Can infants be protected by means of maternal vaccination?

Esposito, Susanna; Bosis, Samantha; Morlacchi, Laura; Baggi, Elena; Sabatini, C; Principi, Nicola

doi:10.1111/j.1469-0691.2012.03936.x

Cited by 34 publications

(27 citation statements)

References 63 publications

(94 reference statements)

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“…We have previously demonstrated that maternal immunization may represent an alternative strategy for protecting the neonate against pertussis (44). However, so far the focus of maternal immunization studies has been on the induction of antibodies (14). Here, in addition to maternal antibodies, we further examined the role of maternal cytokines following immunization.…”

Section: Discussionmentioning

confidence: 99%

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Protective Role of Passively Transferred Maternal Cytokines against Bordetella pertussis Infection in Newborn Piglets

et al. 2017

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Maternal vaccination represents a potential strategy to protect both the mother and the offspring against life-threatening infections. This protective role has mainly been associated with antibodies, but the role of cell-mediated immunity, in particular passively transferred cytokines, is not well understood. Here, using a pertussis model, we have demonstrated that immunization of pregnant sows with heat-inactivated bacteria leads to induction of a wide range of cytokines (e.g., tumor necrosis factor alpha [TNF-␣], gamma interferon [IFN-␥], interleukin-6 [IL-6], IL-8, and IL-12/IL-23p40) in addition to pertussis-specific antibodies. These cytokines can be detected in the sera and colostrum/milk of vaccinated sows and subsequently were detected at significant levels in the serum and bronchoalveolar lavage fluid of piglets born to vaccinated sows together with pertussis-specific antibodies. In contrast, active vaccination of newborn piglets with heat-inactivated bacteria induced high levels of specific IgG and IgA but no cytokines. Although the levels of antibodies in vaccinated piglets were comparable to those of passively transferred antibodies, no protection against Bordetella pertussis infection was observed. Thus, our results demonstrate that a combination of passively transferred cytokines and antibodies is crucial for disease protection. The presence of passively transferred cytokines/antibodies influences the cytokine secretion ability of splenocytes in the neonate, which provides novel evidence that maternal immunization can influence the newborn's cytokine milieu and may impact immune cell differentiation (e.g., Th1/Th2 phenotype). Therefore, these maternally derived cytokines may play an essential role both as mediators of early defense against infections and possibly as modulators of the immune repertoire of the offspring.

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Section: Discussionmentioning

confidence: 99%

“…Vaccination with TT induces a specific antibody response that is transported across the placenta with 100% efficiency and provides protection against neonatal tetanus (12,13). In addition, vaccinations against Haemophilus influenzae type b and pneumococcal infections are other examples of success in maternal immunization strategies (14).…”

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confidence: 99%

Protective Role of Passively Transferred Maternal Cytokines against Bordetella pertussis Infection in Newborn Piglets

et al. 2017

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“…La vacunación de las mujeres gestantes es actualmente una forma de prevención de una amplia variedad de enfermedades como el tétanos, tos ferina, difteria, infecciones por neumococo, meningococo, rotavirus, virus del papiloma humano, Haemophilus influenzae tipo b y el herpes zóster (37,38). Sin embargo, en cuanto al SGB, el beneficio de una vacuna comparado con la profilaxis con antibióticos sería que podría prevenir la infección de inicio tardío y no conlleva el riesgo de aumentar la resistencia bacteriana.…”

Section: Vacunaciónunclassified

Prevención de la infección por Streptococcus del grupo B en gestantes

Sánchez

Arango

Díaz

et al. 2017

MedUNAB

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ResumenIntroducción: La infección neonatal por Streptococcus del Grupo B en mujeres gestantes es un problema creciente a nivel mundial y tiene múltiples consecuencias para el recién nacido, su prevención impacta directamente la morbimortalidad neonatal. Objetivo: Brindar al lector información relevante sobre la importancia clínica, nuevos métodos de tamizaje y formas de prevención de la infección por Streptococcus del Grupo B en gestantes, que será de utilidad para evitar complicaciones del binomio materno-fetal. Metodología: En esta revisión de la literatura, se estudiaron 53 artículos, abordando evidencia tanto en el ámbito local e internacional, utilizando las bases de datos PubMed, ScienceDirect y Google Scholar, dentro los criterios de búsqueda se tuvo en cuenta el año de publicación, incluyendo artículos que fueron publicados a partir del año 2011. Resultados: La comunidad internacional ha desarrollado guías y planes de prevención; en la actualidad, para una profilaxis y prevención adecuada se proponen diversos métodos, partiendo del tamizaje para las maternas, uso de antibióticos durante el embarazo y parto, además del desarrollo de vacunas maternas para prevenir infecciones. Conclusiones: La colonización por Streptococcus del Grupo B en gestantes y el riesgo que conlleva para el recién nacido y su madre, exige una constante actualización en técnicas de tamizaje, prevención y manejo. Numerosos avances en estos campos vienen llevándose a cabo en los últimos años y su fortalecimiento y desarrollo será clave para impactar positivamente la morbi-mortalidad materno-fetal. Abstract Introduction:The neonatal infection by Group B Streptococcus in pregnant women is a growing problem worldwide and has multiple consequences for the newborn, so its prevention directly impacts neonatal morbimortality. Objective: To provide the reader with relevant information about the clinical importance, new screening methods and ways to prevent Group B Streptococcus infection in pregnant women which will be useful to avoid complications in the pairing of maternal-fetal. Methodology: In this review of literature, 53 articles were studied addressing local and international evidence by using PubMed, ScienceDirect and Google Scholar databases; within the search criteria the year of publication was taken into account to do so, thus articles published from 2011 were included. Results: The international community has developed guidelines and prevention plans for this infection. Currently, for an adequate prophylaxis and prevention, various methods are proposed such as the screening for expectant mothers, the use of antibiotics during pregnancy and childbirth, and the development of maternal immunization to prevent infections as well. Conclusions: The colonization by Group B Streptococcus in pregnant women and the risk that this entails to the newborn and his/her mother requires constant updating in techniques for screening, prevention and management of it. Numerous advances in these fields of study have been carried out in recent years, ...

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“…123 Multiple vaccines were examined with regards to their appropriateness for maternal vaccination, including the influenza, pneumococcal, dTp, HPV, MMR, V, meningococcal, HAV and HBV vaccines. Of these vaccines, LAIV, MMR, and V are contraindicated for pregnant women, whereas HPV is not recommended for pregnant women.…”

Section: Vaccination Of Pregnant Womenmentioning

confidence: 99%

Recommended immunization schedules for adults: Clinical practice guidelines by the Escmid Vaccine Study Group (EVASG), European Geriatric Medicine Society (EUGMS) and the World Association for Infectious Diseases and Immunological Disorders (WAidid)

Esposito

Bonanni

Maggi

et al. 2016

Human Vaccines & Immunotherapeutics

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Rapid population aging has become a major challenge in the industrialized world and progressive aging is a key reason for making improvement in vaccination a cornerstone of public health strategy. An increase in age-related disorders and conditions is likely to be seen in the near future, and these are risk factors for the occurrence of a number of vaccine-preventable diseases. An improvement in infectious diseases prevention specifically aimed at adults and the elderly can therefore also decrease the burden of these chronic conditions by reducing morbidity, disability, hospital admissions, health costs, mortality rates and, perhaps most importantly, by improving the quality of life. Among adults, it is necessary to identify groups at increased risk of vaccine-preventable diseases and highlight the epidemiological impact and benefits of vaccinations using an evidence-based approach. This document provides clinical practice guidance on immunization for adults in order to provide recommendations for decision makers and healthcare workers in Europe. Although immunization is considered one of the most impactful and cost-effective public health measures that can be undertaken, vaccination coverage rates among adults are largely lower than the stated goal of 95% among adults, and stronger efforts are needed to increase coverage in this population. Active surveillance of adult vaccine-preventable diseases, determining the effectiveness of the vaccines approved for marketing in the last 5 y, the efficacy and safety of vaccines in immunocompromised patients, as well as in pregnant women, represent the priorities for future research.

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Can infants be protected by means of maternal vaccination?

Cited by 34 publications

References 63 publications

Protective Role of Passively Transferred Maternal Cytokines against Bordetella pertussis Infection in Newborn Piglets

Protective Role of Passively Transferred Maternal Cytokines against Bordetella pertussis Infection in Newborn Piglets

Prevención de la infección por Streptococcus del grupo B en gestantes

Recommended immunization schedules for adults: Clinical practice guidelines by the Escmid Vaccine Study Group (EVASG), European Geriatric Medicine Society (EUGMS) and the World Association for Infectious Diseases and Immunological Disorders (WAidid)

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