Can mycosis fungoides begin in the epidermis? A hypothesis

Ryan, Elizabeth A.; Sanderson, K.V.; Barták, Petr; Samman, P.D.

doi:10.1111/j.1365-2133.1973.tb15444.x

Cited by 90 publications

(40 citation statements)

References 33 publications

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“…They suggested that these cells are important in the pathogenesis of the disease. Ryan et al [29] described U cells as originating from Langerhans' cells and evolving towards lymphoid cells; they probably studied the indeterminate cells. Toribio et al [39] suggested the same hypothesis in a case of Woringer-Kolopp's disease, they observed 'Pagetoid' cells comparable to Langerhans' cells, but without the cytoplasmatic Langerhans' granules.…”

Section: Discussionmentioning

confidence: 99%

Microenvironment of Woringer-Kolopp’s Disease

1982

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A localized form of ‘Pagetoid reticulosis’ (Woringer-Kolopp’s disease) is described morphologically. It can be shown that ultrastructurally the ‘Pagetoid cells’ are heterogenic and that different cell types can be distinguished: there are lymphoid cells, which often look like Lutzner cells, and nonlymphoid cells which can be characterized as indeterminate cells or Langerhans’ cells. Often a close topographical relation between lymphoid and nonlymphoid cells can be demonstrated. This finding is suggestive for a functional interaction between the lymphoid cells, which are most probably T cells, and indeterminate cells and Langerhans’ cells, which are known to be important for the thymus-dependent immune reaction. The presence of the nonlymphoid cell population in the epidermis in Woringer-Kolopp’s disease seems to build up the specific microenvironment for lymphoid cell reaction.

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Section: Discussionmentioning

confidence: 99%

Microenvironment of Woringer-Kolopp’s Disease

1982

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“…Hypopigmented MF (HMF) is a clinical variant, first described by Ryan et al [3] in 1973. Although HMF is not an MF subtype recognized by the World Health Organization (WHO) or the European Organisation for Research and Treatment of Cancer (EORTC) classification (2005), it can present with some peculiar characteristics different from the classical form.…”

Section: Introductionmentioning

confidence: 99%

Hypopigmented Mycosis Fungoides versus Mycosis Fungoides with Concomitant Hypopigmented Lesions: Same Disease or Different Variants of Mycosis Fungoides?

et al. 2014

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Background: Hypopigmented mycosis fungoides (HMF) is a rare subtype of mycosis fungoides (MF). We compared patients with exclusive hypopigmented lesions with a group of MF patients with concomitant different lesions. Methods: 20 patients with HMF only and 14 patients with hypopigmented lesions concomitant with other types of lesions (mixed MF, MMF) were selected. Clinical-epidemiological analysis as well as histological and immunohistochemical studies were performed. Results: HMF and MMF preserve some similarities, like predilection for dark-skinned persons and slow progression, but they also present differences: the exclusive variant is associated with early onset and a clear CD8+ immunophenotype, whereas MMF patients tend to present a predominance of CD4+ cell infiltrates. Histological analysis revealed similar findings; relapsing courses were common. Conclusion: Whether patients are suffering from exclusive HMF or MMF, the presence of hypopigmented lesions can be considered a marker of good prognosis in MF, since both groups presented similar data, such as staging and disease duration.

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“…In such a case these cells might be derived from Langerhans cells, in spite of the absence of cytoplasmic Langerhans granules. This is also the hypothesis of R ayn et ai [17] with regard to mycosis fungoides and about mycosis cell provenance. In our case, the early histologic changes ( fig.…”

Section: Discussionmentioning

confidence: 94%

Woringer-Kolopp Disease

Toribio¹,

Pa²,

Tr³

1978

Dermatology

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A typical clinical and histologic case of so-called ‘pagetoid reticulosis’ or Woringer-Kolopp disease is reported. This is a chronic cutaneous condition usually with a single focus or at most with a few patches confined to a circumscribed region. A disseminated form has been described as Dupont-Vandaele type, but its relationship to the classic Woringer-Kolopp disease is uncertain. The nosological location of pagetoid reticulosis has not been established, but there are reasons to regard it as a particular and well-defined entity. In relation to the nature of this condition and to the origin of the ‘pagetoid cells’, it is tempting to consider the possibility that Woringer-Kolopp disease might be a lymphoproliferative epidermotropic disorder, classifiable as a benign form of ‘cutaneous T-cell lymphoma’, but the early histologic changes are rather indicative of an epidermal origin.

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Can mycosis fungoides begin in the epidermis? A hypothesis

Cited by 90 publications

References 33 publications

Microenvironment of Woringer-Kolopp’s Disease

Microenvironment of Woringer-Kolopp’s Disease

Hypopigmented Mycosis Fungoides versus Mycosis Fungoides with Concomitant Hypopigmented Lesions: Same Disease or Different Variants of Mycosis Fungoides?

Woringer-Kolopp Disease

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