Can Necrosis and Ovarian Vein Thrombus Be a Serious Complication in Morbidly Adherent Placenta?

Vettorazzi, Janete; Salazar, Cristiano Caetano; Bigolin, André Vicente; Raupp, Gustavo dos Santos; Cosner, Adelar Magnabosco; Garcia, Tiago Selbach; Schroeder, G; Mussnich, Heloísa Guedes; Arlindo, Ellen Machado

doi:10.4236/ojog.2021.1111138

Cited by 1 publication

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“…In addition to morphological changes in the placenta, overcrowded conceptuses, a high incidence of fetal growth restriction (FGR) in AM +/intercrosses, and embryonic loss occurring between E9.5 and E12.5 are the main reasons for the reduced fertility observed in female AM +/mice (76). This is consistent with the circumstance that except for hemorrhage or other adverse maternal pregnancy outcomes, clinical PAS patients possibly have FGR in some cases (104)(105)(106).…”

Section: Invasion Of the Placentasupporting

confidence: 87%

Animal models of the placenta accreta spectrum: current status and further perspectives

2023

Front. Endocrinol.

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Placenta accreta spectrum disorder (PAS) is a kind of disease of placentation defined as abnormal trophoblast invasion of part or all of the placenta into the myometrium, even penetrating the uterus. Decidual deficiency, abnormal vascular remodeling in the maternal–fetal interface, and excessive invasion by extravillous trophoblast (EVT) cells contribute to its onset. However, the mechanisms and signaling pathways underlying such phenotypes are not fully understood, partly due to the lack of suitable experimental animal models. Appropriate animal models will facilitate the comprehensive and systematic elucidation of the pathogenesis of PAS. Due to the remarkably similar functional placental villous units and hemochorial placentation to humans, the current animal models of PAS are based on mice. There are various mouse models induced by uterine surgery to simulate different phenotypes of PAS, such as excessive invasion of EVT or immune disturbance at the maternal–fetal interface, which could define the pathological mechanism of PAS from the perspective of the “soil.” Additionally, genetically modified mouse models could be used to study PAS, which is helpful to exploring the pathogenesis of PAS from the perspectives of both “soil” and “seed,” respectively. This review details early placental development in mice, with a focus on the approaches of PAS modeling. Additionally, the strengths, limitations and the applicability of each strategy and further perspectives are summarized to provide the theoretical foundation for researchers to select appropriate animal models for various research purposes. This will help better determine the pathogenesis of PAS and even promote possible therapy.

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Section: Invasion Of the Placentasupporting

confidence: 87%

Animal models of the placenta accreta spectrum: current status and further perspectives

2023

Front. Endocrinol.

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show abstract

Can Necrosis and Ovarian Vein Thrombus Be a Serious Complication in Morbidly Adherent Placenta?

Cited by 1 publication

References 19 publications

Animal models of the placenta accreta spectrum: current status and further perspectives

Animal models of the placenta accreta spectrum: current status and further perspectives

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