Can PET hypoxia tracers predict radioresistance?

Chia, Kazumi; Weeks, Amanda; Paul, Rowena L.; Cleij, Marcel; Blower, Philip J.

doi:10.1016/j.nucmedbio.2010.04.109

Cited by 2 publications

(1 citation statement)

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“…20 mm Hg is the threshold below which cellular radiosensitivity begins to drop substantially). This extremely low threshold suggests that only a very small subset of cells in a hypoxic region of tumor will be hypoxic enough to trap the tracer, and consequently the uptake will be much lower than optimal leading to images with limited clinical usefulness (109).…”

Section: Copper: Exploiting Redox Chemistrymentioning

confidence: 99%

Opportunities and Challenges for Metal Chemistry in Molecular Imaging

Southworth

Rosales

Meszaros

et al. 2016

Advances in Inorganic Chemistry

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The development of medical imaging is a highly multidisciplinary endeavor requiring the close cooperation of clinicians, physicists, engineers, biologists and chemists to identify capabilities, conceive challenges and solutions and apply them in the clinic. The chemistry described in this article illustrates how synergistic advances in these areas drive the technology and its applications forward, with each discipline producing innovations that in turn drive innovations in the others. The main thread running through the article is the shift from single photon radionuclide imaging towards PET, and in turn the emerging shift from PET/CT towards PET/MRI and further, combination of these with optical imaging. Chemistry to support these transitions is exemplified by building on a summary of the status quo, and recent developments, in technetium-99m chemistry for SPECT imaging, followed by a report of recent developments to support clinical application of short lived (Ga-68) and long-lived (Zr-89) positron emitting isotopes, copper isotopes for PET imaging, and combined modality imaging agents based on radiolabelled iron oxide based nanoparticles.

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Section: Copper: Exploiting Redox Chemistrymentioning

confidence: 99%

Opportunities and Challenges for Metal Chemistry in Molecular Imaging

Southworth

Rosales

Meszaros

et al. 2016

Advances in Inorganic Chemistry

Self Cite

View full text Add to dashboard Cite

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Molecular imaging of hypoxia in non-small-cell lung cancer

Yip

Blower

Goh

et al. 2015

Eur J Nucl Med Mol Imaging

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Non-small-cell lung cancer (NSCLC) is the commonest cancer worldwide but survival remains poor with a high risk of relapse, particularly after nonsurgical treatment. Hypoxia is present in a variety of solid tumours, including NSCLC. It is associated with treatment resistance and a poor prognosis, although when recognised may be amenable to different treatment strategies. Thus, noninvasive assessment of intratumoral hypoxia could be used to stratify patients for modification of subsequent treatment to improve tumour control. Molecular imaging approaches targeting hypoxic cells have shown some early success in the clinical setting. This review evaluates the evidence for hypoxia imaging using PET in NSCLC and explores its potential clinical utility.

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Can PET hypoxia tracers predict radioresistance?

Cited by 2 publications

References 0 publications

Opportunities and Challenges for Metal Chemistry in Molecular Imaging

Opportunities and Challenges for Metal Chemistry in Molecular Imaging

Molecular imaging of hypoxia in non-small-cell lung cancer

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