Can laboratory findings predict pulmonary involvement in children with COVID‐19 infection?

Böncüoğlu, Elif; Coşkun, Mehmet; Kıymet, Elif; Atasoy, Tülay Öztürk; Şahinkaya, Şahika; Cem, Ela; Düzgöl, Mine; Çelebi, Miray Yılmaz; Kara, Aybüke Akaslan; Arıkan, Kamile; Bayram, Nuri; Devrim, İlker

doi:10.1002/ppul.25452

Cited by 7 publications

(4 citation statements)

References 27 publications

(47 reference statements)

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“…In our study, this rate was found to be 14%. In a pediatric study conducted in our country, Boncuoglu et al abnormal CT findings and elevated CRP have been shown to accompany patients [25]. In our study, the number of patients with abnormal CT results were statistically insignificant.…”

Section: (Which Was Not Certified By Peer Review)contrasting

confidence: 52%

Covid-19 Disease in Pediatric Emergency Room: The Dilemma of Cycle Threshold Value

Timur

Demirpek

Demirbaş

et al. 2022

Preprint

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BACKGROUND: The havoc of this SARS-CoV-2 pandemic was being distributed unequally. Children, of all ages, and in all countries, are being affected. Testing for infection with SARS-CoV-2, helps to determine what interventions may need to be put in place to control the spread of disease within a community. A PCR test for COVID-19 is a test used to diagnose children infected with SARS-CoV-2, the virus that causes COVID-19. Cycle threshold (Ct) is a semi-quantitative value that tells us approximately how much viral genetic material is in the sample following testing by RT-PCR. Our aim was to evaluate how RT-PCR Ct values among children with confirmed SARS-CoV-2 compared with clinical, laboratory and demographic data. MATERIALS AND METHODS: In the study, demographic, laboratory, radiological and clinical characteristics and the effect of Ct value of patients with positive Covid-19 PCR test who applied to the Emergency Pediatric Service with the suspicion of infectious disease between May 3,2020 and August 3, 2020 were retrospectively examined. RESULTS: There was no statistical significance between the patient's hospitalization status, admission symptoms other than fever, and laboratory parameters and the mean Ct value. It was determined that the mean Ct value of the patients who had symptoms at the time of admission to the hospital was statistically significantly lower. CONCLUSION: In this study, symptomatic patients had lower Ct than asymptomatic patients; this reflects the clinical impact of increased viral load. In our study, the low Ct values in symptomatic patients and higher values in asymptomatic patients; reflects the importance of the effect on the clinic with the increase of viral load. In evidence-based medicine practices, it will be useful to check the compatibility of complaints and findings with laboratory data while evaluating patients. In addition, if the patient is symptomatic and has a high ct value, co-infections should be considered. Keywords: Children, COVID-19, Cycle Threshold, RT-PCR, pandemic

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Section: (Which Was Not Certified By Peer Review)contrasting

confidence: 52%

Covid-19 Disease in Pediatric Emergency Room: The Dilemma of Cycle Threshold Value

Timur

Demirpek

Demirbaş

et al. 2022

Preprint

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“…In a previous Turkish pediatric study, Böncüoğlu et al found that abnormal CT findings correlated with elevated CRP levels. 27 In our study, the number of patients with abnormal CT results was too small to draw any conclusions.…”

Section: Discussionmentioning

confidence: 70%

Coronavirus Disease 2019 in Pediatric Emergency Room: The Dilemma of Cycle Threshold Value

Timur¹,

Demirpek²,

Demirbaş

et al. 2022

J Pediatr Infect Dis

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Objective The havoc caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic could not have been predicted, with children being affected worldwide. Testing for SARS-CoV-2 infection helped to define the interventions against the spread of the disease. A polymerase chain reaction (PCR) test has been the mainstay of diagnostic testing. Cycle threshold (Ct) is a semiquantitative value that indicates approximately how much viral genetic material was in the sample. The aim of this study was to evaluate the impact of Ct values among children with SARS-CoV-2 infection. Methods Between May 3, 2020 and August 3, 2020, clinical laboratory input and the data of patients with positive SARS-CoV-2 PCR tests were retrospectively studied. Results There was no statistical significance between Ct values and the patient's status, symptoms other than fever, or other laboratory findings. However, the Ct value of patients who had symptoms at the time of admission to the hospital was significantly lower. Conclusion In this study, symptomatic patients had lower Ct than asymptomatic patients that reflected higher viral loads. In evidence-based medicine applications, it might be useful to correlate the clinical history with laboratory test results. Even symptomatic patients with high Ct value coinfections, or an alternative acute infection, should be considered.

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“…Despite all ages were affected, Kara et al reported that an association between increased age and worse outcomes in their study, in addition to previous studies indicating that younger age has no protective effect on preventing SARS-CoV-2 infection from developing COVID-19 pneumonia in children[18] [19]. In addition Böncüoğlu et al, reported that the mean age was not dfferent at children with or without pulmonary involvement con rmed by CT scan [20].…”

Section: Discussionmentioning

confidence: 74%

A comparison of the characteristics and outcomes of children with COVID-19 infections and children with other respiratory tract viral infections requiring high-flow nasal cannula

Besin,

Böncüoğlu,

Kıymet

et al. 2023

Preprint

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Background The aim of this single-center retrospective cohort study was to compare the clinical and laboratory differences, response, and outome of the patients requiring HFNC between two distinct groups, children with SARS-CoV-2 infection and children infected with other types of respiratory tract viruses during the COVID-19 pandemic. Methods This single-center cross-sectional study was conducted in the Pediatric Infectious Disease Ward and COVID-19 pademic wardç Data of the patients was collected from medical records including information on demographic characteristics (age, gender, and medical history); underlying diseases or co-morbidities, indications for HFNC and physical examination findings. If present laboratory examinations taken from the submissions were recorded. The indication and duration of HFNC, the length of hospital stay, admission or transfer to the PICU each patient’s stay in the hospital and if present the mortality rates by group were recorded.. Results During the study period a total of 171 patients were followed-up under HFNC. Among them, 8 patients were excluded from the study due to absence of arterial blood gas results before HFNC and 6 patients were excluded due to absence of PCR testing for COVID-19. At the final analysis, 157 patients under HFNC treatment were included including 22 COVID-19 PCR positive (group I ) and 135 COVID-19 PCR negative patients(Group II). Conclusions This study, patients with COVID-19 infections had longer durations of HFNC and hospital stay, in addition to high rate of transmission to PICU, suggesting a worser clinical outcome compared to infections with other viruses.

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Can laboratory findings predict pulmonary involvement in children with COVID‐19 infection?

Cited by 7 publications

References 27 publications

Covid-19 Disease in Pediatric Emergency Room: The Dilemma of Cycle Threshold Value

Covid-19 Disease in Pediatric Emergency Room: The Dilemma of Cycle Threshold Value

Coronavirus Disease 2019 in Pediatric Emergency Room: The Dilemma of Cycle Threshold Value

A comparison of the characteristics and outcomes of children with COVID-19 infections and children with other respiratory tract viral infections requiring high-flow nasal cannula

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