Can granulysin provide prognostic value in primary breast cancer?

Milovanović, Jelena; Todorović‐Raković, Nataša; Vujasinović, Tijana; Greenman, John; Mandušić, Vesna; Radulović, Marko

doi:10.1016/j.prp.2022.154039

Cited by 4 publications

(2 citation statements)

References 44 publications

(24 reference statements)

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“…As an immune alarm protein, GNLY plays an important role in antitumor immunity 48 . High levels of GNLY in breast cancer predict the possibility of tumor recurrence and distant metastasis 49 . However, the role of BATF and GNLY in the progression and immunotherapy of endometrial cancer has been less reported.…”

Section: Discussionmentioning

confidence: 99%

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Identification of immunogenic cell death‐associated subtypes and characterization of the tumor microenvironment in endometrial cancer

Pan

Luo

Wang

et al. 2023

The Journal of Gene Medicine

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Immunogenic cell death (ICD) is one of the mechanisms regulating cell death, which activates adaptive immunity in immunocompetent hosts and is associated with tumor progression, prognosis and therapeutic response. Endometrial cancer (EC) is one of the most common malignancies of the female genital tract, and the potential role of immunogenic cell death-related genes (IRGs) in the tumor microenvironment (TME) remains unclear. We describe the variation of IRGs and assess the expression patterns in EC samples from The Cancer Genome Atlas and Gene Expression Omnibus cohorts. Based on the expression of 34 IRGs, we identified two different ICD-related clusters and subsequently differentially expressed genes between the two ICDrelated clusters were used for the identification of two ICD gene clusters. We identified the clusters and found that alterations in the multilayer IRG were associated with patient prognosis and TME cell infiltration characteristics. On this basis, ICD score risk scores were calculated, and ICD signatures were constructed and validated for their predictive power in EC patients. To help clinicians better apply the ICD signature, an accurate nomogram was constructed. The low ICD risk group was characterized by high microsatellite instability, high tumor mutational load, high IPS score and stronger immune activation. Our comprehensive analysis of IRGs in EC patients suggested a potential role in the tumor immune interstitial microenvironment, clinicopathological features and prognosis. These findings may improve our understanding of the role of ICDs, and provide a new basis for assessing prognosis and developing more effective immunotherapeutic strategies in EC.

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Section: Discussionmentioning

confidence: 99%

“…48 High levels of GNLY in breast cancer predict the possibility of tumor recurrence and distant metastasis. 49 However, the role of BATF and GNLY in the progression and immunotherapy of endometrial cancer has been less reported. In this study we further validated the value played efficacy in the treatment of endometrial cancer.…”

Section: Discussionmentioning

confidence: 99%

Identification of immunogenic cell death‐associated subtypes and characterization of the tumor microenvironment in endometrial cancer

Pan

Luo

Wang

et al. 2023

The Journal of Gene Medicine

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Vascular endothelial growth factor (VEGF) -A, -C and VE-cadherin as potential biomarkers in early breast cancer patients

Milovanović,

Vujasinović,

Todorović-Raković

et al. 2023

Pathology - Research and Practice

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Identification of hub modules and therapeutic targets associated with CD8+T-cells in HF and their pan-cancer analysis

Pan,

Zhou,

et al. 2024

Sci Rep

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Heart failure (HF) is a terminal condition of multiple cardiovascular disorders. Cancer is a deadly disease worldwide. The relationship between HF and cancer remains poorly understood. The Gene Expression Omnibus database was used to download the RNA sequencing data of 356 patients with hypertrophic cardiomyopathy-induced HF and non-HF. A co-expression network was established through the weighted correlation network analysis (WGCNA) to identify hub genes of HF and cancer. Cox risk analysis was performed to predict the prognostic risks of HF hub genes in pan-cancer. HF was linked to immune response pathway by the analysis of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). A positive correlation was observed between the expression levels of 4 hub genes and the infiltration of CD8 + T-cells in pan-cancer. 4 hub genes were identified as beneficial prognostic factors in several cancers. Western blotting and real-time polymerase chain reaction validated the high expression of GZMM, NKG7, and ZAP70 in both mice and patients with HF compared to control groups. Our study highlights the shared immune pathogenesis of HF and cancer and provides valuable insights for developing novel therapeutic strategies, offering new opportunities for improving the management and treatment outcomes of both HF and cancer.

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Can granulysin provide prognostic value in primary breast cancer?

Cited by 4 publications

References 44 publications

Identification of immunogenic cell death‐associated subtypes and characterization of the tumor microenvironment in endometrial cancer

Identification of immunogenic cell death‐associated subtypes and characterization of the tumor microenvironment in endometrial cancer

Vascular endothelial growth factor (VEGF) -A, -C and VE-cadherin as potential biomarkers in early breast cancer patients

Identification of hub modules and therapeutic targets associated with CD8+T-cells in HF and their pan-cancer analysis

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