Can PEI microgels become biocompatible upon betainization?

Şahiner, Nurettin; Demirci, Şahin

doi:10.1016/j.msec.2017.03.285

Cited by 33 publications

(40 citation statements)

References 28 publications

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“…For example, in the cosmetic industry as additives, in the pharmaceutical industry as drug delivery vehicles, as packaging materials, for water decontamination, separation and purification, membrane for filtation, tissue engineering and many other biomedical uses and catalysis are some the fields of investigation for HNTs applications. Recently, filling materials with nanoclays including HNTs were utilized as coating for surface protection and for cleaning purposes due to the surfaces being easily modifiable to generate necessary functionalities . Functionalized HNTs/chitosan composite with efficient cleaning properties for quartz glass surfaces, HNTs/starch nanocomposites incorporating antimicrobial peptides for food preservation, rosemary essential oil‐loaded HNTs nanocomposites for food packing, as well as CeO 2 ‐ZnO/HNTs nanocomposite, Ag‐ZnO/HNTs nanocomposite, amine modified Ag/HNTs, and lysozyme encapsulated HNTs were reported as antimicrobial HNTs‐based materials.…”

Section: Introductionmentioning

confidence: 99%

“…The change in the morphology of HNTs after modification was visualized by scanning electron microscope (SEM) and transmission electron microscope (TEM). Earlier, PEI‐modified HNTs were reported as a potential material in gene delivery applications and catalysis reactions . Furthermore, materials modified to have positively charged surfaces have many biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

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Functionalization of halloysite nanotubes with polyethyleneimine and various ionic liquid forms with antimicrobial activity

Suner

Şahiner

Akçalı

et al. 2019

J of Applied Polymer Sci

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Halloysite nanotube (HNT), a natural clay, was modified with branched polyethyleneimine (PEI) to form PEI‐HNT using epichlorohydrin (ECH) as coupling agent, then protonated with HCl to obtain H‐PEI‐HNTs providing [NH3]+[Cl]− functionality for potential antimicrobial properties. Upon PEI modification, zeta potential value of HNTs was increased to +37.3 mV from −34.5 mV and to +41.1 mV for H‐PEI‐HNTs. Only 1.87 wt % H‐element in HNT was increased to 3.03 wt % upon PEI modification along with newly generated elements of N and C at 2.99 and 9.93 wt %, respectively. Moreover, ionic liquid (IL) forms of HNTs with [NH3]+[N(CN)2]−, [NH3]+[PF6]− and [NH3]+[BF4]− functionality were generated via anion exchange of H‐PEI‐HNTs with sodium dicyanamide (SDC), ammonium hexafluorophosphate (AHFP), and sodium tetrafluoroborate (STFB). The antimicrobial properties of the modified, protonated, and IL forms of HNTs were determined via macro dilution, diffusion and agar screening tests against Escherichia coli ATCC 8739, Pseudomonas aeruginosa ATCC 10145, Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 6538 strains, and Candida albicans ATCC 10231 strains. It was found that H‐PEI‐HNTs possesses potent antimicrobial effect compared with the other forms of HNTs with 2–4 mg mL−1 MIC and 8–16 mg mL−1 MBC values via the macro dilution method. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48352.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Functionalization of halloysite nanotubes with polyethyleneimine and various ionic liquid forms with antimicrobial activity

Suner

Şahiner

Akçalı

et al. 2019

J of Applied Polymer Sci

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“…The blue curve in Figure b shows the FTIR spectrum of PNS‐HPAO‐PS. The band at 1168 cm −1 can be assigned to the valence vibration of SO bonds, and the characteristic peak of SO bonds is located at 1034 cm −1 . These spectral features suggest that 1,3‐PS has been attached to PNS‐HPAO spheres.…”

Section: Resultsmentioning

confidence: 90%

¹³¹I‐Labeled Multifunctional Polyphosphazene Nanospheres for SPECT Imaging‐Guided Radiotherapy of Tumors

Zhu

Zhao

Fan

et al. 2019

Adv Healthcare Materials

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Design of theranostic nanoplatforms represents a major topic for current nanomedicine. Here, the preparation of multifunctional poly(cyclotriphosphazene‐co‐polyethylenimine) nanospheres (PNSs) labeled with radionuclide 131I for single photon emission computed tomography (SPECT) imaging‐guided radiotherapy of tumors is reported. In this work, PNSs are prepared using hexachlorocyclotriphosphazene as a crosslinker to crosslink branched polyethylenimine (PEI) via a nucleophilic substitution reaction, modified with 3‐(4′‐hydroxyphenyl) propionic acid‐OSu (HPAO) for 131I labeling, and reacted with 1,3‐propane sulfonate (1,3‐PS) to render the particles with antifouling property, followed by acetylation of the remaining surface amines and labeling with 131I. The acquired PNS.NHAc‐HPAO(131I)‐PS particles are well characterized. It is shown that the multifunctional PNSs with an average size of 184 ± 29.3 nm exhibit favorable antifouling properties, high 131I labeling efficiency (76.05 ± 3.75%), and excellent radiostability and colloidal stability. With these properties owned, the developed PNS.NHAc‐HPAO(131I)‐PS spheres enable much more efficient SPECT imaging and radiotherapy of a xenografted tumor model in vivo than the PEI counterpart material (PEI.NHAc‐HPAO(131I)‐PS). The developed PNSs may be used as a versatile platform for further development of different forms of nanomedicine for various biomedical applications.

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“…Various methods, such as electrostatic complexation, inverse‐emulsion, self‐assembly of biopolymers, and precipitation polymerization method18a,28 have been adopted to synthesize different polymer‐based NGs. In particular for PEI‐based NGs, currently there are mainly three synthesis methods that have been used: 1) electrostatic complexation or interaction; 2) water‐in‐oil (W/O) emulsion; and 3) utilization of PEI as a chemical crosslinker.…”

Section: Synthesis Of Pei‐based Ng Systemsmentioning

confidence: 99%

Polyethylenimine‐Based Nanogels for Biomedical Applications

Zou

Shen

et al. 2019

Macromolecular Bioscience

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Nanogels (NGs) are 3‐dimensional (3D) networks composed of hydrophilic or amphiphilic polymer chains, allowing for effective and homogeneous encapsulation of drugs, genes, or imaging agents for biomedical applications. Polyethylenimine (PEI), possessing abundant positively charged amine groups, is an ideal platform for the development of NGs. A variety of effective PEI‐based NGs have been designed and much effort has been devoted to study the relationship between the structure and function of the NGs. In particular, PEI‐based NGs can be prepared either using PEI as the major NG component or using PEI as a crosslinker. This review reports the recent progresses in the design of PEI‐based NGs for gene and drug delivery and for bioimaging applications with a target focus to tackle the diagnosis and therapy of cancer.

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Can PEI microgels become biocompatible upon betainization?

Cited by 33 publications

References 28 publications

Functionalization of halloysite nanotubes with polyethyleneimine and various ionic liquid forms with antimicrobial activity

Functionalization of halloysite nanotubes with polyethyleneimine and various ionic liquid forms with antimicrobial activity

¹³¹I‐Labeled Multifunctional Polyphosphazene Nanospheres for SPECT Imaging‐Guided Radiotherapy of Tumors

Polyethylenimine‐Based Nanogels for Biomedical Applications

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Can PEI microgels become biocompatible upon betainization?

Cited by 33 publications

References 28 publications

Functionalization of halloysite nanotubes with polyethyleneimine and various ionic liquid forms with antimicrobial activity

Functionalization of halloysite nanotubes with polyethyleneimine and various ionic liquid forms with antimicrobial activity

131I‐Labeled Multifunctional Polyphosphazene Nanospheres for SPECT Imaging‐Guided Radiotherapy of Tumors

Polyethylenimine‐Based Nanogels for Biomedical Applications

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Product

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¹³¹I‐Labeled Multifunctional Polyphosphazene Nanospheres for SPECT Imaging‐Guided Radiotherapy of Tumors