Can manuka (Leptospermum scoparium) antimicrobial properties be utilised in the remediation of pathogen contaminated land?

Prosser, J.A.; Anderson, Christopher; Horswell, Jacqui; Speir, T. W.

doi:10.1016/j.soilbio.2014.04.003

Cited by 14 publications

(18 citation statements)

References 48 publications

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“…Impressive effects of mānuka oil have been found against pathogenic bacteria associated with biosolid soil contamination, with significant growth inhibition of C. perfringens and L. monocytogenes [44]. The EC 50 = 0.07% and 23.3% (environmental effect concentration is the dose required to reduce pathogen growth by 50%) for C. perfringens and L. monocytogenes, respectively, on treatment with concentrated mānuka leaf extract for 24 h [44].…”

Section: Gram Positive Bacteriamentioning

confidence: 99%

“…Investigation of the growth inhibitory effect of an oil from mānuka seeds against Escherichia coli showed it to be ineffective according to while it was effective for Prosser et al (2014). Based on calorimetric growth experiments using E. coli K12 C600, showed that treatment with different doses of mānuka oil dissolved in Tween 80 (up to 4% v/v) had a dose-dependent effect in reducing bacterial growth but was not as effective as treatment with Melaleuca alternifolia oil [47].…”

Section: Gram Negative Bacteriamentioning

confidence: 99%

“…Based on calorimetric growth experiments using E. coli K12 C600, showed that treatment with different doses of mānuka oil dissolved in Tween 80 (up to 4% v/v) had a dose-dependent effect in reducing bacterial growth but was not as effective as treatment with Melaleuca alternifolia oil [47]. On the other hand, Prosser et al (2014) showed treatment with a very high dose of concentrated mānuka oil inhibited the growth of E. coli 0157 (EC 50 = 27.8%). Similar doses were required to inhibit the growth of Salmonella typhimurium.…”

Section: Gram Negative Bacteriamentioning

confidence: 99%

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Mānuka Oil—A Review of Antimicrobial and Other Medicinal Properties

et al. 2020

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Mānuka oil is an essential oil derived from Leptospermum scoparium, a plant that has been used by the indigenous populations of New Zealand and Australia for centuries. Both the extracted oil and its individual components have been associated with various medicinal properties. Given the rise in resistance to conventional antibiotics, natural products have been targeted for the development of antimicrobials with novel mechanism of action. This review aimed to collate available evidence on the antimicrobial, anti-parasitic and anti-inflammatory activities of mānuka oil and its components. A comprehensive literature search of was conducted using PubMed and Embase (via Scopus) targeting articles from database inception until June 2020. Chemical structures and IUPAC names were sourced from PubChem. Unpublished information from grey literature databases, Google search, targeted websites and Google Patents were also included. The present review found extensive in vitro data supporting the antimicrobial effects of mānuka oil warrants further clinical studies to establish its therapeutic potential. Clinical evidence on its efficacy, safety and dosing guidelines are necessary for its implementation for medical purposes. Further work on regulation, standardization and characterization of the medicinal properties of mānuka oil is required for establishing consistent efficacy of the product.

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Section: Gram Positive Bacteriamentioning

confidence: 99%

Section: Gram Negative Bacteriamentioning

confidence: 99%

Section: Gram Negative Bacteriamentioning

confidence: 99%

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Mānuka Oil—A Review of Antimicrobial and Other Medicinal Properties

et al. 2020

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“…The leaves, seeds and flowers of a variety of native Australian plants employed in biofilters, including Allocasuarina sp., Acacia sp., Melaleuca sp. and Leptospermum sp., are known to contain antimicrobial compounds such as terpenes, triketones and phenols [44–47]. Tissue extracts from these and other Australian native plants often demonstrate strong antimicrobial activity against faecal pathogens [44, 45, 48–50].…”

Section: Introductionmentioning

confidence: 99%

“…Antimicrobial vegetation represents an under-investigated biofilter design feature which may have significant pathogen inactivation potential [22]. Some independent antimicrobial susceptibility testing (AST) assays have been conducted on the exudates and tissue extracts of certain plant species that have been employed in biofilters [44–47]. However, only a single study to date has conducted antimicrobial testing on plants selected for their specific suitability in biofilters (seed exudates, seed and seedling extracts) against a single stormwater faecal microorganism ( E. coli ) [43].…”

Section: Introductionmentioning

confidence: 99%

Rise of the killer plants: investigating the antimicrobial activity of Australian plants to enhance biofilter-mediated pathogen removal

2019

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Background Biofilters are soil-plant based passive stormwater treatment systems which demonstrate promising, although inconsistent, removal of faecal microorganisms. Antimicrobial-producing plants represent a safe, inexpensive yet under-researched biofilter design component that may enhance treatment reliability. The mechanisms underlying plant-mediated microbial removal in biofilters have not been fully elucidated, particularly with respect to antimicrobial production. The aim of this study was therefore to inform biofilter vegetation selection guidelines for optimal pathogen treatment by conducting antimicrobial screening of biofilter-suitable plant species. This involved: (1) selecting native plants suitable for biofilters (17 species) in a Victorian context (southeast Australia); and (2) conducting antimicrobial susceptibility testing of selected plant methanolic extracts (≥ 5 biological replicates/species; 86 total) against reference stormwater faecal bacteria ( Salmonella enterica subsp. enterica ser. Typhimurium , Enterococcus faecalis and Escherichia coli ). Results The present study represents the first report on the inhibitory activity of polar alcoholic extracts from multiple tested species. Extracts of plants in the Myrtaceae family, reputed for their production of antimicrobial oils, demonstrated significantly lower minimum inhibitory concentrations (MICs) than non-myrtaceous candidates ( p < 0.0001). Melaleuca fulgens (median MIC: 8 mg/mL; range: [4–16 mg/mL]) , Callistemon viminalis (16 mg/mL, [2–16 mg/mL]) and Leptospermum lanigerum (8 mg/mL, [4–16 mg/mL]) exhibited the strongest inhibitory activity against the selected bacteria ( p < 0.05 compared to each tested non-myrtaceous candidate). In contrast, the Australian biofilter gold standard Carex appressa demonstrated eight-fold lower activity than the highest performer M. fulgens (64 mg/mL, [32–64 mg/mL]). Conclusion Our results suggest that myrtaceous plants, particularly M. fulgens , may be more effective than the current vegetation gold standard in mediating antibiosis and thus improving pathogen treatment within biofilters. Further investigation of these plants in biofilter contexts is recommended to refine biofilter vegetation selection guidelines. Electronic supplementary material The online version of this article (10.1186/s13036-019-0175-2) contains supplementary material, which is available to authorized users.

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Luminescent Microbial Bioassays and Microalgal Biosensors as Tools for Environmental Toxicity Evaluation

Hurtado-Gallego

Pulido-Reyes

González-Pleiter

et al. 2021

Handbook of Cell Biosensors

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This chapter deals with toxicity bioassays and biosensors based on luminescent microorganisms that report on global toxicity of a sample in such a way that luminescence is reduced or inhibited in the presence of toxic compounds that impair metabolism. Both natural and recombinant microorganisms are considered. A detailed description of their main characteristics and environmental applications is reported. Bioassays for detecting oxidative stress (both bioluminescent and fluorescent bioreporters) are also mentioned and discussed. Oxidative stress is caused by an unbalance between reactive oxygen species (ROS) and the Author contributed equally with all other contributors.

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Can manuka (Leptospermum scoparium) antimicrobial properties be utilised in the remediation of pathogen contaminated land?

Cited by 14 publications

References 48 publications

Mānuka Oil—A Review of Antimicrobial and Other Medicinal Properties

Mānuka Oil—A Review of Antimicrobial and Other Medicinal Properties

Rise of the killer plants: investigating the antimicrobial activity of Australian plants to enhance biofilter-mediated pathogen removal

Luminescent Microbial Bioassays and Microalgal Biosensors as Tools for Environmental Toxicity Evaluation

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