Can Neutrophil Lymphocyte Ratio Predict Mortality in Acute Non Variceal Upper Gastrointestinal Bleeding?

Abstract

BACKGROUND: Acute non-variceal upper gastrointestinal bleeding (NVUGIB) is one of the common gastrointestinal problems and has a high mortality, especially in patients with poor hemodynamics. Therefore, treatment and follow-up should be managed dynamically. Neutrophil-lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) are fast workable, cheap, and easy to calculate hematological parameters. We need easily accessible parameters as well as routine classifications such as Rockall score in the treatment and follow-up of NVUGIB patients, whose hemodynamics are unstable and progress with high mortality. In this study, we planned to evaluate NLR and PLR levels in patients with NVUGIB in the treatment follow-up with other scoring systems and their relationship with mortality in these patients. METHODS:Two hundred and forty-nine patients who were admitted to our clinic between January 2015 and January 2017 diagnosed with NVUGIB, and who underwent necessary examinations and follow-ups, were included in the study. The patients' Glasgow Blacthford, Rockall Score, NLR, and PLR levels were calculated at the first admission. RESULTS:One hundred and fifty-six of the patients were male (70.6%) and the mean age of all patients was 64.5±18.0 years. After follow-up and treatment, 28 (11.2%) patients died due to bleeding. High NLR and tachycardia at the time of admission and high patient age were found to be independent risk factors affecting the long of hospital stay. High Rockall score, high NLR at admission, and hypotension at admission were shown to be independent risk factors affecting mortality. CONCLUSION:Besides the use of various scoring systems in patients with NVUGIB, we think that the use of simple hematological parameters may be appropriate and the use of these hematological parameters may be useful in the management of patients with unstable hemodynamics.

The role of neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio, and systemic immune inflammation index in predicting the necessity for surgery and therapeutic surgery in patients with anterior abdominal stab wounds

“…5 Inflammatory markers and the systemic immune inflammation index (SII) have been investigated to determine prognosis in various conditions such as sepsis, gastrointestinal bleeding, pancreatitis, cancer, and even obesity. [6][7][8][9][10] AASW constitutes a form of trauma that can potentially trigger an inflammatory response in patients. However, there exists a notable gap in the existing literature regarding high-quality studies elucidating the predictive value of inflammatory parameters for timely decision-making in AASW patients, particularly concerning the necessity for surgical intervention in cases that may not be readily diagnosable through physical examination.…”

“…Inflammatory markers and the systemic immune inflammation index (SII) have been investigated to determine prognosis in various conditions such as sepsis, gastrointestinal bleeding, pancreatitis, cancer, and even obesity 6–10 . AASW constitutes a form of trauma that can potentially trigger an inflammatory response in patients.…”

Diagnostic Value of HALP Score in Detecting Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus

“…In recent years, lymphocyte count has been used in a number of different scoring systems. 13,14 Platelet/lymphocyte ratio (PLR), NLR, monocyte/lymphocyte ratio (MLR), and systemic immuneinflammation index (SII) have all included lymphocyte counts as a parameter of systemic inflammation marker in the scoring systems. 13,14 Platelets functions in hemostasis are well described but recently its effects on angiogenesis, tumor metastasis, and cancer-related inflammation have been investigated.…”

“…13,14 Platelet/lymphocyte ratio (PLR), NLR, monocyte/lymphocyte ratio (MLR), and systemic immuneinflammation index (SII) have all included lymphocyte counts as a parameter of systemic inflammation marker in the scoring systems. 13,14 Platelets functions in hemostasis are well described but recently its effects on angiogenesis, tumor metastasis, and cancer-related inflammation have been investigated. When HALP score was first created it was used to predict the outcome of cancer patients and since then it has been widely investigated in cancer patients.…”

“…In recent years, lymphocyte count has been used in a number of different scoring systems. 13 14 Platelet/lymphocyte ratio (PLR), NLR, monocyte/lymphocyte ratio (MLR), and systemic immune-inflammation index (SII) have all included lymphocyte counts as a parameter of systemic inflammation marker in the scoring systems. 13 14…”