Can Laser-Ionisation Time-of-Flight Mass Spectrometry Be a Promising Alternative to Laser Ablation/Inductively-Coupled Plasma Mass Spectrometry and Glow Discharge Mass Spectrometry for the Elemental Analysis of Solids?

Сысоев, А. А.

doi:10.1255/ejms.494

Cited by 49 publications

(53 citation statements)

References 37 publications

(64 reference statements)

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“…in different mass spectrometers. [5][6][7][8][9][10][11] The isotopic abundance sensitivity, or abundance sensitivity, is usually expressed as the ratio of intensity (counts s 21 ) of the peak tail measured at mass m 2 1 (or m 1 1) to intensity (counts s 21 ) of the peak measured at mass m. 5,10,11 High isotopic abundance sensitivity is desirable for detecting a weak isotope peak directly adjacent to a strong neighboring peak.…”

Section: Introductionmentioning

confidence: 99%

“…5,12 This limitation can be partially overcome by operation of the quadrupole in higher stability regions 6 or by using a tandem quadrupole mass analyzer. 7 Another way of obtaining a high level of mass separation is by increasing the interaction time of ions with the filtering field, so that, in principle, all ions with incorrect m/z values must experience a sufficiently strong transverse acceleration and must be rejected.…”

Section: Introductionmentioning

confidence: 99%

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Improvement of abundance sensitivity in a quadrupole-based ICP-MS instrument with a hexapole collision cell

Boulyga¹,

Becker²

2002

J. Anal. At. Spectrom.

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High isotopic abundance sensitivity is desirable for the measurement of low-abundance isotopes in the presence of neighboring high-abundance isotopes. This is of interest when analyzing ultra low concentrations of trace elements or isotopes in the presence of elements or isotopes with much higher concentrations (e.g., radionuclides included in a matrix of stable isotopes). In this study, a quadrupole-based inductively coupled plasma mass spectrometer with a hexapole collision cell (ICP-CC-QMS), Platform ICP (Micromass UK), was used to study the improvement of abundance sensitivity using uranium and lutetium as examples. The median kinetic energy of 238 U 1 ions was about 1.2 eV and 0.9 eV when helium was introduced as a collision gas at flow rates of 5 ml min 21 and 10 ml min 21 , respectively. In the latter case, the proportion of ions with relatively high energy decreased significantly, which improved both the transmission of ions through the hexapole collision cell and mass selection by the quadrupole mass spectrometer. When introducing helium into the collision cell a reduction in peak tail of high-abundance isotopes by up to three orders of magnitude, depending on the mass analyzed, was observed. The abundance sensitivity for 236 U/ 238 U isotope ratio was improved from 2.3 6 10 25 to 6.3 6 10 28 . Abundance sensitivities as low as 3.5 6 10 28 , 6.6 6 10 28 and 2.0 6 10 28 were achieved at masses m 2 2.5 u, m 2 1.5 u and m 1 2.5 u (m~174.94 u for 175 Lu), respectively. Reducing the kinetic energy also improved the mass resolution by about 10%. However, increasing the mass resolution of the quadrupole instrument had a significantly lower influence on abundance sensitivity than reducing the ion energy by collision with helium atoms. The present study of the effect of the pressurized ion guide on abundance sensitivity was limited to some extent because of the relatively high background count rate of the Daly-type ion detector in the ICP-CC-QMS system. An ion detector possessing a low background would be desirable for further studies. Improved abundance sensitivity can be useful in analyzing long-lived radionuclides like 236 U and 129 I in the presence of high-abundance stable isotopes like 238 U and 127 I.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Improvement of abundance sensitivity in a quadrupole-based ICP-MS instrument with a hexapole collision cell

Boulyga¹,

Becker²

2002

J. Anal. At. Spectrom.

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“…The laser beam waist and profile can be adjusted to the required lateral resolution (mm) and sampling depth ($100 nm), respectively. Therefore, this sampling strategy has been used in spectroscopy and in combination with different secondary ionization sources, which include Laser Induced Breakdown Spectroscopy (LIBS) (Rusak et al, 1998), LA-MS (Sysoev & Sysoev, 2002), LA-ICP-OES (Kanický, Otruba, & Mermet, 2000), and LA-ICP-MS (Hattendorf, Latkoczy, & Günther, 2003), respectively.…”

Section: Analytical Performance Of Laser Ablation (La) Techniquesmentioning

confidence: 99%

“…The transient ion signals generated during the laser ablation process are well-suited for solid-material characterization when coupled to a fast multi-element TOF mass analyzer. For instance, the capability of TOF-MS to analyze charged particles from laser plasmas has been discussed by several authors (VanVaeck et al, 1994;Ledingham & Singhal, 1997;Sysoev & Sysoev, 2002;Hang, 2005). Moreover, the application of LA-TOF-MS for depth profile analysis of different coated samples has been investigated, and highlight the analysis of multilayers (TiN/TiAlN) on Fe and the analysis of silicon wafers coated with alternating Cr and Ni layers (NIST 2135c) (Margetic et al, 2001;Margetic, Niemax, & Hergenröder, 2003).…”

Section: Analytical Performance Of Laser Ablation (La) Techniquesmentioning

confidence: 99%

Femtosecond laser ablation inductively coupled plasma mass spectrometry: Fundamentals and capabilities for depth profiling analysis

Pisonero

Günther

2008

Mass Spectrometry Reviews

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Laser ablation coupled to inductively coupled plasma mass spectrometry has become a versatile and powerful analytical method for direct solid analysis. The applicability has been demonstrated on a wide variety of samples, where major, minor, and trace element concentrations or isotope ratio determinations have been of interest. The pros and cons of UV-nsec laser ablation have been studied in detail, and indicate that aerosol generation, aerosol transport, and aerosol excitation-ionization within the ICP contribute to fractionation effects, which prevent this method from a more universal application to all matrices and all elements. Recent progresses in IR-fs and UV-fs laser ablation coupled to ICP-MS have been reported, which increase the inter-matrix and multi-element quantification capabilities of this method. These fundamental improvements in LA-ICP-MS are of significant importance for entering new applications in material science and related research fields. In particular, because coatings (conducting and non-conducting) consist of single or multilayers of various elemental composition and of different thickness (nm-mm range), significant progress in the field of depth profiling with fs-laser ablation can be expected. Therefore, in-depth profile analysis of polymers, semiconductors, and metal sample investigations, using ultra-fast laser ablation for sampling and the currently achievable figures of merit, are discussed. In this review manuscript, the enhanced capabilities of fs-LA-ICP-MS for direct solid sampling are highlighted, and it is discussed about current methods used for quantitative analysis and depth profiling, the ablation process of UV-ns and UV-fs, the influence of the laser beam profile, aerosol structure and transport efficiency, as well as the influence of the ICP-MS (e.g., vaporization and ionization efficiency in the plasma, and type of mass analyzer).

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“…The first proposal based on such a spiral trajectory was put forward by Bakker et al [15,16]. Sysoev and coworkers calculated and constructed ion optics using only one electrostatic sector with an ion deflection angle of 509° [17,18] so that ions travel for approximately 1.5 cycles along a helical ion trajectory. Matsuda also proposed two types of TOF mass spectrometers [19], a corkscrew type and a mosquito-coil type.…”

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confidence: 99%

The design and characteristic features of a new time-of-flight mass spectrometer with a spiral ion trajectory

Satoh

Tsuno

Iwanaga

et al. 2005

J. Am. Soc. Mass Spectrom.

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A new time-of-flight (TOF) mass spectrometer with a corkscrew ion trajectory was designed and constructed. The spiral trajectory was realized by using four toroidal electrostatic sectors. Each had fifteen-stories made of sixteen Matsuda plates piled up inside a cylindrical electrostatic sector. The ions passed the four toroidal electrostatic sectors sequentially and revolved along a figure-eight-shaped orbit on a certain projection plane. During the multiple revolutions, each ion trajectory was shifted by 50 mm per cycle on a direction perpendicular to the projection plane, thus generating a spiral trajectory. The flight path length of one cycle was 1.308 m so that the maximum flight path length became ϳ20 m. The mass resolution, mass accuracy, and ion transmission were tested by utilizing an orthogonally coupled electron ionization source. A mass resolution of 35,000 (FWHM) for m/z greater than 300 was achieved. Even in a lower mass region, mass resolutions of more than 20,000 (FWHM) were confirmed with a doublet of 12 C 5 1 H 5 14 N ϩ and 13 C 12 C 5 1 H 6 ϩ . The mass accuracy was also improved such that it was better than 1 ppm with only one internal standard peak. . With the advent of matrix-assisted laser desorption/ionization (MALDI) [3,4] and electrospray ionization (ESI) techniques [5], the TOF mass spectrometer has become a powerful analytical tool, especially in biochemistry and biotechnology. Its characteristic features are high sensitivity, theoretically infinite massrange, and rapid measurements. It also provides a simple and easy method to obtain exact mass measurements. These features give the TOF mass spectrometer a great advantage over other mass spectrometers, such as the quadrupole, ion trap, and magnetic sector-type mass spectrometers. However, a drawback of the TOF mass spectrometer is the intrinsic characteristic of poor mass resolving power for accurate mass analysis, especially for small molecules, compared with a Fourier-transform ion cyclotron resonance (FT-ICR) mass spectrometer. In an orthogonal acceleration (oa-) TOF mass spectrometer, the mass resolution and mass accuracy are limited to approximately 10,000 (FWHM) and 3 ppm, respectively. On the other hand, in the FT-ICR mass spectrometer, they have reached over 100,000 (FWHM) and 1 ppm, respectively.The mass resolution of the TOF mass spectrometer is expressed as R ϭ m/⌬m ϭ t/2⌬t, where t is the total time of flight, which is given by the flight path length divided by the ion velocity, and ⌬t is the peak width measured at FWHM. Thus, it is essential to extend the flight path length and minimize the peak width to improve the mass resolution. The peak width depends on the broadening of the ion packet at the detector, especially along the velocity axis and the response time of the detector. Various ion optical techniques have been reported to minimize the peak width: space focusing [6], time-lag focusing [6], orthogonal acceleration [7], and an ion mirror [8] or sector fields [9]. The mass accuracy can be steadily improved by increas...

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Can Laser-Ionisation Time-of-Flight Mass Spectrometry Be a Promising Alternative to Laser Ablation/Inductively-Coupled Plasma Mass Spectrometry and Glow Discharge Mass Spectrometry for the Elemental Analysis of Solids?

Cited by 49 publications

References 37 publications

Improvement of abundance sensitivity in a quadrupole-based ICP-MS instrument with a hexapole collision cell

Improvement of abundance sensitivity in a quadrupole-based ICP-MS instrument with a hexapole collision cell

Femtosecond laser ablation inductively coupled plasma mass spectrometry: Fundamentals and capabilities for depth profiling analysis

The design and characteristic features of a new time-of-flight mass spectrometer with a spiral ion trajectory

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