg/mL) compared with control group, but there was no statistically significant difference. ConclusionDecreased PlGF concentrations were observed in pregnancies complicated by PE and SGA. PlGF concentrations in pregnancies complicated by PE was significantly lower than those in uncomplicated pregnancies. By further prospective investigation, we may expect that the PlGF levels during pregnancy will be a marker to identify women at risk for the development of PE and SGA.

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Can placental growth factor in maternal circulation identify fetuses with placental intrauterine growth restriction?

Cited by 103 publications

References 31 publications

Redefining Preeclampsia Using Placenta-Derived Biomarkers

Redefining Preeclampsia Using Placenta-Derived Biomarkers

Update on the Pathophysiological Implications and Clinical Role of Angiogenic Factors in Pregnancy

The association of serum placental growth factor with pregnancies complicated by preeclampsia and small for gestational age

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