Can Monocyte/HDL Ratio Be Used in the Follow-Up of Patients with Acromegaly?

Abstract

Objective: Insulin-like growth factor-1 (IGF-1) level was used in the follow-up of acromegaly patients. The aim of this study is to investigate the relationship between pre-and postoperative IGF-1 levels and monocyte/high-density lipoprotein (HDL) ratio, which is a novel inflammatory marker, in patients diagnosed with acromegaly.Material and Methods: Thirty-two acromegaly patients (17 males and 15 females) were included in this retrospective study. Demographic characteristics of the patients and their laboratory data before and six months after the operation were scanned from their files.Results: While preoperative IGF-1 level was 515.8 ± 197.0 ng/ml, postoperative IGF-1 level was 121.1 ± 89.4 ng/ml. While preoperative MHR was 13.9 ± 4.33 µl/mg/dl, it was calculated as 9.52 ± 4.43 µl/ mg/dl postoperatively. There was a significant difference in pre-and postoperative IGF-1 levels and monocyte/HDL ratio (p= 0.006 and p< 0.001, respectively). A positive relationship was found between the pre-and post-operative monocyte/HDL ratio and IGF-1 levels. (p< 0.001 vs β= 0.727 and p= 0.001 vs β= 0.540, respectively). Conclusion:IGF-1 level is correlated with the monocyte/HDL ratio. In addition to IGF-1 level, monocyte/HDL ratio may also be directive during the follow-up of patients with acromegaly and especially for complications that may develop. Prospective and randomized studies with large patient groups are needed to give more detailed results.