Can photobiomodulation therapy (LASER/LED) associated or not with biomaterials accelerate the process of bone repair the lower limbs of rats? A systematic review study

Abstract

Many studies have investigated the use of synthetic biomaterials or the use of PBMT to improve the bone repair process. However, there is little evidence on the use of these associated techniques. In view of the above, the present study aimed to carry out a systematic review on the effects of the association of photobiomodulation by low-intensity laser and/or diode-emitting light to biomaterials on bone repair. The present study was conducted according to the Preferred Reporting Items for Meta-Analysis (PRISMA) guidelines, as well as using the terms pre-established by the Cochrane Library Collaboration. Electronic searches were performed in the following databases: PubMed/MEDLINE and Science Direct. The search terms used were "bone repair"; "low-level laser therapy"; "photobiomodulation"; "light emitting diode"; "biomaterials"; "bone substitutes"; "in vivo animal studies". SYRCLE (SYStematic Review Center for Laboratory animal Experimentation) was used to analyze the bias of the studies. A total of 506 studies were found based on the descriptors used, 297 were found in PubMed/MedLine and 209 in Science Direct. Analysis of abstracts and methodology of 108 studies was performed and 86 were excluded. Only 22 studies were considered eligible. At the end of this review, it can be verified that the data presented in recent literature show potential to improve the process of bone repair using PBMT together with several types of biomaterials.