Can Individualized-Targeted Computerized Cognitive Training Benefit Adults with HIV-Associated Neurocognitive Disorder? The Training on Purpose Study (TOPS)

Vance, David E.; Fazeli, Pariya L; Azuero, Andres; Wadley, Virginia G.; Raper, James L.; Ball, Karlene

doi:10.1007/s10461-021-03230-y

Cited by 15 publications

(36 citation statements)

References 32 publications

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“…Of those, 1019 records were excluded based on titles and abstracts, and 24 full-text articles were assessed for eligibility. After exclusions, 12 eligible RCTs [40][41][42][44][45][46][47][48][49][54][55][56] were selected for inclusion in the meta-analysis.…”

Section: Search Resultsmentioning

confidence: 99%

“…Among 9 studies 40,41,[44][45][46][47]49,54,56 involving 376 participants, the SMD for attention/working memory was 0.62 (95% CI, 0.33-0.91; P < .001). Moderate heterogeneity was detected (Q = 14.04; I 2 = 43%; P = .08).…”

Section: Attention/working Memorymentioning

confidence: 99%

“…56 Training frequency ranged from 2 sessions per week 41,42,46 to 4 sessions per week, 48 total number of training hours ranged from 1.7 54 to 20.0, 55,56 and time since training ranged from 3 weeks 54 to 24 weeks. 45 Although all 12 studies [40][41][42][44][45][46][47][48][49][54][55][56] used CCT programs, the intervention tools were different. Cody et al, 41 Fazeli et al, 49 and Pope et al 48 used the same cognitive training program (BrainHQ.com; Posit Science) along with transcranial direct current stimulation (tDCS).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Six studies 44,45,48,49,54,56 reported outcomes for the abstraction/executive function domain, 9 studies 40,41,[44][45][46][47]49,54,56 for the attention/working memory domain, 5 studies 41,42,49,54,56 for the memory domain, 5 studies 42,45,49,54,56 for the motor skills domain, 5 studies 41,42,44,47,54 for the speed of information processing domain, 3 studies 44,45,55 for the daily function domain, 1 study 56 for the sensory/perceptual skills domain, and 4 studies 42,45,47,49 for the verbal/language skills domain. Abstraction/Executive Function Among 6 studies 44,45,48,49,54,56 including 240 participants, the SMD for abstraction/executive function was 0.58 (95% CI, 0.26-0.91; P < .001). No significant heterogeneity (Q = 7.11; I 2 = 30%; P = .21) or publication bias (intercept, −0.70; 95% CI, −5.92 to 4.52; P = .73) was found.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…One study 56 comprising 88 participants examined sensory/perceptual skills. The SMD was 0.06 (95% CI, −0.36 to 0.48; P = .78).…”

Section: Sensory/perceptual Skillsmentioning

confidence: 99%

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Evaluation of Computerized Cognitive Training and Cognitive and Daily Function in Patients Living With HIV

Wei

Hou

et al. 2022

JAMA Netw Open

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IMPORTANCEIn the era of antiretroviral therapy (ART), the incidence of HIV-associated neurocognitive disorder (HAND) has not yet been controlled. With the exception of ART, there is no beneficial pharmacologic treatment. However, some studies have reported that computerized cognitive training (CCT) programs may improve cognitive function among people living with HIV. OBJECTIVE To examine the association between CCT programs and 8 domains measuring cognitive function (7 domains) and daily function (1 domain) among people living with HIV.

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