Can Myocardial Infarct Size Be Reduced by Mechanically Unloading the Left Ventricle?

Kloner, Robert A.

doi:10.1161/circulationaha.113.003976

Cited by 2 publications

(2 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The goal of an MCS device is to not only generate adequate blood pressure and flow, but to unload the LV. In doing so, myocardial protection and preservation are optimized (41,(85)(86)(87)(88)(89)(90)(91)(92)(93)(94), and the extent of lung injury is minimized (95)(96)(97). Venoarterial extracorporeal membrane oxygenation (VA ECMO) however does not unload the LV (87,94).…”

Section: Acute Left Ventricular Systolic Heart Failure-induced Cardio...mentioning

confidence: 99%

Application of Cardiovascular Physiology to the Critically Ill Patient

Bronicki,

Tume,

Gomez

et al. 2023

Critical Care Medicine

View full text Add to dashboard Cite

Objectives: To use the ventricular pressure–volume relationship and time-varying elastance model to provide a foundation for understanding cardiovascular physiology and pathophysiology, interpreting advanced hemodynamic monitoring, and for illustrating the physiologic basis and hemodynamic effects of therapeutic interventions. We will build on this foundation by using a cardiovascular simulator to illustrate the application of these principles in the care of patients with severe sepsis, cardiogenic shock, and acute mechanical circulatory support. Data Sources: Publications relevant to the discussion of the time-varying elastance model, cardiogenic shock, and sepsis were retrieved from MEDLINE. Supporting evidence was also retrieved from MEDLINE when indicated. Study Selection, Data Extraction, and Synthesis: Data from relevant publications were reviewed and applied as indicated. Conclusions: The ventricular pressure–volume relationship and time-varying elastance model provide a foundation for understanding cardiovascular physiology and pathophysiology. We have built on this foundation by using a cardiovascular simulator to illustrate the application of these important principles and have demonstrated how complex pathophysiologic abnormalities alter clinical parameters used by the clinician at the bedside.

show abstract

Section: Acute Left Ventricular Systolic Heart Failure-induced Cardio...mentioning

confidence: 99%

Application of Cardiovascular Physiology to the Critically Ill Patient

Bronicki,

Tume,

Gomez

et al. 2023

Critical Care Medicine

View full text Add to dashboard Cite

show abstract

“…As a result, new mechanical circulatory support devices have been developed for clinical use. These devices support cardiac function by collecting blood from: 1) the LV and delivering it into the ascending aorta ( 135 , 146 , 147 ); or 2) the left atrium and delivering the blood to the femoral artery by centrifugal bypass ( 135 , 148 , 149 , 150 ). Two of these devices are the FDA-approved TandemHeart (left atrial-to-femoral arterial ventricular assist device) (LivaNova PLC, London, United Kingdom) and Impella (Axial flow pump) LV support systems (Abiomed Inc., Danvers, Massachusetts).…”

Section: The Translational Role Of Large Animal Models Of Hf: a Critimentioning

confidence: 99%

Large Animal Models of Heart Failure

Silva

Emter

2020

JACC: Basic to Translational Science

View full text Add to dashboard Cite

Highlights Preclinical large animal models play a critical and expanding role in translating basic science findings to the development and clinical approval of novel cardiovascular therapeutics. This state-of-the-art review outlines existing methodologies and physiological phenotypes of several HF models developed in large animals. A comprehensive list of porcine, ovine, and canine models of disease are presented, and the translational importance of these studies to clinical success is highlighted through a brief overview of recent devices approved by the FDA alongside associated clinical trials and preclinical animal reports. Increasing the use of large animal models of HF holds significant potential for identifying new mechanisms underlying this disease and providing valuable information regarding the safety and efficacy of new therapies, thus, improving physiological and economical translation of animal research to the successful treatment of human HF.

show abstract

Can Myocardial Infarct Size Be Reduced by Mechanically Unloading the Left Ventricle?

Cited by 2 publications

References 24 publications

Application of Cardiovascular Physiology to the Critically Ill Patient

Application of Cardiovascular Physiology to the Critically Ill Patient

Large Animal Models of Heart Failure

Contact Info

Product

Resources

About