Can Ischemia-Modified Albumin Be Used as an Objective Biomarker for Renal Ischemic Damage? An Experimental Study With Wistar Albino Rats

Koçan, Hüseyin; Çitgez, Sinharib; Yücetaş, Uğur; Yücetaş, Esma; Yazıcı, Mesut; Amasyalı, Akın S.; Ünlüer, Erol Erden; Tasci, Ayşe

doi:10.1016/j.transproceed.2014.11.001

Cited by 10 publications

(8 citation statements)

References 21 publications

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“…IMA in rats, although suggested not to be equal to the human counterpart, has been reported to be useful in various studies (24, 25). In previous rat models, IMA was reported not to be signifi cant in acute mesentery ischemia, but it has been suggested that it could be used in ovarian torsion and renal ischemic damage as a non-selective biomarker (26)(27)(28). IMA has been demonstrated to be increased in cerebral ischemia (18).…”

Section: Discussionmentioning

confidence: 99%

Role of ischemic modified albumin in the early diagnosis of increased intracranial pressure and brain death

Kara¹,

Pampal²,

Yıldırım³

et al. 2017

BLL

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AIM: Increased intracranial pressure following trauma and subsequent possible development of brain death are important factors for morbidity and mortality due to ischemic changes. We aimed to establish the role of ischemic modifi ed albumin (IMA) in the early diagnosis of the process, starting with increased intracranial pressure and ending with brain death. MATERIALS AND METHODS: Eighteen Wistar-Albino rats were divided into three groups; control (CG, n = 6), increased intracranial pressure (ICPG, n = 6), and brain death (BDG, n = 6). Intracranial pressure elevation and brain death were constituted with the infl ation of a balloon of a Fogarty catheter in the epidural space. In all three groups, blood samples were drawn before the procedure, and at minutes 150 and 240 for IMA and malondialdehyde (MDA) analysis. RESULTS: Serum IMA levels at 150 and 240 minutes were higher in ICPG than in CG (p < 0.05). IMA levels were similar in ICPG and BDG. Serum MDA levels at 150 and 240 minutes increased in ICPG and BDG groups compared to CG (p < 0.05). MDA levels were similar in ICP and BD groups. CONCLUSION: IMA should be considered as a biochemical parameter in the process starting from increased intracranial pressure elevation and ending at brain death (Tab. 3, Fig. 5, Ref. 31). Text in PDF www.elis.sk. KEY WORDS: ischemic modifi ed albumin, increased intracranial pressure, brain death.

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Section: Discussionmentioning

confidence: 99%

Role of ischemic modified albumin in the early diagnosis of increased intracranial pressure and brain death

Kara¹,

Pampal²,

Yıldırım³

et al. 2017

BLL

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“…It is a nonspecific biomarker that can be measured in a short time after ischemic injury (131). Studies have been shown to be used after renal ischemic injury (132,133). Although not alone, it can be used with other biomarkers in the diagnosis of AKI.…”

Section: Biomarkers With Non-renal Originmentioning

confidence: 99%

Biomarkers of acute kidney injury and their role in clinical patient management

et al. 2020

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Acute kidney injury (AKI) is a common public health problem and has a significant impact on cardiovascular disease, mortality and increased hospital costs. Also, AKI can progress to chronic kidney disease (CKD). Therefore, early diagnosis is very important for AKI. Serum creatinine (SCr) is a well-known biomarker in the diagnosis of AKI. However, changes in SCr levels are insufficient in early diagnosis so, new biomarkers are needed. Because of that, the search for biomarkers for the early detection of AKI is an ongoing process. In recent years, early diagnosis, prognostic and predictive biomarkers have been discovered to replace or support SCr in the diagnosis of AKI. New biomarkers can help early diagnosis and effective management of AKI. Since there are many biomarkers, when and under which condition these biomarkers should be used cause confusion. In this review, we aimed to construct and ease to use classification of these AKI biomarkers and summarize the current literature. We have divided the biomarkers into two main categories: renal and non-renal origin. Then, we have classified the biomarkers of renal origin as glomerular, tubular and unknown renal site. We have also described the clinical use of these biomarkers for diagnosis and prognosis.

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“…They found that IMA levels in group 3 were significantly higher than those in the other groups and stated that IMA levels could be used as a biomarker to demonstrate tissue damage in diabetic patients in the future (Gulpamuk et al, 2018). Based on the results of their experiments, it was reported that renal injury and IMA level increased significantly as the duration of renal ischaemia increased, and it was stated that IMA levels could be used as a nonspecific biomarker to demonstrate renal ischaemic injury (Kocan et al, 2014). In the experimental study conducted on Wistar albino rats, sham, 10-min renal ischaemia, 20-min renal ischaemia, 30-min renal ischaemia and 40-min renal ischaemia groups were formed.…”

Section: Xue Et Al Investigated the Effect Of Gradual Low-flow Repermentioning

confidence: 99%

“…In the experimental study conducted on Wistar albino rats, sham, 10-min renal ischaemia, 20-min renal ischaemia, 30-min renal ischaemia and 40-min renal ischaemia groups were formed. Based on the results of their experiments, it was reported that renal injury and IMA level increased significantly as the duration of renal ischaemia increased, and it was stated that IMA levels could be used as a nonspecific biomarker to demonstrate renal ischaemic injury (Kocan et al, 2014).…”

Section: Xue Et Al Investigated the Effect Of Gradual Low-flow Repermentioning

confidence: 99%

Predictive value of ischaemia‐modified albumin in spermatogenesis in an experimental testicular torsion model

et al. 2019

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Our aim was to measure the ability of ischaemia-modified albumin (IMA) to predict testicular histopathological damage in the testes of rats with short-and long-term ischaemia using experimental testicular torsion and subsequent reperfusion via detorsion.21 Wistar Albino rats were randomized into three groups. The sham group was subjected to a mid-scrotal incision only. The 4-and 8-hr T/D (Torsion/Detorsion) groups were subjected to left testicular torsion by twisting the testes by 720 degrees counterclockwise. 2 cc venous blood samples were taken from the sham group after the mid-scrotal incision, and from the 4-and 8-hr T/D groups after 4 and 8 hr respectively. After that, the 4-and 8-hr T/D groups were subjected to detorsion.Two days later, orchiectomy was performed. Ischaemia-modified albumin levels were significantly different among the groups at 48 hr prior to orchiectomy (reperfusion; p = .003). Based on the results of the paired comparisons, it was found that IMA levels of the sham group were significantly higher than those of the 4-and 8-hr T/D groups (p = .002 and .009 respectively). Our study has showed that IMA may be used to predict ischaemia/reperfusion injury, which is another complication that may occur following detorsion in testicular torsion. K E Y W O R D Sexperimental testicular torsion, ischaemia, ischaemia-modified albumin, rats, reperfusion, spermatogenesis

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Can Ischemia-Modified Albumin Be Used as an Objective Biomarker for Renal Ischemic Damage? An Experimental Study With Wistar Albino Rats

Cited by 10 publications

References 21 publications

Role of ischemic modified albumin in the early diagnosis of increased intracranial pressure and brain death

Role of ischemic modified albumin in the early diagnosis of increased intracranial pressure and brain death

Biomarkers of acute kidney injury and their role in clinical patient management

Predictive value of ischaemia‐modified albumin in spermatogenesis in an experimental testicular torsion model

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