Can neoadjuvant radiochemotherapy improve the results of multivisceral resections in advanced rectal carcinoma (cT4a)

Abstract

Together with curative extended multivisceral resection nRCT can improve prognosis in patients with advanced rectal carcinoma (cT4a).

Multivisceral Resection for Locally Advanced Rectal Cancer: Prognostic Factors Influencing Outcome

“…clinical guidelines and results of different studies published in the literature indicate that when complete excision is feasible, the surgical approach in these patients is multivisceral because despite a higher morbidity, it has been shown to increase long-term survival (1-4, 7, 8). the incidence of multivisceral resection for locally advanced rectal cancer of 4.1% (30 patients) in our series is similar to that reported by others (1)(2)(3)(4)(5)(6). Histopathologically, adhesions to surrounding structures were due to tumor invasion in 66.7% of the cases.…”

Colorectal cancer in Slovenia at the turn of the century

“…These include local resection, transabdominal resection, and adjuvant radiochemotherapy. Most European investigators advocate preoperative intensive shortcourse irradiation instead [4,10,16,19]. Patients with rectal tumors invading into the muscularis propria can benefit from preoperative radiochemotherapy [1,2,18].…”

Prognostic value of tumour regression grading and depth of neoplastic infiltration within the perirectal fat after combined neoadjuvant chemo-radiotherapy and surgery for rectal cancer

“…[1][2][3][4] A reliable method of assessing response to adjuvant treatment is required to help standardise the assessment of new forms of multimodal therapy.…”