Can Periodontal Disease Lead to Premature Delivery?

Wener, Mickey Emmons; Lavigne, Salme E

doi:10.1177/1091592304271624

Cited by 7 publications

(12 citation statements)

References 9 publications

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“…9 As early as puberty, the hormones estrogen and progesterone exaggerate the mechanism of gum tissue reaction to irritants in plaque, making women easy targets for PD. 9 As early as puberty, the hormones estrogen and progesterone exaggerate the mechanism of gum tissue reaction to irritants in plaque, making women easy targets for PD.…”

Section: Periodontal Disease In Womenmentioning

confidence: 99%

“…9,[12][13][14][15] The discomforts of periodonatal disease may interfere with maternal nutritional intake. 9,[12][13][14][15] The discomforts of periodonatal disease may interfere with maternal nutritional intake.…”

Section: Periodontal Disease and Its Impact On Maternal And Infant Hementioning

confidence: 99%

“…14,16,17 This bacterial challenge results in increased cytokine expression, which can impact placental function and precipitate preterm labor. 9,20 In addition, periodontitis is associated with elevated prostaglandin E 2 that is capable of inducing uterine contractions. 9,20 In addition, periodontitis is associated with elevated prostaglandin E 2 that is capable of inducing uterine contractions.…”

Section: Periodontal Disease and Its Impact On Maternal And Infant Hementioning

confidence: 99%

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Periodontal Disease in Pregnancy

Lachat

Solnik

Nana

et al. 2011

Journal of Perinatal &Amp; Neonatal Nursing

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Section: Periodontal Disease In Womenmentioning

confidence: 99%

Section: Periodontal Disease and Its Impact On Maternal And Infant Hementioning

confidence: 99%

Section: Periodontal Disease and Its Impact On Maternal And Infant Hementioning

confidence: 99%

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Periodontal Disease in Pregnancy

Lachat

Solnik

Nana

et al. 2011

Journal of Perinatal &Amp; Neonatal Nursing

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“…Whereas certain risk factors associated with preterm birth and low birth weight are non-modifiable factors (e.g., higher incidence of multiple births and advanced maternal age (Health Canada)), others can be controlled. Case in point, approximately 50% of preterm births occur without a known cause, of which up to half may be attributed to maternal bacterial infections [8]. …”

Section: Introductionmentioning

confidence: 99%

“…The bacteria in the placenta and amniotic fluid trigger an inflammatory response, which can, under appropriate conditions that require the release of prostaglandins, induce preterm labor, or, in early pregnancy, miscarriage. Copious evidence now demonstrates that normal induction of labor occurs when the fetus has reached complete gestation, but with maternal periodontitis during pregnancy, prostaglandin release significantly increases the risk of preterm labor [8]. Furthermore, periodontitis, as a low-grade chronic infection, may also be blunt growth of the fetus, and lead to low birth weight [8].…”

Section: Introductionmentioning

confidence: 99%

Proteomic signature of periodontal disease in pregnancy: Predictive validity for adverse outcomes

Ramchandani¹,

Siddiqui²,

Kanwar³

et al. 2011

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The rate of preterm birth is a public health concern worldwide because it is increasing and efforts to prevent it have failed. We report a Clinically Relevant Complex Systematic Review (CSCSR) designed to identify and evaluate the best available evidence in support of the association between periodontal status in women and pregnancy outcome of preterm low birth weight. We hypothesize that the traditional limits of research synthesis must be expanded to incorporate a translational component. As a proof-of-concept model, we propose that this CSCSR can yield greater validity of efficacy and effectiveness through supplementing its recommendations with data of the proteomic signature of periodontal disease in pregnancy, which can contribute to addressing specifically the predictive validity for adverse outcomes. For this CRCSR, systematic reviews were identified through The National Library of MedicinePubmed, The Cochrane library, CINAHL, Google Scholar, Web of Science, and the American Dental Association web library. Independent reviewers quantified the relevance and quality of this literature with R-AMSTAR. Homogeneity and inter-rater reliability testing were supplemented with acceptable sampling analysis. Research synthesis outcomes were analyzed qualitatively toward a Bayesian inference, and converge to demonstrate a definite association between maternal periodontal disease and pregnancy outcome. This CRCSR limits heterogeneity in terms of periodontal disease, outcome measure, selection bias, uncontrolled confounders and effect modifiers. Taken together, the translational CRCSR model we propose suggests that further research is advocated to explore the fundamental mechanisms underlying this association, from a molecular and proteomic perspective.

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