Can Patients with Common Variable Immunodeficiency Have Allergic Rhinitis?

Agondi, Rosana Câmara; Barros, Myrthes Toledo; Kokron, Cristina Maria; Cohon, Andrea; Oliveira, Ana Karolina Barreto de; Kalil, Jorge; Giavina‐Bianchi, Pedro

doi:10.2500/ajra.2013.27.3855

Cited by 22 publications

(17 citation statements)

References 34 publications

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“…The other study where PID patients were evaluated recruited only common-variable immunodeficiency (CVID), and verified the presence of allergen sensitization in approximately 5.6% of the cases [14]. Allergen sensitization was observed in only 3.28% of the patients with CVID and an asthma diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Allergic diseases and allergen sensitization in a group of patients with PID have previously only been reported in 2 studies. One of these, performed in Turkey, presented a particular situation where 32.39% of the cohort of PID patients had a diagnosis of IgA deficiency or IgG-subclass deficiency, both conditions that usually present fewer infections than other PID [13,14]. This is a different profile of PID patients from that of our cohort, probably because our immunology clinic receives patients referred for recurrent infections, meaning the number of patients with an IgA or IgG-subclass deficiency is very low.…”

Section: Discussionmentioning

confidence: 99%

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Sensitization to Aeroallergens in Patients with Primary Immunodeficiencies

Segundo¹,

Canabrava²

2018

Int Arch Allergy Immunol

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Background: Primary immunodeficiencies (PID) are a heterogeneous group of diseases that cause alterations in the immune system, leading to the increased susceptibility to infections, autoimmune diseases, and malignancies. The aim was to evaluate the presence of clinical manifestations and diagnoses of asthma, rhinitis, and atopic dermatitis in patients diagnosed with PID, and correlate these with allergen sensitization verified by skin prick testing (SPT). Material and Methods: This cross-sectional, descriptive, and observational study was conducted from February 2015 to February 2016. We performed a medical report analysis and SPT for aeroallergens in patients with a PID diagnosis. Results: Thirty-one patients with a PID diagnosis were included. The mean age of the participants was 15.41 years. From the 31 patients, 28 had symptoms suggestive of allergic disease (asthma, rhinitis, and atopic dermatitis) and only 7 presented positive SPT for at least 1 aeroallergen. Conclusion: The frequency of allergenic sensitization in the group of patients with PID and symptoms suggestive of asthma, rhinitis, or atopic dermatitis is lower than that found in the general population, probably due the impairment of IgE formation secondary to their immunologic alterations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sensitization to Aeroallergens in Patients with Primary Immunodeficiencies

Segundo¹,

Canabrava²

2018

Int Arch Allergy Immunol

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“…100 Likewise, the same group found allergic rhinitis to be equally unusual. 101 Although 82% of the patients had a history of chronic or episodic rhinitis or rhinosinusitis, an allergic cause was confirmed only by detection of specific IgE to aeroallergens in 5.6% of the 72 patients with CVID with a clinical history suggestive of the diagnosis. This is in contrast to patients not having CVID with low or absent IgA levels with or without IgG subclass deficiency in whom allergic diseases, particularly asthma, are more common.…”

Section: Natural Historymentioning

confidence: 99%

International Consensus Document (ICON): Common Variable Immunodeficiency Disorders

Bonilla

Barlan

Chapel

et al. 2016

The Journal of Allergy and Clinical Immunology: In Practice

680

772

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The International Collaboration in Asthma, Allergy and Immunology initiated an international coalition among the American Academy of Allergy, Asthma & Immunology; the European Academy of Allergy and Clinical Immunology; the World Allergy Organization; and the American College of Allergy, Asthma & Immunology on common variable immunodeficiency. An author group was formed and then divided into individual committees. Within the committee, teams of authors were subgrouped to generate content for specific sections of the document. Content was derived from literature searches, relevant published guidelines, and clinical experience. After a draft of the document was assembled, it was collectively reviewed and revised by the authors. Where evidence was lacking or conflicting, the information presented represents the consensus expert opinion of the group. The full document was then independently reviewed by 5 international experts in the field, none of whom was among the authors of the original. The comments of these reviewers were incorporated before submission for publication.

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“…Although it is not part of current diagnostic criteria for CVID [1], many patients with CVID have low or undetectable levels of IgE [2]. Rates of specific IgE (serum and/or skin testing) measurement vary from 3 to 16% [2, 3] while as many as 82% of patients with CVID report symptoms consistent with allergies [2].…”

Section: To the Editormentioning

confidence: 99%