Background: Administrative staff, including principal investigators, administrative managers, and elected officials, have a crucial role in ensuring the ethical conduct of the clinical research that occurs in their organisations. However, only few studies have focused on their perspectives. Aim: This study describes the ethical aspects of clinical research from the perspectives of the administrative staff at university hospitals in Finland. Methods: Qualitative data were collected with semi-structured face-to-face interviews (n ¼ 31), and subjected to content analysis. Results: Four core perspectives emerged: human subject autonomy and its acknowledgement in clinical practice, increased tension between the regulations and practice of clinical research, concerns about a changing research environment, and factors that promote ethical research conduct in hospitals. Conclusion: Ethics always extends beyond the law. Therefore it is important to strengthen researchers' ethical sensitivity through education. Furthermore, we should reinforce elements such as organisational culture, cooperation, and a workable research infrastructure that support good research ethics in hospitals.