Can patient satisfaction with quality of life predict survival in advanced colorectal cancer?

Lis, Christopher G.; Gupta, Digant; Granick, J.; Grutsch, James F.

doi:10.1007/s00520-006-0100-3

Cited by 39 publications

(35 citation statements)

References 27 publications

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“…Improving quality of life (QOL), therefore, is important to optimize palliative care. Previous research in patients with advanced or metastatic lung, 2 breast, 3 colorectal, [4][5][6] head and neck, 7 bladder, 8 and cervical 9 cancers has shown an association between QOL and survival. A recent study demonstrated an association between QOL and overall survival (OS) in patients with RCC.…”

Section: Introductionmentioning

confidence: 99%

Quality of Life Predicts Progression-Free Survival in Patients With Metastatic Renal Cell Carcinoma Treated With Sunitinib Versus Interferon Alfa

Cella

Cappelleri

Bushmakin

et al. 2009

JOP

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Purpose: In a randomized phase III trial, sunitinib was associated with significantly superior progression-free survival (PFS) when compared with interferon alfa (IFN-␣) as first-line therapy in patients with metastatic renal cell carcinoma. We investigated whether baseline quality-of-life (QOL) and demographic and clinical variables were predictive for PFS. Methods:Patients were randomly assigned to receive sunitinib or IFN-␣ at a ratio of one to one. QOL was measured using the Functional Assessment of Cancer Therapy-General scale (FACT-G), the FACT-Kidney Symptom Index-Disease-Related Symptoms subscale (FKSI-DRS), and the EuroQol (EQ) Group's visual analog scale (EQ-VAS; Rotterdam, the Netherlands). In all scales, higher scores indicate better QOL or fewer symptoms. Controlling for other baseline demographic and clinical variables, Cox proportional hazards models-one for each QOL variable-were used to test if difference in baseline QOL scores predicted PFS. Results:The superior treatment effect on PFS of sunitinib versus IFN-␣ remained robust (hazard ratio [HR], 0.34, 0.33, and 0.33 for each model, respectively; P Ͻ .0001 for each model). Higher baseline FACT-G, FKSI-DRS, and EQ-VAS scores were associated with longer PFS (HR, 0.93, 0.89, and 0.91, respectively; P Յ .001, P Յ .001, and P ϭ .008, respectively). Presence of liver metastases (HR, 1.59 to 1.71; P ϭ .0009 to .0044) and number of Memorial Sloan-Kettering Cancer Center (MSKCC; New York, NY) risk factors (HR, 1.52 to 1.60; P Ͻ .0001 for each) were significant negative predictors of PFS, independent of other variables. Conclusion:Sunitinib conferred significantly superior PFS compared with IFN-␣, irrespective of baseline QOL or clinical characteristics. Higher baseline QOL correlated with longer PFS, whereas the presence of liver metastases and more MSKCC risk factors at baseline correlated with shorter PFS. This remains an area for future study.

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Section: Introductionmentioning

confidence: 99%

Quality of Life Predicts Progression-Free Survival in Patients With Metastatic Renal Cell Carcinoma Treated With Sunitinib Versus Interferon Alfa

Cella

Cappelleri

Bushmakin

et al. 2009

JOP

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“…Descriptive and exploratory studies -level 6 (19)(20)(21)(22) Controlled randomized clinical trial -level 2 (23) Qualitative, phenomenological -level 6 (24) Role, emotional, social, physical and mental functions. (27) Lis et al 2006 (28) Studies tested the correlation among genders (25) , age ranges (26) , described the difference between well-and malnourished patients (27) and investigated whether QoL predicts survival (28) .…”

Section: Discussionmentioning

confidence: 99%

“…Berkman-Syme Social Network Index (SNI) (20)(21) Centre for Epidemiological Studies Depression scale (CES-D) (16) EORTC Quality of Life Questionnaire Core-30 (QLQ-C30) (19,22,23,(25)(26)(27) EORTC Quality of Life Questionnaire Colorectal-38 (QLQ-CR38) (19,23,(25)(26) Functional Assessment of Cancer Therapy -Colorectal (FACT-C) (14)(15)(16) Functional Assessment of Cancer Therapy -General (FACT-G) (16) Hospital Anxiety and Depression Scale (HADS) (18,(22)(23) Medical Outcomes Study Short-Form 12 (SF-12) (18,21) Medical Outcomes Study Short-Form 36 (SF-36) (20) Nottingham Health Profile (NHP) (17) State-Trait Anxiety Inventory (STAI) (16) Satisfaction With Life Scale (SWLS) (14)(15)(16) The Ferrans and Powers Quality of life Index (QLI) (28) Obs. Notes refer to the articles that used each instrument.…”

Section: Instrumentsmentioning

confidence: 99%

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Fatores que influenciam a qualidade de vida de pacientes com câncer de cólon e reto

Nicolussi

Sawada

2010

Acta paul. enferm.

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Objective: To conduct an integrative literature review and evaluate the evidence regarding quality of life of patients with colon and rectal cancer. Methods: A literature search was conducted between 1997 and 2007 using the LILACS, CINAHL and MEDLINE databases. Results: The diagnosis and treatment of cancer affect several domains of quality of life of the sample of patients. A number of factors, such as, engaging in exercise, increased physical conditioning, good nutrition, and psychosocial support led to better quality of life. Conclusions: There was a lack of national publications, few publications by registered nurses, the predominance of descriptive studies, and weak level of evidence. We recommend that registered nurses conduct experimental studies to evaluate the effect of psychosocial interventions and physical activity programs in improving the quality of life of patients with cancer. Keywords: Quality of life; Colorectal neoplasms; Oncologic nursing. RESUMOObjetivo: Foi realizada uma revisão integrativa da literatura com o objetivo de avaliar as evidências disponíveis na literatura o conhecimento científico produzido relacionado à qualidade de vida (QV) do paciente adulto com câncer de cólon e reto. Métodos: Selecionamos artigos publicados nas bases de dados LILACS, CINAHL e MEDLINE, entre 1997 e 2007. Resultados: Encontramos que o diagnóstico e o tratamento para o câncer afetam vários domínios da QV do paciente e que fatores como a prática de exercícios, aumento da aptidão física, o estado de boa nutrição, a presença de suporte psicossocial e de rede social favorecem uma QV melhor. Conclusão: Como lacunas no conhecimento, detectamos falta de produção científica nacional, escassa contribuição do enfermeiro, predomínio de estudos descritivos, de nível de evidência considerado fraco. Sugerimos a atuação do enfermeiro em pesquisas de intervenções de suporte psicossocial e de programas de atividade física que possibilitem melhorar a QV do paciente oncológico. Descritores: Qualidade de vida; Neoplasias colorretais; Enfermagem oncológica. RESUMENObjetivo: Fue realizada una revisión integradora de la literatura con el objetivo de evaluar las evidencias disponibles en la literatura el conocimiento científico producido relacionado a la calidad de vida (CV) del paciente adulto con cáncer de colon y recto. Métodos: Seleccionamos artículos publicados en las bases de datos LILACS, CINAHL y MEDLINE, entre 1997 y 2007. Resultados: Encontramos que el diagnóstico y el tratamiento para el cáncer afectan varios dominios de la CV del paciente y que factores como la práctica de ejercicios, aumento de la aptitud física, el estado de buena nutrición, la presencia de soporte psicosocial y de red social favorecen una CV mejor. Conclusión: Como vacíos en el conocimiento, detectamos: falta de producción científica nacional, escasa contribución del enfermero y predominio de estudios descriptivos con un nivel de evidencia considerado débil. Sugerimos la actuación del enfermero en investigaciones de intervenciones de soporte...

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“…The goal of the study of Lis et al [6], published in this issue, was to evaluate the association between patient satisfaction with quality of life (QoL) and survival in colorectal cancer patients undergoing care in a community hospital comprehensive cancer center. On the basis of the results of 177 patients, the authors report that baseline patient satisfaction with QoL provides useful prognostic information in patients with colorectal cancer independent of tumor stage at diagnosis and prior treatment history.…”

Section: Imagine Scientists Can Predict My and Your Survival…mentioning

confidence: 99%

Imagine, scientists can predict my and your survival…

Porzsolt

2006

Support Care Cancer

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Can patient satisfaction with quality of life predict survival in advanced colorectal cancer?

Cited by 39 publications

References 27 publications

Quality of Life Predicts Progression-Free Survival in Patients With Metastatic Renal Cell Carcinoma Treated With Sunitinib Versus Interferon Alfa

Quality of Life Predicts Progression-Free Survival in Patients With Metastatic Renal Cell Carcinoma Treated With Sunitinib Versus Interferon Alfa

Fatores que influenciam a qualidade de vida de pacientes com câncer de cólon e reto

Imagine, scientists can predict my and your survival…

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