Can High-Sensitivity C-Reactive Protein and Ferritin Predict Functional Outcome in Acute Ischemic Stroke? A Prospective Study

Ozkan, Aslihan

doi:10.1310/tscir2001-528

Cited by 8 publications

(18 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to many authors, the increase in hsCRP levels is associated with poor prognosis, 12 – 14 whereas other researchers suggest that CRP is not a prognostic factor in ischemic stroke. 15 , 16 …”

Section: Introductionmentioning

confidence: 99%

<p>Effect of IL-6 and hsCRP Serum Levels on Functional Prognosis in Stroke Patients Undergoing IV-Thrombolysis: Retrospective Analysis</p>

Pawluk¹,

Grześk²,

Kołodziejska³

et al. 2020

CIA

View full text Add to dashboard Cite

Purpose We evaluated the relationship between pretreatment IL-6 and hsCRP levels, symptom severity and functional outcome of patients with acute ischemic stroke (AIS) treated with IV-thrombolysis. Patients and Methods IL-6 and hsCRP samples were obtained from 83 consecutively treated Caucasian patients with AIS prior to initiation of IV-thrombolysis. Severity of stroke symptoms was assessed using the National Institutes of Health Stroke Scale (NIHSS), whereas functional outcome was assessed with modified Rankin Scale (mRS). The commercially available sets of enzymatic immune tests were used to estimate the concentrations of inflammatory markers in serum. Results Medians of IL-6 serum concentrations prior to IV-thrombolysis were lower in patients with favorable (mRS 0–2 pts) functional outcome than in those with unfavorable (mRS 3–6 pts) functional outcome, both at hospital dismission (5.92: 2.30–7.71 vs 9.46: 3.79–17.29 pg/mL; p <0.01) and on the ninetieth day from stroke onset (5.87: 2.30–10.58 vs 10.9: 5.94–17.28 pg/mL; p <0.01). There were no existing differences regarding hsCRP levels between groups (2.49: 0.11–9.82 vs 4.44: 0.32–9.87 mg/dL; p =0.30 and 2.57: 0.11–2.57 vs 2.83: 0.32–9.32 mg/dL; p =0.75, respectively). Patients with lacunar strokes were characterized by lower median of IL-6 (5.96: 2.87–13.0% vs 7.29: 2.30–17.28; p =<0.02) and hsCRP (2.25: 0.11–9.82 vs 4.84: 0.35–9.87; p =0.01) than those with nonlacunar infarctions. Multivariate analysis showed an impact of IL-6 on mRS measured on hospital dismission and after three months, regardless of their initial NIHSS, presence of hemorrhagic transformation and type 2 diabetes. No impact of hsCRP, lacunar etiology and patients’ age on functional outcome existed. Conclusion Regardless of the stroke etiology, pretreatment of IL-6, but not of hsCRP levels, may help to predict functional outcome after IV-thrombolysis independently of symptom severity and stroke complications.

show abstract

Section: Introductionmentioning

confidence: 99%

<p>Effect of IL-6 and hsCRP Serum Levels on Functional Prognosis in Stroke Patients Undergoing IV-Thrombolysis: Retrospective Analysis</p>

Pawluk¹,

Grześk²,

Kołodziejska³

et al. 2020

CIA

View full text Add to dashboard Cite

show abstract

“…RDW values of ≤12.9 were categorized as normal and ≥ 13.0 were considered as elevated. Stroke severity (NIHSS) was categorized as mild (0-6), moderate (7)(8)(9)(10)(11)(12)(13)(14)(15), and severe . mRS<<2 (0, 1 and 2) was defined as fine outcome.…”

Section: Methodsmentioning

confidence: 99%

“…Regarding the high incidence and mortality rate of ischemic stroke, a predictive parameter related to severity of stroke would enhance the pre-assumption in anti-thrombotic therapeutic approach (7,8).…”

Section: Introductionmentioning

confidence: 99%

The predictive value of red cell distribution width for stroke severity and outcome

Shahsavarinia

Laleh

Moharramzadeh

et al. 2019

Preprint

View full text Add to dashboard Cite

Objectives: In the present study, we sought to investigate the association of RDW with stroke severity and outcomes in patients who underwent anti-thrombolytic administration with tissue plasminogen activator (tPA). Results: This study was conducted during eighteen months at emergency department. During the time of study, 282 subjects were included. The categorization of RDW to <12.9 and >13 values revealed insignificant difference in stroke severity score, accounting for the mean 36-hour NIHSS of 8.19±8.2 in normal RDW values and 9.94±8.28in higher RDW group (p=0.64). In seventh day assessment, NIHSS was 6.46±7.28 in normal RDW group and was 8.52±8.35 in increased RDW group (p=0.058). Neither the thirty-six-hour, nor the seventh day and 3-month MRS demonstrated significant difference between those with normal and higher RDW values.

show abstract

“…A predictive parameter for stroke severity would enhance the antithrombotic therapeutic approach, which may reduce the high incidence and mortality rate of ischemic stroke [5,6]. Red cell distribution width (RDW) is a hematologic parameter that indicates the divergence of red blood cell volume.…”

Section: Introductionmentioning

confidence: 99%

The predictive value of red cell distribution width for stroke severity and outcome

et al. 2020

View full text Add to dashboard Cite

Objectives: In the present study, we sought to investigate the association between red cell distribution width (RDW) and stroke severity and outcome in patients who underwent anti-thrombolytic therapy with tissue plasminogen activator (tPA). Results: In this prospective study, 282 stroke patients who underwent tPA injection were included. The categorization of RDW to < 12.9% and > 13% values revealed insignificant difference in stroke severity score, accounting for the mean 36-h NIHSS of 8.19 ± 8.2 in normal RDW values and 9.94 ± 8.28in higher RDW group (p = 0.64). In seventh day, NIHSS was 6.46 ± 7.28 in normal RDW group and was 8.52 ± 8.35 in increased RDW group (p = 0.058). Neither the 36-h, nor the seventh day and 3-month mRS demonstrated significant difference between those with normal and higher RDW values.

show abstract

Can High-Sensitivity C-Reactive Protein and Ferritin Predict Functional Outcome in Acute Ischemic Stroke? A Prospective Study

Abstract: This study revealed that neither hs-CRP nor ferritin levels could predict functional disability 3 months after stroke onset. FIM, FAS, and NIHSS scores were more useful in predicting functional outcome 3 months after stroke onset than the laboratory markers evaluated in this study.

Cited by 8 publications

References 0 publications

<p>Effect of IL-6 and hsCRP Serum Levels on Functional Prognosis in Stroke Patients Undergoing IV-Thrombolysis: Retrospective Analysis</p>

<p>Effect of IL-6 and hsCRP Serum Levels on Functional Prognosis in Stroke Patients Undergoing IV-Thrombolysis: Retrospective Analysis</p>

The predictive value of red cell distribution width for stroke severity and outcome

The predictive value of red cell distribution width for stroke severity and outcome

Contact Info

Product

Resources

About