Can Natural Products Suppress Resistant Helicobacter pylori to Fight Against Gastric Diseases in Humans?

Abstract

More than 50% of the world's population is infected with Helicobacter pylori. H. pylori is the major causative agent of gastric ulcers and gastric cancer. H. pylori eradication using antibiotics either alone or together with a proton pump inhibitor is the primary strategy to decrease the incidence of gastric cancer. Although eradication therapy is effective, there are significant adverse effects and more importantly, resistance to antibiotics occurs, which represents a major therapeutic challenge. Multiple natural products have been shown to suppress H. pylori both in vitro and in animal model systems. However, only a handful of natural products have been evaluated in human clinical trials. The focus of this review is to summarize the results of published human clinical trials to assess the ability of natural products to reduce or eliminate H. pylori infections. Current evidence suggests that these products appear to have great potential to be developed as pharmaceutical candidates for eradication of H. pylori, hopefully both antibiotic-sensitive and antibiotic-resistant strains. Frequent consumption of locally produced foodstuff for controlling H. pylori infection in different countries around the world may well be a feasible long-term solution to fight against this worldwide prevalent pathogen.

Review of Functional and Pharmacological Activities of Berries

“…The effect of berries on H. pylori infection is also approved in human trials by using cranberries, which contains active fractions of quercetin and epicatechin [ 50 ]. The randomized, controlled, double-blind multicentric trial carried out in 295 asymptomatic children positive for H. pylori shows that regular or frequent cranberry juice consumption could be helpful therapy in asymptomatic children with H. pylori infections [ 126 ]. Cranberry fruit and its extracts inhibit H. pylori and show anti-adhesive, anti-inflammatory, and antibacterial bioactivities [ 127 ].…”

The tibetan medicine Zuozhu-Daxi can prevent Helicobacter pylori induced-gastric mucosa inflammation by inhibiting lipid metabolism

“…On the one hand, these medicines can inhibit H. pylori enzymes such as urease, which decreases the acidity of gastric juice. On the other hand, they can inhibit the adhesion of H. pylori to gastric mucosa [ 57 ]. In addition, some TCMs that play an antibacterial role by targeting biofilms, proteins of the primary metabolism and virulence factors of H. pylori , have received more attention [ 58 ].…”

Dietary Black Raspberry Supplementation as Natural Polyphenol Source Against Mild Dementia Patients with Overweight and Helicobacter pylori Infection

“…This merits exploration regarding treatments that can target these pathways, providing more favorable in ammatory pro les and hopefully reducing AD incidence. One potential treatment route may be a dietary modi cation, which has been demonstrated to affect both obesity and H. pylori infection by modulating the gut microbiome and in ammatory cascades 13,14 . Our previous research has highlighted the role of black raspberries (BRBs) in autoimmune and malignant conditions and found that in certain situations, BRBs and their metabolic components suppress pro-in ammatory markers and foster gut microbiota with less in ammatory pro les.…”