“…In general, however, control procedures in these studies leave much to be desired, and doseresponse information is seldom given. Dispensa and Hornbeck (40,41) studied maze learning effects in offspring of chemical douching of the mother and endocrine therapy of the father, but their work had many of the shortcomings of other early drug-behavior studies. Of the earlier studies, Wentink's work (193) on the effect of various drugs and hormones on a stable food-rewarded bar-pressing response {insulin and Benzedrine markedly increasing the rate, but sodium bromide, ephedrine and phenobarbital having little effect) probably represents the closest approach to recent developments, but it too lacked many of the necessary behavioral and pharmacological refinements.…”