Can <i>Glycyrrhiza glabra</i> L. reduce both upper gastrointestinal tract bleeding and ventilator‐associated pneumonia in intensive‐care unit patients?

Firouzian, Abolfazl; Darvishi‐Khezri, Hadi

doi:10.1111/fct.12198

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…demonstrated that the use of licorice extract could prevent the occurrence of gastrointestinal bleeding and ventilator-associated pneumonia. These effects are attributed to the antibacterial, anti-reflux, and anti-inflammatory properties of the extract in patients who have endotracheal tubes and are hospitalized in the intensive care unit [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…Although licorice has been proposed as an alternative option for chlorhexidine in the treatment of gum infections, its effect on the oral health of patients with endotracheal tubes and a reduced level of consciousness in ICUs has not been investigated [ 15 , 19 ]. On the other hand, replacing chlorhexidine with an herbal product with low side effects and low cost can lead to reduced complications and treatment costs and increased patient satisfaction [ 18 ]. Therefore, the research question is whether licorice mouthwash, which is an herbal product, can be used as a suitable alternative to chlorhexidine mouthwash for improving the oral health of patients with endotracheal tubes in ICUs.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the effect of licorice and chlorhexidine mouthwash on the oral health of intubated patients in the intensive care unit

Oshvandi,

Lotfi,

Azizi

et al. 2024

BMC Oral Health

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Background Chlorhexidine mouthwash is a common oral hygiene product used in intensive care units, but it may have some adverse effects. Licorice, a natural herb, could be a potential alternative to chlorhexidine. However, the effect of licorice mouthwash on the oral health of intubated patients has not been studied yet. Therefore, this study aimed to compare the effects of licorice and chlorhexidine mouthwash on the oral health of intubated patients. Methods This was a triple-blind clinical trial. The sample included 130 intubated patients admitted to an intensive care unit in Iran. The samples were selected by convenience sampling and randomly assigned to two groups: A and B. In group A, the main researcher applied 15 ml of 0.2% chlorhexidine mouthwash after each brushing (twice a day for 5.5 days) and suctioned it after 30 s. In group B, 20% licorice mouthwash was used instead of chlorhexidine. The demographic information questionnaire and the Beck Oral Assessment Scale (BOAS) were completed by one of the nurses before and on the sixth day of the study. Results Finally, 60 patients in each group completed the study. There was no significant difference between the groups in terms of demographic variables or oral health before the intervention (P > 0.05). The oral health of patients in both the chlorhexidine and liquorice mouthwash groups improved significantly after the intervention (P < 0.05). However, there was no significant difference in oral health between the two groups at postintervention (P = 0.06). Conclusion The results demonstrated that both mouthwashes exerted a comparable effect on dental and oral health. However, the chlorhexidine mouthwash showed a greater impact on the reduction of dental plaque and the thinning of saliva compared to licorice mouthwash. In essential cases, licorice mouthwash can be employed as an alternative to chlorhexidine.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of the effect of licorice and chlorhexidine mouthwash on the oral health of intubated patients in the intensive care unit

Oshvandi,

Lotfi,

Azizi

et al. 2024

BMC Oral Health

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Comparison of the effect of licorice and chlorhexidine mouthwash on the oral health of intubated patients in the intensive care unit

Oshvandi,

Lotfi,

Azizi

et al. 2024

Preprint

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Background Chlorhexidine mouthwash is a common oral hygiene product used in intensive care units, but it may have some adverse effects. Licorice, a natural herb, could be a potential alternative to chlorhexidine. However, the effect of licorice mouthwash on the oral health of intubated patients has not been studied yet. Therefore, this study aimed to compare the effects of licorice and chlorhexidine mouthwash on the oral health of intubated patients. Methods This was a triple-blind clinical trial. The sample included 130 intubated patients admitted to an intensive care unit in Iran. The samples were selected by convenience sampling and randomly assigned to two groups: A and B. In group A, the main researcher applied 15 ml of 0.2% chlorhexidine mouthwash after each brushing (twice a day for 5.5 days) and suctioned it after 30 seconds. In group B, 20% licorice mouthwash was used instead of chlorhexidine. The demographic information questionnaire and the Beck Oral Assessment Scale (BOAS) were completed by one of the nurses before and on the sixth day of the study. Results Finally, 60 patients in each group completed the study. There was no significant difference between the groups in terms of demographic variables or oral health before the intervention (P > 0.05). The oral health of patients in both the chlorhexidine and liquorice mouthwash groups improved significantly after the intervention (P < 0.05). However, there was no significant difference in oral health between the two groups at postintervention (P = 0.06). Conclusion Considering the herbal nature, cost-effectiveness and lack of serious side effects of licorice mouthwash, it can be used as a suitable alternative for chlorhexidine.

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Can Glycyrrhiza glabra L. reduce both upper gastrointestinal tract bleeding and ventilator‐associated pneumonia in intensive‐care unit patients?

Cited by 2 publications

References 16 publications

Comparison of the effect of licorice and chlorhexidine mouthwash on the oral health of intubated patients in the intensive care unit

Comparison of the effect of licorice and chlorhexidine mouthwash on the oral health of intubated patients in the intensive care unit

Comparison of the effect of licorice and chlorhexidine mouthwash on the oral health of intubated patients in the intensive care unit

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