Can natural strain and strain rate quantify regional myocardial deformation? A study in healthy subjects

Kowalski, Mirosław; Kukulski, Tomasz; Jamal, F; D’hooge, Jan; Weidemann, Frank; Rademakers, Frank; Bijnens, Bart; Hatle, Liv; Sutherland, George R.

doi:10.1016/s0301-5629(01)00388-x

Cited by 243 publications

(166 citation statements)

References 25 publications

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“…Reported radial strain values in humans using tissue Doppler imaging range from 18 -48% (34,35). Peak radial strain was 39.6 Ϯ 8.9% using PC-MR in the shortaxis view in normal human volunteers (11).…”

Section: Discussionmentioning

confidence: 99%

Persistent decline in longitudinal and radial strain after coronary microembolization detected on velocity encoded phase contrast magnetic resonance imaging

Dicks

Carlsson

Heiberg

et al. 2009

Magnetic Resonance Imaging

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Purpose:To use velocity-encoded phase contrast (PC) MRI in assessing the effect of coronary microembolization on longitudinal and radial myocardial strain. Materials and Methods:A combined X-ray and MR system (XMR) was used for selective left anterior descending artery catheterization and microinfarct assessment in swine (n ϭ 6). The embolized area at risk was defined on perfusion MRI followed by administration of a 7500 count (size ϭ 100 -300 m) of the embolic agent. Quantification of strain and microinfarction was performed at 1 h and 1 week using PC-MRI and delayed enhancement (DE) MRI, respectively. At postmortem, sliced hearts were stained to define microinfarction.Results: Baseline longitudinal and radial strain did not differ between area-at-risk and remote myocardium. The embolized territory (area at risk) showed significant decline in longitudinal strain from Ϫ11.5 Ϯ 3.2% to 1.8 Ϯ 2.5% at 1 h (P Ͻ 0.05) and Ϫ3.9 Ϯ 1.1% at 1 week (P Ͻ 0.05). Similarly, regional radial strain progressively declined from 23.6 Ϯ 2.5% at baseline to 12.5 Ϯ 3.7% at 1 h (P Ͻ 0.05) and 4.8 Ϯ 5.0% at 1 week (P Ͻ 0.01). The size of microinfarction was not significantly different between DE-MRI and histochemical staining. Conclusion:PC-MRI is sensitive in assessing changes in regional longitudinal and radial strain after coronary embolization. Longitudinal and radial strain of the hyperenhanced patchy microinfarction demonstrates persistent decline over the course of 1 week.

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Section: Discussionmentioning

confidence: 99%

Persistent decline in longitudinal and radial strain after coronary microembolization detected on velocity encoded phase contrast magnetic resonance imaging

Dicks

Carlsson

Heiberg

et al. 2009

Magnetic Resonance Imaging

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“…Of particular interest have been the measurement of myocardial contractility (Heimdal et al 1998;Kanai et al 1999;Kowalski et al 2001;McDicken et al 1992) and the measurement of tissue mechanical properties (Gao et al 1996;Ophir et al 1991Ophir et al , 1999. Over this period, there have been relatively few publications describing applications of these methods to brain imaging.…”

Section: Introductionmentioning

confidence: 99%

Tissue Pulsatility Imaging of Cerebral Vasoreactivity During Hyperventilation

Kucewicz

Dunmire

Giardino

et al. 2008

Ultrasound in Medicine & Biology

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Tissue Pulsatility Imaging (TPI) is an ultrasonic technique that is being developed at the University of Washington to measure tissue displacement or strain due to blood flow over the cardiac and respiratory cycles. This technique is based in principle on plethysmography, an older non-ultrasound technology for measuring expansion of a whole limb or body part due to perfusion. TPI adapts tissue Doppler signal processing methods to measure the "plethysmographic" signal from hundreds or thousands of sample volumes in an ultrasound image plane. This paper presents a feasibility study to determine if TPI can be used to assess cerebral vasoreactivity. Ultrasound data were collected transcranially through the temporal acoustic window from four subjects before, during, and after voluntary hyperventilation. In each subject, decreases in tissue pulsatility during hyperventilation were observed that were statistically correlated with the subject's end-tidal CO 2 measurements.

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“…Post-hoc power analysis showed that, with a power of 80% and a two-sided significance level (alpha) of Po0.05, a 3.3% change in TVI Et could be detected in 19 patients, with a correlation coefficient between two measurements under equal circumstances of X0.75 and variation-coefficient for TVI Et of 7.1% (Kowalski et al, 2001).…”

Section: Statisticsmentioning

confidence: 99%

Evaluation of sub-acute changes in cardiac function after cisplatin-based combination chemotherapy for testicular cancer

et al. 2009

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Long-term cardiovascular morbidity is increasingly observed in chemotherapy-treated testicular cancer survivors, but little is known of early sub-clinical changes in cardiac function. We prospectively evaluated cardiac function in testicular cancer patients by echocardiography. Systolic (Wall Motion Score Index) and diastolic (E/A-ratio and Tissue Velocity Imaging (TVI)) parameters, and serum levels of N-Terminal pro-Brain Natriuretic Peptide (NT-proBNP) were assessed before the start of chemotherapy and 1 year later. Echocardiography data were compared with an age-matched group of healthy controls. Forty-two patients treated with bleomycin, etoposide and cisplatin were evaluated (median age 27 years, range 18 -50). Systolic function and E/A-ratio did not change, whereas the median TVI decreased (12.0 vs 10.0 cm s À1 ; P ¼ 0.002). Median levels of NT-proBNP increased (5 vs 18 pmol l À1 , P ¼ 0.034). Compared with controls, TVI before the start of chemotherapy was not significantly different. In conclusion, we found that at a median of 10 months after cisplatin-based treatment for testicular cancer, TVI decreased significantly, indicating a deterioration of diastolic cardiac function. Serum levels of NT-proBNP increased. The prognostic significance of these changes for future cardiovascular morbidity is not clear.

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Can natural strain and strain rate quantify regional myocardial deformation? A study in healthy subjects

Cited by 243 publications

References 25 publications

Persistent decline in longitudinal and radial strain after coronary microembolization detected on velocity encoded phase contrast magnetic resonance imaging

Persistent decline in longitudinal and radial strain after coronary microembolization detected on velocity encoded phase contrast magnetic resonance imaging

Tissue Pulsatility Imaging of Cerebral Vasoreactivity During Hyperventilation

Evaluation of sub-acute changes in cardiac function after cisplatin-based combination chemotherapy for testicular cancer

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