CAN ONE MUSCLE REINNERVATE ANOTHER? A Preliminary Study of Muscular Neurotization in the Rabbit

Miller, Timothy A.; Korn, Howard N.; Wheeler, Ervin S.; Eldriuge, Lynn

doi:10.1097/00006534-197801000-00009

Cited by 18 publications

(3 citation statements)

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“…By histochemical and electromyographic method, muscle neutrotization has also been documented in the laboratory. 9 No functional deficit were noticed in any of our patients. Hence, only aesthetic parameters were assessed in our study.…”

Section: Discussionmentioning

confidence: 48%

Retrospective Subjective Evaluation of Aesthetic Outcome in Secondary Cleft Lip Deformities Operated with Abbe's Flap

2015

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The distribution of cleft lip and palate in literature iscleft lip and palate at 46%, followed by isolated cleft palate at 33%, then isolated cleft lip at 21%. The majority of bilateral cleft lips (86%) and unilateral cleft lips (68%) are associated with cleft palate. Males are predominant in cleft lip and palate population, whereas females have more of isolated cleft palates. 1 The primary cleft lip surgery has undergone vast improvement in technique, but revision of residual lip deformity continues to be a major challenge. The marked horizontal tightness of the cleft upper lip attributes to deficient tissue and intense scarring. The situation is ABSTRACT Background: The Abbe's flap is most commonly used to repair the full thickness defects of the lip that do not involve the commissure. The Abbe flap was first introduced to correct the secondary deformity of bilateral cleft lip. By this pedicled flap, we are able to equalize the disparity which existed between the tight upper lip and excessive lower lip. Aims to study retrospective subjective evaluation of aesthetic outcome in secondary cleft lip deformities operated with Abbe's flap. Methods: 29 patients operated during the period of January 2007-December 2011 for correction of secondary cleft lip and nasal deformity with Abbe's flap with or without rhinoplasty were included in our retrospective study. The secondary corrective surgeries were performed by a single surgeon. The photographs of the patients were retrospectively assessed by two plastic surgeons and one oral and maxillofacial surgeon, other than the one who performed the surgery. 29 patients operated during the period of January 2007-December 2011 for correction of secondary cleft lip and nasal deformity with Abbe's flap with or without rhinoplasty were included in our retrospective study. The secondary corrective surgeries were performed by a single surgeon. The photographs of the patients were retrospectively assessed by two plastic surgeons and one oral and maxillofacial surgeon, other than the one who performed the surgery. Results: Out of 29 patients with secondary cleft deformities 12 were male and 17 were female. Average follow up period was 3 years. Multiple variables of the nose and the lips were used to assess the aesthetic outcome of Abbe's flap. Conclusion: As per the subjective retrospective analysis of our study we have come to the conclusion that Abbe's flap is a work horse for correction of shortage of tissue for the secondary cleft lip deformities. Uniform satisfactory outcome was obtained with a more natural contour and more satisfactory proportion of both lips.

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Section: Discussionmentioning

confidence: 48%

Retrospective Subjective Evaluation of Aesthetic Outcome in Secondary Cleft Lip Deformities Operated with Abbe's Flap

2015

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“…During the surgical approach to the EDL for transplantation, the epimysium of both the TA and PL is damaged. The removal of the epimysium from both paralyzed and healthy muscles has been used by surgeons to enhance the possibility of reinnervation of the damaged myofibers by nerves to the surrounding healthy myofibers as shown by a number of investigators (Brown, 1984;Miller et al, 1978;Erlacher, 1915). Therefore, the removal of part of the epimysium from the TA and PL might enhance the possibility that the axons from these muscles may reinnervate the graft.…”

Section: Discussionmentioning

confidence: 99%

“…The reinnervation of muscle grafts, which during the transplantation procedures are denervated, has also been examined. Using Erlacher's techniques, Miller et al (1978) showed reinnervation of a muscle graft in the rabbit. The criterion for reinnervation in this study was changes in the histochemical profile of the reinnervated muscle.…”

Section: Erlachermentioning

confidence: 99%

Role of muscle neurotization in the reinnervation of murine muscle grafts

Klueber

1987

Anat. Rec.

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Although the reinnervation of muscle grafts has been demonstrated, the question remains as to the source of neurons reinnervating the graft. A muscle graft could be reinnervated by its original neurons (neural neurotization) or by sprouting of axons which supply the intact myofibers of surrounding muscles (muscle neurotization). The objective of this study was to evaluate the role of muscle neurotization in the reinnervation process using both horseradish peroxidase and fluorescent tracers. Observations from 20 muscle grafts indicate that the neurons reinnervating the grafts are from the original motor neuron pool. Thus muscle neurotization may not occur during the reinnervation process.

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The surgical treatment of extratemporal facial paralysis: An overview

Conley

Baker

1978

Head Neck

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At present there is no single surgical approach that is ideally suited to rehabilitation of the paralyzed face. Dynamic reconstruction and neural reconstitution are usually preferred to static methods, except under special circumstances. Experience with over 150 autogenous facial-nerve grafts using epineural suture technique has resulted in return of movement in 95% of properly selected patients. When grafting is not feasible, as in the obliterated central facial nerve, hypoglossal-facial-nerve crossover is a simple and powerful source of reinnervation, usually resulting in minimal intraoral crippling and mild mass movement. A newer procedure, the cross-face nerve graft, is an alternative to hypoglossal crossover, although it results in less axonal input and longer regenerative time. In cases of long-standing facial paralysis with muscle atrophy, temporalis and masseter transfers are dependable and may sometimes be combined with a nerve graft.

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CAN ONE MUSCLE REINNERVATE ANOTHER? A Preliminary Study of Muscular Neurotization in the Rabbit

Cited by 18 publications

References 0 publications

Retrospective Subjective Evaluation of Aesthetic Outcome in Secondary Cleft Lip Deformities Operated with Abbe's Flap

Retrospective Subjective Evaluation of Aesthetic Outcome in Secondary Cleft Lip Deformities Operated with Abbe's Flap

Role of muscle neurotization in the reinnervation of murine muscle grafts

The surgical treatment of extratemporal facial paralysis: An overview

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