Can peptides be orally-delivered in crustaceans? The case study of the Crustacean Hyperglycaemic Hormone in Procambarus clarkii

Manfrin, Chiara; Piazza, Federica; Cocchietto, Moreno; Antcheva, Nikolinka; Masiello, Domenico; Franceschin, Andrea; Peruzza, Luca; Bonzi, Lucrezia C.; Mosco, Alessandro; Guarnaccia, Corrado; Sava, Gianni; Giulianini, Piero Giulio

doi:10.1016/j.aquaculture.2016.05.044

Cited by 8 publications

(4 citation statements)

References 37 publications

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“…It has been shown that the "knock down" of two crustacean hyperglycaemic hormones could affect the survival of P. clarkii in autocidal-based methods [130]. Furthermore, this method is potentially easily applicable year-round through baits and is inexpensive compared to the costs of trapping, the approach used so far to restrict the spread of invasive P. clarkii [131].…”

Section: Silencing Of Key Hormones Through Rna Interference (Rnai)mentioning

confidence: 99%

“…New, user-friendly, cheaper and high-tech autocidal methods are needed for controlling crayfish populations. Among new eradicative methods, a water/oil/water microemulsion is being tested as an autocidal method to convey neuropeptides, which play a role in the control of glycaemia and homeostasis in P. clarkii populations by hampering their physiological state [131]. Oral delivery systems to control invasive crayfish have never been applied in the field up to now, so they represent a new and not entirely investigated management frontier [131].…”

Section: Oral Deliverymentioning

confidence: 99%

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Detection and Control of Invasive Freshwater Crayfish: From Traditional to Innovative Methods

et al. 2019

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Invasive alien species are widespread in freshwater systems compared to terrestrial ecosystems. Among crustaceans, crayfish in particular have been widely introduced and are considered a major threat to freshwater ecosystem functioning. New emerging techniques for detecting and controlling invasive crayfish and protecting endangered native species are; thus, now highly desirable and several are under evaluation. Important innovations have been developed in recent years for detection of both invasive and native crayfish, mainly through eDNA, which allows for the detection of the target species even at low abundance levels and when not directly observable. Forecasting models have also moved towards the creation of realistic invasion scenarios, allowing effective management plans to be developed in advance of invasions. The importance of monitoring the spread and impacts of crayfish and pathogens in developing national data and research networks is emphasised; here “citizen science” can also play a role. Emerging techniques are still being considered in the field of invasive crayfish control. Although for decades the main traditional techniques to manage invasive crayfish were solely based on trapping, since 2010 biological, biocidal, autocidal controls and sexual attractants, monosex populations, RNA interference, the sterile male release technique and oral delivery have all also been investigated for crayfish control. In this review, ongoing methodologies applied to the detection and management of invasive crayfish are discussed, highlighting their benefits and limitations.

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Section: Silencing Of Key Hormones Through Rna Interference (Rnai)mentioning

confidence: 99%

Section: Oral Deliverymentioning

confidence: 99%

Detection and Control of Invasive Freshwater Crayfish: From Traditional to Innovative Methods

et al. 2019

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“…These two genes encode for important metabolic enzymes: the first catalyzes an irreversible step of gluconeogenesis and it is thought to be essential in glucose homeostasis, the second produces Glucose from Glucose-6-phosphate and is essential for control of blood glucose levels (Parker, 2004). The response of many aquatic animals to pollutants and stress is to induce hyperglycaemia (Lorenzon, 2005) and, in crustacean, this has been widely reported to result from exposure to several environmental stressors (Lorenzon et al, 1997;Manfrin et al, 2016). In the light of this it can be hypothesised that the up-regulation of PEPCK and G6Pt could have contributed to attenuate the thermal stress.…”

Section: Discussionmentioning

confidence: 99%

Acclimation to cyclic hypoxia improves thermal tolerance and copper survival in the caridean shrimp Palaemon varians

Peruzza

Thatje

Hauton

2021

Comparative Biochemistry and Physiology Part A: Molecular &

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“…Vaccine-loaded microgels fabricated from a synthetic polymer were shown to be taken up by M-cells and simulate an immune response [154]. Various other kinds of CDSs have also been investigated for their potential of enhancing the efficacy of orally-administered vaccines, including starch microparticles [160], chitosan microparticles [161], hydrophobic polymer particles [162], phospholipid liposomes [157,163], W/O/W emulsions [164,165], and polymer nanoparticles [166].…”

Section: Vaccinesmentioning

confidence: 99%

Recent Advances in Encapsulation, Protection, and Oral Delivery of Bioactive Proteins and Peptides using Colloidal Systems

Perry

McClements

2020

Molecules

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There are many areas in medicine and industry where it would be advantageous to orally deliver bioactive proteins and peptides (BPPs), including ACE inhibitors, antimicrobials, antioxidants, hormones, enzymes, and vaccines. A major challenge in this area is that many BPPs degrade during storage of the product or during passage through the human gut, thereby losing their activity. Moreover, many BPPs have undesirable taste profiles (such as bitterness or astringency), which makes them unpleasant to consume. These challenges can often be overcome by encapsulating them within colloidal particles that protect them from any adverse conditions in their environment, but then release them at the desired site-of-action, which may be inside the gut or body. This article begins with a discussion of BPP characteristics and the hurdles involved in their delivery. It then highlights the characteristics of colloidal particles that can be manipulated to create effective BPP-delivery systems, including particle composition, size, and interfacial properties. The factors impacting the functional performance of colloidal delivery systems are then highlighted, including their loading capacity, encapsulation efficiency, protective properties, retention/release properties, and stability. Different kinds of colloidal delivery systems suitable for encapsulation of BPPs are then reviewed, such as microemulsions, emulsions, solid lipid particles, liposomes, and microgels. Finally, some examples of the use of colloidal delivery systems for delivery of specific BPPs are given, including hormones, enzymes, vaccines, antimicrobials, and ACE inhibitors. An emphasis is on the development of food-grade colloidal delivery systems, which could be used in functional or medical food applications. The knowledge presented should facilitate the design of more effective vehicles for the oral delivery of bioactive proteins and peptides.

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Can peptides be orally-delivered in crustaceans? The case study of the Crustacean Hyperglycaemic Hormone in Procambarus clarkii

Cited by 8 publications

References 37 publications

Detection and Control of Invasive Freshwater Crayfish: From Traditional to Innovative Methods

Detection and Control of Invasive Freshwater Crayfish: From Traditional to Innovative Methods

Acclimation to cyclic hypoxia improves thermal tolerance and copper survival in the caridean shrimp Palaemon varians

Recent Advances in Encapsulation, Protection, and Oral Delivery of Bioactive Proteins and Peptides using Colloidal Systems

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